A5087113416- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Urological Disorders and Treatments
- Esophageal and GI Pathology
- Pancreatic function and diabetes
- Neonatal Respiratory Health Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Heart Disease Studies
- Genetic and Kidney Cyst Diseases
- Virus-based gene therapy research
- Appendicitis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Trauma Management and Diagnosis
- Abdominal Trauma and Injuries
- Herpesvirus Infections and Treatments
- Gastrointestinal disorders and treatments
- Renal and related cancers
University Hospital of Geneva
2016-2025
University of Geneva
2015-2025
Swiss Finance Institute
2022-2024
Geneva College
2011-2024
ERN RARE-LIVER
2023
Alder Hey Children's NHS Foundation Trust
2021
Hôpital Beau-Séjour
2008-2020
HES-SO University of Applied Sciences and Arts Western Switzerland
2019
University of Lausanne
2017
Pediatric Oncology Group
2017
Increased age at surgery has a negative impact on results of the Kasai operation for biliary atresia in infancy and early childhood. It remained unclear if an threshold exists this effect persists with extended follow-up. In study we examined relationship between increased its adolescence.All patients who were living France born 1986 2002 included. Median follow-up survivors was 7 years.Included 743 atresia, 695 whom underwent operation; 2-, 5-, 10-, 15-year survival rates native liver...
In Brief Background: The surgical management of Hirschsprung's disease (HD) has evolved from the original 3-stage approach to recent introduction minimal-access single-stage techniques. We reviewed early results transanal Soave pullthrough 6 centers use it. Methods: clinical course all children with HD undergoing a 1-stage between 1995 and 2002 were reviewed. Children preliminary stoma or total colonic excluded. Results: There 141 patients. Mean time diagnosis surgery was 32 days, mean age...
To determine the epidemiology of biliary atresia (BA) in Switzerland, outcome children from diagnosis, and prognostic factors.The records all patients with BA born Switzerland between January 1994 December 2004 were analyzed. Survival rates calculated Kaplan-Meier method, factors evaluated log rank test. Median follow up was 58 months (range, 5-124).BA diagnosed 48 children. Incidence 1 17,800 live births (95% confidence interval 1/13,900-1/24,800), without significant regional, annual, or...
Biliary atresia is a rare neonatal disease of unknown etiology, where obstruction the biliary tree causes severe cholestasis, leading to cirrhosis and death in first years life, if condition left untreated. most frequent surgical cause cholestatic jaundice neonates should be evoked whenever this clinical sign associated with pale stools hepatomegaly. The treatment currently recommended as sequence of, eventually, two interventions. During months life hepatoportoenterostomy (a “Kasai,”...
Varicella can have a severe course in immunosuppressed patients. Although prevention is fundamental, live-attenuated varicella-zoster (VZV) vaccine not currently recommended transplant recipients. Our aims were to (1) evaluate VZV immunity pediatric liver (LT) recipients; (2) immunize (two doses) seronegative patients post-LT; (3) monitor safety, (4) assess B and T cell responses. All followed at the Swiss National Pediatric LT Center approached 77/79 (97.5%) enrolled (median age 7.8 years)....
Endogenous retroelements (EREs) account for about half of the mouse or human genome, and their potential as insertional mutagens transcriptional perturbators is suppressed by early embryonic epigenetic silencing. Here, we asked how ERE control maintained during generation induced pluripotent stem cells (iPSCs), this procedure involves profound remodeling. We found that all EREs tested were markedly up-regulated reprogramming either fibroblasts, CD34 + cells, primary hepatocytes. At iPSC...
Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized treated early in life. It the most common cause of liver-related death children leading indication for transplantation pediatric population. Timely intervention Kasai portoenterostomy (KPE) can significantly improve prognosis. Delayed recognition, late patient referral, untimely surgery remains worldwide problem. This article will focus on biliary from global public...
Abstract Keratinocyte growth factor (KGF) promotes intestinal epithelial growth. To understand the relevance of intraepithelial lymphocyte (IEL)-derived KGF expression on growth, we used a mouse model villus atrophy by administration total parenteral nutrition, and hypertrophy creation short bowel syndrome. was confined to γδ-ΤCR+ IELs. IEL-derived highest in crypts, somewhat less lower portion villi, markedly upper villi. Total nutrition associated with down-regulation expression, syndrome...
Live-attenuated vaccines are currently contraindicated in solid-organ transplant recipients. However, the risk of vaccine-preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver recipients with measles IgG antibodies <150 IU/L (below seroprotection threshold) received measles-mumps-rubella vaccine (MMR) at a median 6.3 years posttransplantation (interquartile range, 4.0 to 10.9). A...
(1) Background: Acute cholangitis during the first year after Kasai hepatoportoenterostomy (HPE) has a negative impact on patient and native liver survival. There are no consistent guidelines for definition, treatment, prophylaxis of HPE. The aim this study was to develop allow expeditious management standardization in reporting. (2) Methods: Delphi method, an extensive literature review, iterative rounds surveys, expert panel discussions were used establish (3) Results: Eight elements...
Congenital portosystemic shunts are often associated with systemic complications, the most challenging of which liver nodules, pulmonary hypertension, endocrine abnormalities, and neurocognitive dysfunction. In present paper, we offer expert clinical guidance on management make recommendations regarding shunt closure follow-up.
The liver is a super organ that does hundreds of important jobs. It cleans your blood, makes critical proteins, and produces liquid called bile, which helps digest the food you eat. In some children, can get very sick because they are born with blockage in tubes carry bile to intestine, causes build up damage it. When cannot do its job properly, must be replaced through major operation transplant. For small piece an adult often enough. After surgery, patients need medication help them adjust...
ABSTRACT Background Post‐transplant lymphoproliferative disorders (PTLD) may significantly impair outcomes in children after solid organ transplantation (SOT). Diagnosis and treatment be challenging. We analyze a representative pediatric liver transplant (LT) cohort light of these challenges. Methods Pediatric LT recipients monitored by the Swiss Liver Center from 2009 to 2021 with suspicion Epstein–Barr virus (EBV) driven PTLD were included. All cases retrospectively reviewed using World...