A5089224614- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Pediatric health and respiratory diseases
- COVID-19 Impact on Reproduction
- Biosensors and Analytical Detection
- COVID-19 and Mental Health
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Viral Infections and Immunology Research
- SARS-CoV-2 detection and testing
- COVID-19 and healthcare impacts
- Multiple Sclerosis Research Studies
- Kawasaki Disease and Coronary Complications
University of Regensburg
2020-2022
Kinderklinik Regensburg
2021
Abstract Background Worldwide, the number of SARS‐CoV‐2 infections is increasing. Serological immunoglobulin tests may help to better understand development immune mechanisms against in COVID‐19 cases and exposed but asymptomatic individuals. The aim this study was investigate exposure SARS‐CoV‐2, symptoms, antibody responses a large sample healthcare workers following outbreak. Methods A outbreak among staff members major German children's women's hospital followed by massive RT‐PCR...
Abstract Background Serum neurofilament light chain (sNfL) is an established biomarker of neuro-axonal damage in multiple neurological disorders. Raised sNfL levels have been reported adults infected with pandemic coronavirus disease 2019 (COVID-19). Levels children COVID-19 not as yet reported. Objective To evaluate whether elevated contracting COVID-19. Methods Between May 22 and July 22, 2020, a network outpatient pediatricians Bavaria, Germany, the Coronavirus antibody screening from...
Asthma and allergies are complex, chronic inflammatory diseases in which genetic environmental factors crucial. Protection against asthma allergy development the context of farming environment is established by early animal contact, unpasteurized milk consumption gut microbiota maturation. The human β-defensin 2 (hBD-2) a host defense peptide present almost exclusively epithelial tissues, with pronounced immunomodulatory properties, has recently been shown to ameliorate IBD models. We...
Background: Children and youth are affected rather mildly in the acute phase of COVID-19 thus, SARS-CoV-2 infection may easily be overlooked. In light current discussions on vaccinations children it seems necessary to better identify who immune against due a previous understand related reactions children. Methods: cross-sectional design, aged 1-17 were recruited through primary care pediatricians for study (a) randomly, if they had an appointment regular health check-up or (b) parents...
Background: Children are affected rather mildly by the acute phase of COVID-19, but predominantly in children and youths, potentially severe life threatening pediatric multiorgan immune syndrome (PMIS) occurs later on. To identify at risk early on, we searched for antibodies against SARS-CoV-2 mild symptoms PMIS those with high levels antibodies. Methods: In a cross-sectional design, aged 1-17 were recruited through primary care pediatricians study (a), if they had an appointment regular...
Background: Antigen tests for SARS-CoV-2 testing are rapid and inexpensive but usually have lower sensitivity than RT-qPCR only validated nasopharyngeal/throat swabs; the latter considered gold standard in terms of material collection not tolerated by patients with frequent sampling. The present study, therefore, investigates extent to which antigen is comparable from an easily obtained gargle solution compared nasopharyngeal swabs. Methods: performance a high-quality POC fluorescence immune...
<b>Background:</b> Asthma and allergies are complex diseases caused by gene-environment interplay. Human β-defensin 2 (hBD-2) is a host defense peptide secreted epithelial cells with immunomodulatory effects which was shown to improve asthma IBD in mice. <b>Objectives:</b> We hypothesized that adequate hBD-2 production crucial for prevention of allergy coding genes (<i>DEFB4A</i> -<i>B</i>) variants could play role disease development. <b>Methods:</b> Single nucleotide polymorphisms (SNPs)...