A5084665817- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurogenetic and Muscular Disorders Research
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
- Health and Medical Studies
- Cerebral Palsy and Movement Disorders
- Liver Disease and Transplantation
- Action Observation and Synchronization
- Healthcare Decision-Making and Restraints
- Multisensory perception and integration
- Stroke Rehabilitation and Recovery
- Restless Legs Syndrome Research
- Diet and metabolism studies
- S100 Proteins and Annexins
- Text Readability and Simplification
- Cerebrovascular and genetic disorders
- Social Representations and Identity
German Center for Neurodegenerative Diseases
2013-2024
University of Rostock
2014-2024
BG Klinikum Bergmannstrost Halle
2019
Klinik für Psychosomatik
2016
University Medical Center of the Johannes Gutenberg University Mainz
2016
Johannes Gutenberg University Mainz
2016
Trinity College Dublin
2016
Universitätsmedizin Rostock
2015-2016
Max Planck Society
2004
<h3>Objective</h3> To determine the association of serum neurofilament light chain (NfL) with functional deterioration and brain atrophy during follow-up patients behavioral variant frontotemporal dementia (bvFTD). <h3>Methods</h3> Blood NfL levels from 74 bvFTD, 26 Alzheimer disease (AD), 17 mild cognitive impairment (MCI), 15 healthy controls (Con) at baseline were determined analyzed for diagnostic potential in relation to assessment (Clinical Dementia Rating Scale Sum Boxes [CDR-SOB],...
Background: Hippocampal grey matter (GM) atrophy predicts conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Pilot data suggests that mean diffusivity (MD) in the hippocampus, as measured with diffusion tensor imaging (DTI), may be a more accurate predictor of than hippocampus volume. In addition, previous studies suggest volume cholinergic basal forebrain reach diagnostic accuracy superior hippocampal MCI. Objective: The present study investigated whether increased...
Recent work suggests that ALS and frontotemporal dementia can occur together share at least in part the same underlying pathophysiology. However, it is unclear present whether memory deficits stem from a temporal lobe dysfunction, or are rather driven by frontal executive dysfunction. In this study we sought to investigate nature of analyzing neuropsychological performance 40 patients comparison 39 amnestic mild cognitive impairment (aMCI) healthy controls (HC). The battery tested for...
Although a systematic spread of pathologic TDP-43 expression throughout the CNS in amyotrophic lateral sclerosis (ALS) has been proposed, relationship between cognition and extent neuroanatomic distribution pathology not received considerable attention.We investigated association cognitive functioning postmortem tissue from 18 patients with ALS stratified into 3 groups based on detailed prospective neuropsychological testing (cognitively impaired, n = 6; cognitively ALS- frontotemporal...
Frontotemporal dementia (FTD) occurs in two main clinical subtypes, which can transition into one another: the behavioral variant (bvFTD) and language (primary progressive aphasia; PPA). It is common for latter, as primary aphasia (PPA), to bvFTD; however, opposite development, where bvFTD followed by “secondary aphasia,” has received little attention. This constellation particularly challenging recognize frontal dysexecutive syndrome confound subsequent impulsive behavior, a lack of...
Background A relevant fraction of patients with amyotrophic lateral sclerosis (ALS) exhibit a fronto-temporal pattern cognitive and behavioural disturbances pronounced deficits in executive functioning control behaviour. Structural imaging shows decline brain areas, but most studies did not evaluate status. We investigated microstructural white matter changes underlying impairment using diffusion tensor (DTI) large cohort ALS patients. Methods assessed 72 non-demented 65 matched healthy...
Cognitive Rehabilitation for Alzheimer's disease (AD) is an integrative multimodal intervention. It aims to maintain autonomy and quality of life by enhancing the patients' abilities compensate decreased cognitive functioning.We evaluated feasibility a group-based approach in mild AD dementia assessed its effect on activities daily living (ADL).We included 16 patients with controlled partial-randomized design. We adapted manual-guided program (CORDIAL) group setting. Over course three...
<b><i>Background/Aims:</i></b> A substantial proportion of amyotrophic lateral sclerosis (ALS) patients develop cognitive impairments. Longitudinal investigations cognition in ALS have shown mixed results. While some authors report that performance remains stable as the disease progresses, others found evidence for deterioration various domains. Our objective was to investigate longitudinally, using example executive functions....
Pronounced cognitive and behavioural impairments in amyotrophic lateral sclerosis (ALS) concern executive functions behaviour. The valid measurement is challenging as motor disabilities may mask everyday functioning. aim of this study was to determine a detailed characteristic pattern impairment ALS order effectively interpret their clinical impact. We investigated 98 patients without or with frontotemporal dementia (FTD), 70 healthy controls using comprehensive neuropsychological test...
