A5063143071- Bone health and treatments
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Pancreatic function and diabetes
- Schizophrenia research and treatment
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Bone Metabolism and Diseases
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Bone fractures and treatments
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Mass Spectrometry Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Cultural Heritage Materials Analysis
- Metabolism, Diabetes, and Cancer
- Hemoglobinopathies and Related Disorders
- Bone health and osteoporosis research
- Endoplasmic Reticulum Stress and Disease
Heinrich Heine University Düsseldorf
2006-2024
Hôpital Broussais
1977
The aim of our study was to investigate the impact typical and atypical antipsychotic drugs on leptin concentration in blood changes receptor expression hypothalamus male Wistar rats.From age 13 18 weeks, three groups 20 animals were fed an average dose 3.5 + 0.03 mg/ kg body weight (BW) haloperidol; 30.6 0.22 mg/kg BW clozapine; or 14.9 0.13 ziprasidone ground food pellets containing 15% fat. Twenty control received no drugs. Blood samples taken at week 14, 16, 19. Locomotor activity...
An increased risk for metabolic syndrome has been described patients with psychotic disorders. Antipsychotic drugs possibly contribute to changes.Haloperidol or clozapine was orally fed male and female Sprague Dawley rats 12 weeks, body weight gain, food water intake were measured. The serum levels of fasting glucose, HbA1c, triglycerides, cholesterol, HDL LDL, insulin, leptin, adiponectin ghrelin determined. Gonadal perirenal fat pads removed weighed.We found in the group, but decreased...
Abstract Objective Sex‐dependent disturbances of peripheral glucose metabolism are known complications antipsychotic drug treatment. The influence long‐term clozapine and haloperidol medication on hypothalamus, maintaining aspects internal body homeostasis, has not yet been completely clarified. Methods After puberty, male female Sprague Dawley rats were fed orally with ground pellets containing (1 mg/kgBW/day) or (20 for 12 weeks. hypothalamic protein expression dopamine receptors D2R D4R,...
Abstract Background Patients with liver diseases often have some form of anemia. Hematological dyscrasias are known side effects antipsychotic drug medication and the occurrence agranulocytosis under clozapine is well described. However, sex-dependent impact haloperidol on erythrocytes symptoms like anemia, its association hepatic iron metabolism has not yet been completely clarified. Therefore, in present study, we investigated effect both drugs blood parameters male female Sprague Dawley...
Antipsychotic drug (APD) medication can lead to metabolic dysfunctions and weight gain, which together increase morbidity mortality. Metabolically active visceral adipose tissue (VAT) in particular plays a crucial role the etiopathology of these dysregulations. Here we studied effect 12 weeks by daily oral feeding clozapine haloperidol on perirenal fat as part VAT male female Sprague Dawley rats context complex former investigations brain, liver, blood. Adipocyte area values were determined...
Antipsychotic drug (APD) medication can lead to metabolic dysfunctions and weight gain, which together increase morbidity mortality. Metabolically active visceral adipose tissue (VAT) in particular plays a crucial role the etiopathology of these dysregulations. Here, we studied effect 12 weeks by daily oral feeding clozapine haloperidol on perirenal fat as part VAT male female Sprague Dawley rats context complex former investigations brain, liver, blood. Adipocyte area values were...
The antipsychotic drug clozapine demonstrates superior efficacy in treatment-resistant schizophrenia, but its intracellular mode of action is not completely understood. Here, we analysed the effects (2.5–20 µM) on metabolic fluxes, cell respiration, and ATP human HL60 cells. Some results were confirmed leukocytes clozapine-treated patients. Neuroreceptor inhibition under reduced Akt activation with decreased glucose uptake, thereby inducing ER stress unfolded protein response (UPR)....
Although schizophrenia affects both human genders, there are gender-dependent differences with respect to age of onset, clinical characteristics, course and prognosis the disease.To investigate sex-dependent in motor coordination activity as well cognitive social behavior, we repeatedly tested female (n = 14) male 12) Fisher rats (postnatal days, PD 56-174) that had received intracerebroventricular injections kainic acid 15) 16) control animals. The hippocampus was examined...
Antipsychotic drugs are known to have sex-dependent effects on metabolic homeostasis. Liver plays a crucial role in drug degradation as well glucose and lipid metabolism. The present study examines the influence of clozapine haloperidol liver parameters. Over 12 weeks, male female Sprague-Dawley rats were fed ground pellets containing or haloperidol. mass was weighed index calculated. transaminases (ALAT, ALP), malondialdehyde, glucose, triglycerides, total cholesterol, HDL-cholesterol,...