<h3>Background</h3> Naltrexone and acamprosate have been shown to be effective in relapse prevention of alcoholism via different pharmacologic mechanisms. Since it remains uncertain whether both substances are equally efficient a combination drugs potentiates the efficacy, we conducted first published controlled study comparing combining compounds. <h3>Methods</h3> After detoxification, 160 patients with participated randomized, double-blind, placebo-controlled protocol. Patients received...

Patient adherence is necessary for successful medication therapy. However, highly complex regimens may lead to poor adherence, which decreases the effectiveness of treatment and often results in failure, excessive morbidity mortality, higher costs. To examine whether patient can be increased indirectly through reducing complexity by (a) pharmaceutical counseling hospital medical staff (b) additional information discharge letter primary care provider (PCP) about simplified medication. At...

Several classifications to identify and avoid use of potentially inappropriate medications (PIMs) in the elderly have been published. To what extent these match each other whether there are differences prevalence PIM at admission, during inpatient stay discharge largely unreported.To determine patients a university hospital, with special focus on different classification systems chronological sequence, examine possible association between reason for as well severe side effects consequences...

Routine clinical TDM data is often used to develop population pharmacokinetic (PK) models, which are applied in turn for model-informed precision dosing. The impact of uncertainty documented sampling and infusion times PK modeling dosing have not yet been systematically evaluated. aim this study was investigate uncertain documentation (i) (ii) rate exemplified with two anti-infectives.A stochastic simulation estimation performed NONMEM® using previously published models meropenem...

Several factors contribute to the complexity of pharmacotherapeutic regimens, like total number medications be taken, dosage units take at a time, frequency, as well specific directions concerning administration. The Medication Regimen Complexity Index (MRCI) is validated instrument developed in English for measurement given regimen.Translation MRCI into German and evaluation translated (MRCI-D) order make it more easily accessible use practice research.The process validation included...

The aim of the study was to describe population pharmacokinetics (PK) meropenem in critically ill patients receiving sustained low-efficiency dialysis (SLED). Prospective PK on 19 septic treated with and SLED for acute kidney injury. Serial blood samples determination concentrations were taken before, during after up three sessions per patient. Nonparametric analysis Monte Carlo simulations used. Pharmacodynamic (PD) targets 40% 100% time above minimal inhibitory concentration (f T > MIC)...

Pharmacists are essential team members in critical care and contribute to the safety of pharmacotherapy for this vulnerable group patients, but little is known about remote pharmacy services intensive units (ICU).

Single elements of the Closed Loop Medication Management process (CLMM), including electronic prescribing, involvement clinical pharmacists (CPs), patient individual logistics and digital administration/documentation, have shown to improve medication safety health outcomes. The impact complete CLMM on safety, as reflected in pharmacists' interventions (PIs), is largely unknown.

3D printing offers the possibility to prepare personalized tablets on demand, making it an intriguing technology for hospital pharmacies. For implementation of 3D-printed into digital Closed Loop Medication Management system, required tablet formulation and development manufacturing process as well pharmaceutical validation were conducted. The goal was enable optimal rapid dissolution printed selected model drugs Levodopa ⁄ Carbidopa. prepared by direct powder extrusion. Printability,...

To describe the population PKs of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis (SLED).This study was performed ICUs a university hospital. We collected blood samples during three consecutive days SLED sessions ceftazidime. Concentration versus time curves were analysed using approach with Pmetrics ® . Monte Carlo simulation for first 24 h including 6 session final model. The fractional target attainment against MIC Pseudomonas aeruginosa executed targets...

Intracerebroventricular enzyme replacement therapy (ICV-ERT) for CLN2 disease represents the first approved treatment neuronal ceroid lipofuscinosis (NCL) diseases. It is where a recombinant lysosomal enzyme, cerliponase alfa, administered into lateral cerebral ventricles to reach central nervous system, organ affected in disease. If untreated, children show symptoms such as epilepsy and language developmental delay at 2-4 years followed by rapid loss of motor function, vision loss, early...

Extracorporeal membrane oxygenation (ECMO) is utilized to temporarily sustain respiratory and/or cardiac function in critically ill patients. Ciprofloxacin used treat nosocomial infections, but data describing the effect of ECMO on its pharmacokinetics lacking. Therefore, a prospective, observational trial including adults (n = 17), treated with ciprofloxacin (400 mg 8-12 hourly) during ECMO, was performed. Serial blood samples were collected determine concentrations assess their...

Inappropriate use of broad-spectrum antimicrobials affects adversely both the individual patient and general public. The aim study was to identify patients at risk for excessively prolonged carbapenem treatment in ICU as a target antimicrobial stewardship interventions.Case-control network 11 ICUs university hospital. Patients with uninterrupted meropenem therapy (MT) > 4 weeks were compared controls. Controls defined who stayed on received ≤ 2 weeks. Associations between case-control status...

3D-printing of medicines is an innovative manufacturing method that characterised by a high degree digitalisation and automation enables patient-specific care. Its integration into routine healthcare processes currently fails mainly due to the requirements digital environment. Our hospital was first in Europe introduce fully comprehensive patient record 2011 digitalise automate drug supply process. The aim our study evaluate machine-learning assisted 3D printing already existing, medication...

After knee replacement, therapy resistant, chronic synovitis is common and leads to effusion pain. A cohort of 55 patients with 57 replacements underwent radiosynoviorthesis. In summary, 101 joints were treated using 182±9 MBq 90Y-citrate. The number radiosynoviorthesis ranged from 1 4 (53%, 21%, 23%, 4%). Every patient received a 99mTc-MDP scintigraphy before three months after every Follow-up 5.7 86.7 months. For qualitative analysis, an four steps scoring was used (0 = no response or...

Abstract Purpose Bacterial pneumonia, a major cause of respiratory tract infections (RTI), can be challenging to diagnose and treat adequately, especially when seasonal viral pathogens co-circulate. The aim this study was give real-world snapshot the burden disease treatment choices in emergency department (ED) tertiary care hospital Germany fall 2022. Methods Anonymized analysis quality control initiative that prospectively documented all patients presenting our ED with symptoms suggestive...

The diagnosis and treatment of Parkinson's disease depend on the assessment motor symptoms. Wearables machine learning algorithms have emerged to collect large amounts data potentially support clinicians in clinical ambulant settings.However, a systematical reusable architecture for storage, processing, analysis inertial sensor is not available. Consequently, datasets vary significantly between studies prevent comparability.To simplify research neurodegenerative disorder, we propose an...

Abstract Purpose Digital closed-loop medication administration (CLMA) is a prime example of how digitalization in healthcare can reduce time and costs while simultaneously increasing patient safety. However, contrast to its social economic benefits, associated environmental impacts have never been investigated. Since the required amount packaging material seen as major subject criticism, we assess burdens using life cycle assessment (LCA) methodology identify hotspots provide adaptation...

<h3>Background</h3> Medicines errors are common, costly, and responsible for clinically important problems. The main error-prone process steps prescription, transcription, dispensing administration. Different strategies to prevent medicines like implementation of computerised physician order entry (CPOE), pharmacy validation, unit-dose supply, barcoding at point care discussed. With a combination different closed loop administration can be achieved, which should most efficient errors....