Abstract C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) provided first insights about a prominent involvement thalamus cerebellum. Our multicenter, 18 F-fluorodeoxyglucose positron-emission tomography study 22 mutation carriers with FTLD, matched non-carriers 23 cognitively healthy controls valuable into functional...
To determine whether cognitive reserve (CR) as measured by verbal intelligence quotient, educational length, and achievement protects amyotrophic lateral sclerosis (ALS) patients' fluency, executive functioning, memory against brain volume loss over a period of 12 months.
We investigated whether cognitive reserve measured by education and premorbid IQ allows amyotrophic lateral sclerosis patients to compensate for regional brain volume loss. This was a cross-sectional study. recruited sixty with from two specialist out-patient clinics. All participants underwent neuropsychological assessment; the outcomes were standardized z-scores reflecting verbal fluency, executive functions (shifting, planning, working memory), memory visuo-constructive ability. The...
Background: The "primacy effect," i.e., increased memory recall for the first items of a series compared to following items, is reduced in amnestic mild cognitive impairment (aMCI). Memory task-fMRI studies demonstrated that primacy associated with higher activation hippocampus and temporo-parietal frontal cortical regions healthy subjects. Functional magnetic resonance imaging (fMRI) at resting state revealed functional connectivity (FC) neocortical brain areas, including default mode...
Abstract Objective Half of ALS patients are cognitively and/or behaviourally impaired. As cognition/behaviour and cerebral glucose metabolism can be correlated by means 18 F-Fluorodeoxyglucose positron emission tomography (FDG-PET), we aimed to utilise FDG-PET, first, replicate group-level differences in between non-demented separated into non-impaired (ALSni), impaired (ALSci), (ALSbi), (ALScbi) groups; second, investigate performance various cognitive domains; third, examine the impact...
Abstract Background In this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI). Methods We analyzed fractional anisotropy (FA) mean diffusivity (MD) as indices of WM 70 AD patients (35 carriers, 35 noncarriers) 56 healthy control (HC) subjects (28 28 noncarriers). carriers noncarriers were matched for age gender within each diagnostic group. Results found...
Sleep disturbances and impairment of cognitive function are among the most frequent non-motor symptoms in Parkinson's disease (PD) with negative implications on quality life patients caregivers. Despite fact that sleep a major issue PD patients, only limited data available regarding interactions performance.This post hoc analysis RaSPar trial was therefore designed to further elucidate their impact cognition PD.Twenty-six were evaluated thoroughly including assessments patients' subjective...
Half of all amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD) patients are classified as cognitively impaired, which 10% have frontotemporal dementia (FTD), and an additional 40% suffer from a syndrome not severe enough to be described (cognitively impaired/ALSci). As changes in cerebral function measured by resting-state magnet resonance imaging (rs-fMRI) known ALS, we investigated whether group differences functional connectivity (RSFC) networks could observed...
Delayed recall of the first words a list-the primacy position-is thought to be particularly dependent on intact memory consolidation. Hippocampal volume has been suggested as primary neuronal correlate delayed in cognitively normal elderly individuals. Here, we studied association hippocampal with individuals amnestic mild cognitive impairment (aMCI).We investigated serial position performance 88 subjects aMCI using 16-word list (the California Verbal Learning Test [CVLT]). Primacy and...
Spinal and bulbar muscular atrophy (SBMA), Kennedy's disease, is an adult-onset hereditary neurodegenerative disorder, associated predominantly with a lower motor neuron syndrome eventually endocrine sensory disturbances. In contrast to other diseases such as amyotrophic lateral sclerosis (ALS), the impairment of cognition in SBMA not well documented. We conducted systematic cross-sectional neuropsychological study order investigate patients more thoroughly. investigated 20 genetically...
Background: Cognitive rehabilitation (CR) is a cognitive intervention for patients with Alzheimer's disease (AD) that aims to maintain everyday competences.The analysis of functional connectivity (FC) in resting-state MRI has been used investigate the effects interventions.Objectives: We evaluated effect CR on default mode network FC group mild AD, compared an active control group.Methods: performed three-month interventional study including 16 diagnosis AD.The (IG) consisted eight patients,...
Memory impairment in motor neuron disease (MND) is still an underrecognized feature and has traditionally been attributed to executive dysfunction. Here, we investigate the rate of memory a longitudinal cohort MND patients, its relationship other cognitive functions underlying neuroanatomical correlates. 142 patients with 99 healthy controls (HC) underwent comprehensive neuropsychological testing structural MRI at 3T up four times over period 18 months. Linear-mixed effects models were...