A5047460455- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 detection and testing
- Drug Transport and Resistance Mechanisms
- Biosensors and Analytical Detection
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Respiratory viral infections research
- MicroRNA in disease regulation
University of Regensburg
2021-2023
Background: Opening schools and keeping children safe from SARS-CoV-2 infections at the same time is urgently needed to protect direct indirect consequences of COVID-19 pandemic. To achieve this goal, a safe, efficient, cost-effective testing system for in addition standard hygiene measures necessary. Methods: We implemented screening WICOVIR concept southeast Germany, which based on gargling home, pooling samples schools, assessment by pool rRT-PCR, performed decentralized numerous...
Microglia are the resident immune cells of central nervous system. Upon stimulus presentation, microglia polarize from a resting to an activated state. Microglial translocator protein 18 kDa (TSPO) is considered marker inflammation. Here, we characterized role TSPO by investigating impact deficiency on human microglia. We used knockout (TSPO−/−) variants C20 cell line. found significant reduction in TSPO-associated VDAC1 TSPO−/− compared control cells. Moreover, assessed calcium levels and...
Microglia are the resident immune cells of central nervous system. Upon stimulus presentation microglia polarize from a resting to an activated state. Microglial translocator protein 18 kDa (TSPO) is considered as marker inflammation. Here, we characterized role TSPO by investigating impact deficiency on human microglia. We used knockout (TSPO-/-) variants C20 cell line. found significant reduction in TSPO-associated VDAC1 TSPO-/- compared control cells. Moreover, assessed calcium levels and...
Background: Antigen tests for SARS-CoV-2 testing are rapid and inexpensive but usually have lower sensitivity than RT-qPCR only validated nasopharyngeal/throat swabs; the latter considered gold standard in terms of material collection not tolerated by patients with frequent sampling. The present study, therefore, investigates extent to which antigen is comparable from an easily obtained gargle solution compared nasopharyngeal swabs. Methods: performance a high-quality POC fluorescence immune...