A5032994949- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neuropeptides and Animal Physiology
- Prion Diseases and Protein Misfolding
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Advanced Neuroimaging Techniques and Applications
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Alcoholism and Thiamine Deficiency
- Neurological Disease Mechanisms and Treatments
- Advanced Proteomics Techniques and Applications
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2015-2024
Hospital zum Heiligen Geist
2018-2023
Helios Kliniken
2023
Landscape Research Group
2023
Authorised Association Consortium
2023
Munich Cluster for Systems Neurology
2022
Forschungsinstitut Technologie und Behinderung
2019
Ludwig-Maximilians-Universität München
2018
University of Cologne
2015-2016
Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's disease (AD) and their caretakers. Working long-term declarative are affected early during course disease. The individual pattern impaired functions correlates with parameters structural or functional brain integrity. AD pathology interferes formation memories molecular level to framework neural networks. investigation loss helps identify involved structures, such as default mode network, influence...
Because of its availability, ease collection, and correlation with physiology pathology, urine is an attractive source for clinical proteomics/peptidomics. However, the lack comparable data sets from large cohorts has greatly hindered development proteomics. Here, we report establishment a reproducible, high resolution method peptidome analysis naturally occurring human urinary peptides proteins, ranging 800 to 17,000 Da, using samples 3,600 individuals analyzed by capillary electrophoresis...
<h3>Background</h3> Naltrexone and acamprosate have been shown to be effective in relapse prevention of alcoholism via different pharmacologic mechanisms. Since it remains uncertain whether both substances are equally efficient a combination drugs potentiates the efficacy, we conducted first published controlled study comparing combining compounds. <h3>Methods</h3> After detoxification, 160 patients with participated randomized, double-blind, placebo-controlled protocol. Patients received...
The miRBase-21 database currently lists 1881 microRNA (miRNA) precursors and 2585 unique mature human miRNAs. Since their discovery, miRNAs have proved to present a new level of epigenetic post-transcriptional control protein synthesis. Initial results point possible involvement miRNA in Alzheimer's disease (AD). We applied OpenArray technology profile the expression 1178 cerebrospinal fluid (CSF) samples AD patients (n = 22) controls 28). Using Cq 34 as cut-off, we identified positive...
Neurochemical dementia diagnostics (NDD) can significantly improve the clinically based categorization of patients with early disorders, and cerebrospinal fluid (CSF) concentrations amyloid beta peptides ending at amino acid position 42 (A x-42 A 1-42) are widely accepted biomarkers Alzheimer's disease (AD). However, in subjects constitutively high- or low-CSF total (tA beta), NDD interpretation might lead to erroneous conclusions as these seem correlate better load than pathological status...
<h3>Background</h3> Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according preliminary findings. <h3>Objective</h3> To test whether the addition metyrapone standard antidepressants induces a more rapid, efficacious, and sustained treatment response in patients with major depression. <h3>Design</h3> Double-blind, randomized, placebo-controlled trial. <h3>Setting</h3> Hospitalized care. <h3>Patients</h3> Sixty-three inpatients a<i>DSM-IV</i>diagnosis...
<h3>Objective:</h3> To compare cued recall measures with other memory and nonmemory tests regarding their association a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients mild cognitive impairment (MCI). <h3>Methods:</h3> Data were obtained by the German Dementia Competence Network. A total 185 clinic fulfilling broad criteria for MCI (1 SD deficit or tests) assessed an extended neuropsychological battery, which included Free Cued Selective Reminding Test (FCSRT),...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe but treatable autoimmune affecting mainly young adults and children. The lack of suitable biomarkers disease activity makes treatment decisions identification relapses challenging.To determine the levels B-cell-attracting C-X-C motif chemokine 13 (CXCL13) in serum samples cerebrospinal fluid (CSF) patients with anti-NMDAR whether they can be used as response outcome.Retrospective cohort study 167 consecutively diagnosed...
