A5048512557- Skin Protection and Aging
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Toxic Organic Pollutants Impact
- Pancreatic function and diabetes
- RNA regulation and disease
- Cancer-related Molecular Pathways
- T-cell and B-cell Immunology
- Telomeres, Telomerase, and Senescence
- Fibroblast Growth Factor Research
- Immunotoxicology and immune responses
- Proteoglycans and glycosaminoglycans research
- Tryptophan and brain disorders
- Carcinogens and Genotoxicity Assessment
- Genetic Neurodegenerative Diseases
- Microbial metabolism and enzyme function
- Retinoids in leukemia and cellular processes
- Redox biology and oxidative stress
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- Histone Deacetylase Inhibitors Research
Leibniz Institute of Environmental Medicine
2010-2024
Heinrich Heine University Düsseldorf
2004-2011
Defects in the DNA repair mechanism nucleotide excision (NER) may lead to tumors xeroderma pigmentosum (XP) or premature aging with loss of subcutaneous fat Cockayne syndrome (CS). Mutations mitochondrial (mt)DNA play a role aging, but link between NER-associated CS proteins and base (BER)-associated remains enigmatic. We show functional increase CSA CSB inside mt complex formation mtDNA, human 8-oxoguanine glycosylase (mtOGG)-1, single-stranded binding protein (mtSSBP)-1 upon oxidative...
The HDAC inhibitor SAHA rescues the skin phenotype in CSB-deficient mice by enhancing protein acetylation and inducing autophagy.
Defects in the DNA repair mechanism nucleotide excision (NER) may lead to tumors xeroderma pigmentosum (XP) or premature aging with loss of subcutaneous fat Cockayne syndrome (CS). Mutations mitochondrial (mt)DNA play a role aging, but link between NER-associated CS proteins and base (BER)-associated remains enigmatic. We show functional increase CSA CSB inside mt complex formation mtDNA, human 8-oxoguanine glycosylase (mtOGG)-1, single-stranded binding protein (mtSSBP)-1 upon oxidative...
The ligand-activated aryl hydrocarbon receptor (AHR) is known to modulate many genes in a highly cell-specific manner, either directly or indirectly via secondary effects. In contrast, little about the effects of AHR deficiency on gene expression balance. We compared transcriptome CD4 T cells from AHR-/- mice and wild-type mice; 390 genes, them immunotypic, were deregulated AHR-deficient cells. TCDD-induced changes correlated with level immune However, there was overlap AHR-dependent...
The antipsychotic drug clozapine demonstrates superior efficacy in treatment-resistant schizophrenia, but its intracellular mode of action is not completely understood. Here, we analysed the effects (2.5–20 µM) on metabolic fluxes, cell respiration, and ATP human HL60 cells. Some results were confirmed leukocytes clozapine-treated patients. Neuroreceptor inhibition under reduced Akt activation with decreased glucose uptake, thereby inducing ER stress unfolded protein response (UPR)....
Deletions within the mitochondrial DNA (mtDNA) are thought to contribute extrinsic skin aging. To study translation of mtDNA deletions into functional and structural changes in skin, we seeded human fibroblasts collagen gels generate dermal equivalents. These cells were either derived from Kearns-Sayre syndrome (KSS) patients, who constitutively carry large amounts UV-inducible common deletion, or normal volunteers. We found that KSS fibroblasts, comparison with contracted faster more...
Aged tissues contain increased levels of large-scale deletions the mitochondrial (mt) DNA. Especially extrinsically aged skin has been shown to carry a significant burden mtDNA along with several other structural and functional impairments. Until now role mutations for changes is not understood. Therefore we studied how human cells harbouring affect their microenvironment by comparing normal fibroblasts (NHF) dermal derived from patients suffering Kearns-Sayre syndrome (KSS) in 3D...