A5017065613- Skin Protection and Aging
- Metabolism and Genetic Disorders
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Dermatological and Skeletal Disorders
- melanin and skin pigmentation
- Cutaneous Melanoma Detection and Management
- Cardiac Arrhythmias and Treatments
- Immunodeficiency and Autoimmune Disorders
- Congenital Heart Disease Studies
- Connective tissue disorders research
- Genetic Neurodegenerative Diseases
- Chronic Lymphocytic Leukemia Research
- Genetic and rare skin diseases.
- Liver Disease Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Photodynamic Therapy Research Studies
- Psoriasis: Treatment and Pathogenesis
- RNA regulation and disease
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Corneal surgery and disorders
- Blood disorders and treatments
University Hospital Regensburg
2015-2024
University of Regensburg
2014-2024
Universitätsmedizin Greifswald
2023
University of Tübingen
2005-2021
University of Michigan
2019
Kaiser-Franz-Josef-Spital
2014-2015
Klinik und Poliklinik für Neurologie
2014-2015
Hautklinik Heidelberg
2004-2012
University Hospital Münster
2009
Medical University of Vienna
2009
Mutations of mitochondrial (mt) DNA accumulate during normal aging. The most frequent mutation is a 4,977-base pair deletion also called the common deletion, which increased in photoaged skin. Oxidative stress may play major role generation large scale mtDNA deletions, but direct proof for this has been elusive. We therefore assessed whether can be generated <i>in vitro</i> through UV irradiation and reactive oxygen species are involved process. Normal human fibroblasts were repetitively...
It has been generally believed that the four main causes of melasma are pregnancy, hormonal contraception, family history and sun exposure; however, there few published comprehensive studies confirm these assertions. The Pigmentary Disorders Academy - an international group experts in pigmentary disorders designed conducted a global survey women to investigate effect factors on onset chronicity course disease order gain better understanding causative associated with this disorder, particular...
Phototherapy of skin diseases such as psoriasis is an effective and safe treatment modality. However, increasing the risk cancer by phototherapy a serious concern. An increased occurs after prolonged photochemotherapy (PUVA). In contrast, role broadband UVB or narrowband therapy in carcinogenesis humans with less clear. Therefore, we investigated incidence tumours total 195 patients, receiving (n=69) (n=126) from 1994 to 2000 follow-up until 2003. Data were raised regional interdisciplinary...
Granulomatous cutaneous T-cell lymphomas (CTCLs) are rare and represent a diagnostic challenge. Only limited data on the clinicopathological prognostic features of granulomatous CTCLs available. We studied 19 patients with to further characterize clinicopathological, therapeutic, features.The group included 15 mycosis fungoides (GMF) 4 slack skin (GSS) defined according World Health Organization-European Organization for Research Treatment Cancer classification lymphomas. Patients GMF GSS...
Defects in the DNA repair mechanism nucleotide excision (NER) may lead to tumors xeroderma pigmentosum (XP) or premature aging with loss of subcutaneous fat Cockayne syndrome (CS). Mutations mitochondrial (mt)DNA play a role aging, but link between NER-associated CS proteins and base (BER)-associated remains enigmatic. We show functional increase CSA CSB inside mt complex formation mtDNA, human 8-oxoguanine glycosylase (mtOGG)-1, single-stranded binding protein (mtSSBP)-1 upon oxidative...
Wound repair is a quiescent mechanism to restore barriers in multicellular organisms upon injury. In chronic wounds, however, this program prematurely stalls. It known that patterns of extracellular signals within the wound fluid are crucial healing. Extracellular pH (pHe) precisely regulated and potentially important signaling wounds due its diverse cellular effects. Additionally, sufficient oxygenation prerequisite for cell proliferation protein synthesis during tissue repair. was,...
A COVID-19 vaccine can be an important key for mitigating the spread of pandemic, provided that it is accepted by a sufficient proportion population. This study investigated parents' intention to get vaccinated and have one's child against COVID-19. In May 2020, 612 parents participating with their in KUNO-Kids health completed online survey. Multivariable logistic regression models were calculated analyze predictors vaccinate. Fifty-eight percent intended COVID-19, 51% vaccinated....
The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria’s involvement in many mechanisms identified depression the high prevalence of MDD individuals with mitochondrial disorders. Mitochondrial functions energy metabolism are considered to be involved MDD’s pathogenesis. This study focused on cellular (dys)function two atypical cases: an antidepressant non-responding patient (“Non-R”) another unexplained (“Mito”). Skin...
Abstract Normal ageing processes are associated with an accumulation of mutations within the mitochondrial (mt) DNA. The most frequent mutation is a 4977 base pair (bp) deletion known as common deletion. In order to test hypothesis that chronically sun‐exposed skin characterized by increased frequency mtDNA, between and another replicating tissue (the hematopoietic system) versus sun‐protected was compared in same individuals. This done comparing amount mutated mtDNA molecules whole genome...
Summary The free radical theory of aging postulates that the production mitochondrial reactive oxygen species is major determinant and lifespan. Its role in connective tissue has not yet been established, even though incidence aging‐related disorders tissue‐rich organs high, causing disability elderly. We have now addressed this question experimentally by creating mice with conditional deficiency manganese superoxide dismutase fibroblasts other mesenchyme‐derived cells tissues all organs....
Azathioprine is associated with enhanced skin photosensitivity to ultraviolet A (UVA) and leads incorporation of 6-thioguanine (6-TG) into DNA dividing cells. Unlike canonical DNA, 6-TG damaged by UVA, which comprises more than 90% the reaching earth. Skin UVA UVB was measured in 48 kidney transplant patients immunosuppressed either azathioprine (n = 32) or mycophenolate 16). In 23 patients, subsequently replaced photosensitivity, content peripheral blood mononuclear cells, susceptibility...
// Andreas Koch 1 , Sven Arke Lang 2 Peter Johannes Wild 3 Susanne Gantner 4 Abdo Mahli Gerrit Spanier 5 Mark Berneburg Martina Müller Anja Katrin Bosserhoff 6 and Claus Hellerbrand Department of Internal Medicine I, University Hospital Regensburg, Germany Surgery, Institute Pathology, Zurich, Switzerland Dermatology, Cranio-Maxillo-Facial Biochemistry, Erlangen, Correspondence to: Hellerbrand, email: Keywords : GLUT1, melanoma, metastasis, glycolysis, JNK Received April 30, 2015 Accepted...