A5045117927- Skin Protection and Aging
- Cardiomyopathy and Myosin Studies
- melanin and skin pigmentation
- Muscle Physiology and Disorders
- Antioxidant Activity and Oxidative Stress
- Dermatology and Skin Diseases
- Bee Products Chemical Analysis
- Allergic Rhinitis and Sensitization
- RNA Research and Splicing
- Indoor Air Quality and Microbial Exposure
- Wound Healing and Treatments
- Pluripotent Stem Cells Research
- Nuclear Structure and Function
- Dermatologic Treatments and Research
- RNA Interference and Gene Delivery
- Biochemical Analysis and Sensing Techniques
- Advancements in Transdermal Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Genomics and Chromatin Dynamics
- Hair Growth and Disorders
- Proteoglycans and glycosaminoglycans research
- Mesenchymal stem cell research
- Effects of Radiation Exposure
- Retinoids in leukemia and cellular processes
- Tissue Engineering and Regenerative Medicine
Leibniz Institute of Environmental Medicine
2014-2024
Heinrich Heine University Düsseldorf
2020
Centers for Disease Control and Prevention
2014
Royal Veterinary College
1991-1992
University College London
1991-1992
University of London
1991-1992
Max Planck Institute for Medical Research
1989-1990
Max Planck Society
1990
Striated muscle is a tissue in which gene expression influenced to large extent by mechanical signals. This includes the regulation of expression-associated fiber phenotype determination, depends on protein isoform genes are transcribed, as well mass accretion, appears involve some translational regulation. Although synthesizes set highly specialized proteins it has remarkable ability adapt expressing different isoforms same so that acquires appropriate contractile characteristics. Our work...
Increasing evidence suggests photoprotection by oral supplementation with β‐carotene and lycopene. To examine the capacity of lycopene‐rich tomato nutrient complex (TNC) lutein, to protect against ultraviolet (UV)A/B UVA1 radiation at a molecular level. In placebo‐controlled, double‐blinded, randomized, crossover study two active treatments containing either TNC or lutein were assessed for their decrease expression radiation‐inducible genes HO1, ICAM1 MMP1. Sixty‐five healthy volunteers...
Infrared A radiation (IRA) from solar sunlight contributes to photoaging of human skin, e.g. by upregulating MMP-1 expression in dermal fibroblasts, indicating the need for photoprotection skin against IRA. Up now, however, there has been no controlled study show that effective protection IRA is possible. Here, we have conducted a randomized, controlled, double-blinded prospective 30 healthy volunteers assess capacity an SPF sunscreen versus same supplemented with antioxidant cocktail...
Conference Article| April 01 1991 Stretch and force generation induce rapid hypertrophy myosin isoform gene switching in adult skeletal muscle Geoffrey Goldspink; Goldspink 1Unit of Molecular Cellular Biology, The Royal Veterinary College, London University, College Street, NW1 0TU, U.K. Search for other works by this author on: This Site PubMed Google Scholar Andrew Scutt; Scutt Jane Martindale; Martindale Thomas Jaenicke; Jaenicke Lucien Turay; Turay Gerald-F. Gerlach Biochem Soc Trans...
In recent years there has been an increasing interest in the use of nutritional supplements to benefit human skin. Molecular evidence substantiating such effects, however, is scarce. present study we investigated whether supplementation women with standardized pine bark extract Pycnogenol® will improve their cosmetic appearance and relate these effects expression corresponding molecular markers skin.For this purpose 20 healthy postmenopausal were supplemented Pycnogenol for 12 weeks. Before,...
Melanism is more frequent in animals living polluted areas on urban-industrial sites. Given that an increasing number of people are exposed to elevated air pollution levels, it possible environmental pollutants affect melanogenesis human skin. Epidemiological studies have shown exposure traffic-related such as diesel exhaust particles (DEP) associated with clinical signs hyperpigmentation. However, mechanistic evidence linking DEP pigmentation has been elusive.To develop ex␣vivo skin model...