Background Today, dementias are diagnosed late in the course of disease. Future treatments have to start earlier disease process avoid disability requiring new diagnostic tools. The objective this study is develop a method for differential diagnosis and identification biomarkers Alzheimer's (AD) using capillary-electrophoresis coupled mass-spectrometry (CE-MS) assess potential early AD. Methods Findings Cerebrospinal fluid (CSF) 159 out-patients memory-clinic at University Hospital suffering...
To retrospectively determine the frequency of N-Methyl-D-Aspartate (NMDA) receptor (NMDAR) autoantibodies in patients with different forms dementia.Clinical characterization 660 dementia, neurodegenerative disease without other neurological disorders and age-matched healthy controls combined retrospective analysis serum or cerebrospinal fluid (CSF) for presence NMDAR antibodies. Antibody binding to mutants effect immunotherapy were determined a subgroup patients.Serum antibodies IgM, IgA,...
Objective To investigate the role of neuroinflammation in asymptomatic and symptomatic amyotrophic lateral sclerosis (ALS) frontotemporal dementia (FTD) mutation carriers. Methods The neuroinflammatory markers chitotriosidase 1 (CHIT1), YKL-40 glial fibrillary acidic protein (GFAP) were measured cerebrospinal fluid (CSF) blood samples from ALS/FTD carriers, sporadic cases controls by ELISA. Results CSF levels CHIT1, GFAP unaffected carriers (n=16). CHIT1 increased gALS (p<0.001, n=65)...
Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect underlying disease mechanisms might help in diagnosis, staging and prediction outcome. We aimed at determining the origin differential diagnostic prognostic potential putative marker microglial activation chitotriosidase (CHIT1).Altogether 316 patients were included, comprising with sporadic ALS, ALS mimics (disease controls (DCo)), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jakob (CJD), Alzheimer's (AD),...
<h3>Objective</h3> To determine the association of serum neurofilament light chain (NfL) with functional deterioration and brain atrophy during follow-up patients behavioral variant frontotemporal dementia (bvFTD). <h3>Methods</h3> Blood NfL levels from 74 bvFTD, 26 Alzheimer disease (AD), 17 mild cognitive impairment (MCI), 15 healthy controls (Con) at baseline were determined analyzed for diagnostic potential in relation to assessment (Clinical Dementia Rating Scale Sum Boxes [CDR-SOB],...
Five protein kinases were used to study the phosphorylation pattern of purified skeletal muscle receptor for calcium‐channel blockers (CaCB). cAMP kinase, cGMP kinase C, calmodulin II and casein phosphorylated 165‐kDa 55‐kDa proteins CaCB receptor. The 130/28‐kDa 32‐kDa are not by these kinases. Among only subunit with 2–3‐fold higher initial rate than subunit. Casein comparable rates. C preferentially protein. is 50 times faster or about 10 enzymes kinase. Two‐dimensional peptide maps...
Information on circulating miRNAs in frontotemporal lobar degeneration is very limited and conflicting results have complicated an interpretation Alzheimer's disease thus far. In the present study we I) collected samples from multiple clinical centers across Germany, II) defined 3 homogenous patient groups with high sample sizes (bvFTD n = 48, AD 48 cognitively healthy controls 44), III) compared expression levels both CSF serum IV) detected a set of by using MIQE compliant protocol based...
The progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia can be predicted by cognitive, neuroimaging, and cerebrospinal fluid (CSF) markers. Since most biomarkers reveal complementary information, a combination may increase the predictive power. We investigated which Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR)-sum-of-boxes, word list delayed free recall from Consortium Establish Registry (CERAD) test battery, hippocampal volume (HCV),...
Synaptic degeneration is a major hallmark of Alzheimer's disease (AD) and the best pathological correlate cognitive dysfunction. markers are therefore highly desired read-out for patient diagnosis possible follow-up in clinical trials. Several synaptic AD described cerebrospinal fluid (CSF), but studies blood have failed so far. Using quantitative mass spectrometry (IP-MS, MRM) we observed increased concentrations presynaptic protein beta-synuclein (βSyn) CSF patients (n = 64, p < 0.01)...