A5048889087- HIV-related health complications and treatments
- Herpesvirus Infections and Treatments
- Streptococcal Infections and Treatments
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Vaccine Coverage and Hesitancy
- Inflammatory Bowel Disease
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Otolaryngology and Infectious Diseases
- Geriatric Care and Nursing Homes
- Acute Kidney Injury Research
- Central Venous Catheters and Hemodialysis
- Antimicrobial Resistance in Staphylococcus
- Childhood Cancer Survivors' Quality of Life
- Pediatric health and respiratory diseases
- Systemic Lupus Erythematosus Research
- Blood disorders and treatments
- Dementia and Cognitive Impairment Research
- Hematological disorders and diagnostics
- Health, Environment, Cognitive Aging
- Neurological and metabolic disorders
- Poxvirus research and outbreaks
University Hospital of Geneva
2014-2024
University of Geneva
2015-2024
Swiss Finance Institute
2024
Mike O'Callaghan Federal Medical Center
2019
Live-attenuated vaccines are currently contraindicated in solid-organ transplant recipients. However, the risk of vaccine-preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver recipients with measles IgG antibodies <150 IU/L (below seroprotection threshold) received measles-mumps-rubella vaccine (MMR) at a median 6.3 years posttransplantation (interquartile range, 4.0 to 10.9). A...
INTRODUCTION: Patients with inflammatory bowel disease (IBD) are predisposed to pneumococcal infections due their underlying and iatrogenic immunosuppression. Vaccination the 13-valent conjugated vaccine (PCV13) is recommended, but poor take-up few data available. We performed an open-label, phase IV, multicenter study evaluate safety immunogenicity of PCV13 in adults IBD analyze influence immunomodulating treatments on anti-pneumococcal seroresponses. METHODS: enrolled 306 patients from...
Lipodystrophy (LD) is a frequent adverse event of combination antiretroviral therapy (ART) and occurs mainly in patients exposed to first-generation drugs. The aim this study was explore measure the interaction between LD, mental health, quality life human immunodeficiency virus (HIV) positive individuals seen metabolic clinic. We conducted single-site cross-sectional including all HIV-infected attending LIPO group metabolism day clinic at University Hospitals Geneva, Switzerland January 31,...
Chickenpox is a highly contagious vaccine-preventable disease that can lead to severe complications, especially in immunocompromised patients. Varicella-zoster virus (VZV) vaccine appears be safe and immunogenic pediatric solid organ transplant recipients, but there are few data on the long-term vaccine-induced seroprotection.In this prospective interventional study, we offered 2 doses of VZV all eligible nonseroprotected children seen 1 year after liver transplant. Vaccine responses were...
Abstract The efficacy of antibiotic therapy for group A streptococcus (GAS) pharyngitis is debated. role antibiotics in preventing complications seems limited, with the main potential benefit being symptom duration reduction. Our study aimed to evaluate whether a placebo non-inferior amoxicillin reducing fever duration. We randomized 88 children between 3 and 15 years age presenting acute symptoms positive rapid antigen detection test GAS receive 6-day treatment either ( n = 46) or 42)....
Lower respiratory tract infections (LRTI) are often caused by Streptococcus pneumoniae (Spn) and can be recurrent in 8% of children older than 2 years age. Spn is recognized pattern-recognition receptors (PRRs) the innate immune system, particular toll-like (TLRs) 4. To assess whether a defect somewhere along this TLR signaling pathway increases susceptibility to pneumococcal LRTI, we conducted prospective case-control study with 88 healthy individuals 45 LRTI aged 2-5 old. We examined cell...
Introduction Morphological and metabolic complications in HIV patients on antiretroviral therapy remain a challenge. While new cases of lipoatrophy (LA) disappear, irreducible central lipohypertrophy (LH) require highly specialized management. We described day hospital dedicated to lipodystrophy (LD) disorders treatment Geneva, Switzerland, with focus LH. Materials Methods The “Groupe Lipo & Metabolism” is multidisciplinary consultation where undergo standard evaluation including...
Abstract In pLT recipients, the advantages of ICVCs need to be weighed against risk complications. This single‐center retrospective study aimed review ICVC complications in our cohort recipients. We performed chart reviews patients having undergone transplant between 01/2000 and 03/2014 who underwent placement either before or after LT . identified 100 85 patients. Overall observation time was 90 470 catheter‐days. There no difference catheter lifespan those inserted pre‐ post‐transplant;...
Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date their immunizations.This study aims review vaccination status evaluate whether age, type, or treatment regimen could predict the absence seroprotection against selected vaccine-preventable in adults IBD.Cross-sectional using questionnaire, immunization records review, assessment tetanus-specific, varicella-specific, measles-specific immunoglobulin G concentrations....
There have been concerns that the COVID-19 pandemic and measures used to contain it impacted cognitive health of older adults. We therefore examined prevalence subjective decline, its associated risk factors consequencs, among dementia-free adults 2 years into in Switzerland.
Liver transplantation (LT) recipients are susceptible to infections, including measles. Concerns about the safety and efficacy of live-attenuated vaccines, such as measles-mumps-rubella (MMR) vaccine, have led hesitancy among providers in administering them immunocompromised patients. This 9-year interventional study assessed seroprotection against measles following MMR vaccination pediatric LT recipients. Of 119 participants enrolled, 60 (50%) were seroprotected after transplantation. Among...
Population Medicine considers the following types of articles:• Research Papers -reports data from original research or secondary dataset analyses.• Review -comprehensive, authoritative, reviews within journal's scope.These include both systematic and narrative reviews.• Short Reports -brief reports research.• Policy Case Studies articles on policy development at a regional national level.• Study Protocols -articles describing protocol study.• Methodology -papers that present different...