Moderate to severe AD can be successfully managed by systemic treatments. Current guidelines also recommend emollients or 'plus' and eudermic cleansers for all patients improve the skin barrier provide anti-irritant anti-pruritic effects.To investigate efficacy of care (in addition treatment) with an Emollient balm designed microbiome plus a corresponding syndet compared usual commercial cleansers.In randomized controlled multicenter study, moderate (Severity scoring atopic dermatitis...
Abstract: The efficacy of sunscreens to protect against ultraviolet (UV) A radiation is usually assessed by measuring erythema formation and pigmentation. biological relevance these endpoints for UVA-induced skin damage, however, not known. We therefore carried out two complementary studies determine UVA protection provided a broad-spectrum sunscreen product at molecular level studying radiation-induced gene expression. One study was performed on human reconstructed in vitro with semi-global...
Polymorphic light eruption (PLE) is the most common photodermatosis. Little known about efficacy of systemic photoprotection provided by nutritional supplements in PLE patients.The purpose this study was to assess supplement containing lycopene, β-carotene, and Lactobacillus johnsonii diminish skin lesions induced 'photoprovocation' testing patients.In randomized, placebo-controlled, double-blinded study, 60 patients were supplemented with or placebo. For inducing lesions, patient exposed...
<b><i>Background:</i></b> Our previous double-blinded, placebo-controlled cross-over study indicated that a nutritional supplement named lycopene-rich tomato nutrient complex (TNC) can protect from UVA1-induced (340–400 nm) and UVA- (320–400 nm)/UVB-induced (280–320 upregulation of molecular markers associated with oxidative stress, inflammation, ageing. <b><i>Objectives:</i></b> in the current double-blind, randomized, multicenter study, we...
Photoprotection of human skin is determined as the capacity sunscreens to prevent ultraviolet (UV) B radiation-induced erythema and UVA pigmentation. It unequivocal that, in addition sunscreens, oral supplementation with carotenoids can protect against UVB erythema. not known if this also case for pigmentation.To clinically evaluate photoprotective effects daily pigmentation.In double-blind, placebo-controlled trial, 60 subjects (Fitzpatrick types II-IV) were randomized receive Nutrilite™...
Abstract: Uneven skin pigmentation is a significant cosmetic concern, and the identification of topically applicable molecules to address this issue general interest. We report that tetrapeptide PKEK (Pro‐Lys‐Glu‐Lys) can exert whitening effects based on one in vitro four double‐blinded vehicle‐controlled vivo studies. (i) Treatment human keratinocytes with significantly reduced UVB‐stimulated mRNA expression interleukin (IL)‐6, IL‐8 TNF‐α and, most importantly, proopiomelanocorticotropin...
According to National HIV Behavioral Surveillance system data, human immunodeficiency virus (HIV) testing increased among gay, bisexual, and other men who have sex with from 2008 2011 in cities funded by the Centers for Disease Control Prevention's Expanded Testing Initiative, suggesting that focused initiatives might positive effects.
<b><i>Introduction:</i></b> Skin ageing involves senescent fibroblast accumulation, disturbance in extracellular matrix (ECM) homeostasis, and decreased collagen synthesis. <b><i>Objective:</i></b> to assess a cell therapy product for aged skin (RCS-01; verum) consisting of ~25 × 10<sup>6</sup> cultured, autologous cells derived from anagen hair follicle non-bulbar dermal sheath (NBDS). <b><i>Methods:</i></b>...
<b><i>Introduction:</i></b> Bathing in the Blue Lagoon (BL) Iceland benefits patients with psoriasis. Accordingly, BL water contains algae biological activities that improve skin barrier function and affect T-cell responses relevant for is also becoming increasingly popular among healthy individuals anecdotal evidence suggests positive effects on uneven pigmentation. <b><i>Objective:</i></b> The aim of study was to address impact...