A5054799649- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Respiratory Support and Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Nosocomial Infections in ICU
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Pharmacological Effects and Toxicity Studies
- Blood disorders and treatments
- Health and Wellbeing Research
- Orthopedic Surgery and Rehabilitation
- Patient-Provider Communication in Healthcare
- Nitric Oxide and Endothelin Effects
- Metabolism and Genetic Disorders
- Glioma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Monoclonal and Polyclonal Antibodies Research
- Epilepsy research and treatment
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Family and Disability Support Research
- Family Support in Illness
- Patient Satisfaction in Healthcare
- Parasites and Host Interactions
Novartis (France)
2024
Novartis (United States)
2024
Stanford University
2018-2023
VA Palo Alto Health Care System
2019-2023
Stanford Medicine
2021
Palo Alto University
2018-2019
University of Connecticut
2014-2017
University of Hartford
2015
UConn Health
2015
Catholic Medical Center
2015
Abstract The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8 + T cells have been described RA, their function pathogenesis remains unclear. Here we perform single cell transcriptome receptor (TCR) sequencing derived from anti-citrullinated protein antibodies (ACPA)+ RA blood. We identify GZMB subpopulations containing large clonal lineage expansions express cytotoxic tissue homing...
To understand how the COVID-19 pandemic has affected caregivers, we assessed its perceived impact on caregiving through a new measure: Caregiver Limitations Scale (CCLS-9), in Spanish and English. We also compared levels of caregiver self-efficacy burden pre-COVID-19 early pandemic. administered surveys via internet to convenience sample caregivers January 2020 (pre-pandemic, n = 221) April-June (English, 177 samples, 144) assess self-efficacy, depression, pain, stress. used explore validity...
Abstract Rheumatoid arthritis (RA) and psoriatic (PsA) are two distinct autoimmune diseases that manifest with chronic synovial inflammation. Here, we show CD4 + T cells from patients RA PsA have increased expression of the pore-forming calcium channel component ORAI3, thereby increasing activity arachidonic acid-regulated calcium-selective (ARC) making sensitive to acid. A similar increase does not occur in systemic lupus erythematosus. Increased ORAI3 transcription is caused by reduced...
To determine the incidence of osteoarthrits (OA) in patients with atopic disease compared matched non-exposed patients.We conducted a retrospective cohort study propensity score matching using claims data from Optum's de-identified Clinformatics Data Mart (CDM) (January 2003 to June 2019) and electronic health record Stanford Research Repository (STARR) 2010 December 2020). We included adult without pre-existing OA or inflammatory arthritis who were exposed non-exposed. The primary outcome...
Metformin may have a protective association against developing osteoarthritis (OA), but robust epidemiological data are lacking.To determine the risk of OA and joint replacement in individuals with type 2 diabetes treated metformin compared sulfonylurea.This retrospective cohort study used claims from Optum deidentified Clinformatics Data Mart Database between December 2003 2019. Participants included aged 40 years or older at least 1 year continuous enrollment diabetes. Individuals prior...
This paper describes the development and evaluation of a short caregiving self-efficacy measure. The self-administered 8-item Caregiver Self-Efficacy Scale (CSES-8) was developed to reflect components typical caregiver support interventions be practical for inclusion in future research. We administered CSES-8 2 samples: participants an intervention caregivers persons with cognitive disabilities, voluntary online survey adults. evaluated completion rate, item-scale correlations, reliability,...
Abstract BACKGROUND AND AIMS IgA nephropathy (IgAN) is the most common primary glomerulonephritis in developed world. Up to 40% of patients with IgAN are at risk progressing end-stage kidney disease (ESKD), proteinuria being a strong predictor progression. Treatments that reduce accompanied by eGFR preservation and improved outcomes.[1] Endothelin A (ETA) receptor activation key driver proteinuria, inflammation fibrosis glomerular diseases.[2] Therefore, ETA blockade has potential be...
Endothelin A (ETA) receptor activation drives proteinuria, inflammation, and fibrosis in patients with glomerular diseases. Atrasentan, a potent selective ETA antagonist, represents potential therapy to reduce proteinuria preserve kidney function IgA nephropathy (IgAN) other AFFINITY is global, phase 2, open-label basket study evaluate the efficacy safety of atrasentan adult IgAN, Alport syndrome, focal segmental glomerulosclerosis, diabetic disease.
A remote (telephone and tool kit) chronic pain program was studied using the RE-AIM (reach, effectiveness, adoption, implementation, maintenance) framework. This 6-week pilot took place in underserved communities Cleveland, Ohio. We determined reach by diversity of population, nearly 50% Black mostly low income. Effectiveness over 7 weeks shown with validated instruments (depression, pain, sleep, quality life, self-rated health, self-efficacy). Changes depression, self-efficacy were...
We propose a power-performance trade off methodology for microprocessors. An instruction named slowdown low power (SLOP) is introduced. Functionally, it resembles the conventional NOP but requires power-specific hardware implementation. Depending upon reduction requirement, adequate number of SLOP's are automatically inserted in stream by management hardware. While processing SLOP, additional control signals generated various units; ALU powered down, caches put drowsy mode, and register file...
Several rheumatologic conditions including systemic lupus erythematosus, antiphospholipid antibody (APS) syndrome, rheumatoid arthritis, and scleroderma are known risk factors for stroke. The of hemorrhagic transformation after an acute ischemic stroke (AIS) in these patients is not known.We queried the Nationwide Inpatient Sample (NIS) data between 2010 2012 with ICD 9 diagnostic codes AIS. primary outcome was development transformation. Multivariate predictors were identified a logistic...
While the success or failure of carpal tunnel release ultimately depends on interplay a wide array factors, broad understanding normal anatomy accompanied by awareness possible variations individual structures that make up its contents is crucial to optimizing surgical outcomes. anatomic variants such as extension flexor digitorum muscle bellies have been described cause primary syndrome (CTS), there no reports depicting association with recurrent CTS following initially successful release,...
Metastatic and unresectable medullary thyroid carcinoma (MTC) is often difficult to treat as it relatively unresponsive radiation conventional chemotherapy. This emphasizes the importance of development targeted therapies for advanced MTC. Vandetanib was approved by US Food Drug Administration treatment symptomatic or progressive MTC in patients with disease April 2011. therapy proved be a breakthrough management We review efficacy safety this novel other treatments that are being evaluated disease.
Endothelin A (ETA) receptor activation drives proteinuria, kidney inflammation and fibrosis in IgA nephropathy (IgAN). Atrasentan, a potent selective ETA antagonist, is potential therapy to reduce proteinuria preserve function patients with IgAN. Interim results from the IgAN cohort of open-label AFFINITY study demonstrated atrasentan was well tolerated resulted clinically meaningful reductions at 12 24 weeks. The ongoing ALIGN (NCT04573478) global, phase 3, randomized, double-blind,...