A5014886426- Spinal Cord Injury Research
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Muscle activation and electromyography studies
- Nerve Injury and Rehabilitation
- Urinary Bladder and Prostate Research
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Spinal Dysraphism and Malformations
- Heart Rate Variability and Autonomic Control
- Prosthetics and Rehabilitation Robotics
- Musculoskeletal pain and rehabilitation
- Neuroscience of respiration and sleep
- Traumatic Brain Injury Research
- Balance, Gait, and Falls Prevention
- Anesthesia and Pain Management
- Trauma Management and Diagnosis
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular and exercise physiology
- Spinal Fractures and Fixation Techniques
- Cardiac Arrest and Resuscitation
- Pelvic floor disorders treatments
University of Louisville
2016-2025
Neurological Surgery
2016-2025
Rehabilitation Institute of Michigan
2015-2025
Kessler Foundation
2009-2025
Division of Undergraduate Education
2024
University of Louisville Hospital
2008-2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2020
KentuckyOne Health
2014-2019
Kentuckiana Pulmonary Associates
2017
University of Kentucky
2012
Previously, we reported that one individual who had a motor complete, but sensory incomplete spinal cord injury regained voluntary movement after 7 months of epidural stimulation and stand training. We presumed the residual pathways were critical in this recovery. However, now report three more individuals occurred with immediately implant even two diagnosed complete lesion. demonstrate neuromodulating circuitry stimulation, enables completely paralysed to process conceptual, auditory visual...
Harkema, Susan J., Seanna L. Hurley, Uday K. Patel, Philip S. Requejo, Bruce H. Dobkin, and V. Reggie Edgerton. Human lumbosacral spinal cord interprets loading during stepping. J. Neurophysiol. 77: 797–811, 1997. Studies suggest that the human can generate steplike oscillating electromyographic (EMG) patterns, but it remains unclear to what degree these efferent patterns depend on phasic peripheral sensory information associated with bilateral limb movements loading. We examined role of...
Many individuals with spinal cord injury (SCI) do not regain their ability to walk, even though it is a primary goal of rehabilitation. Mammals thoracic transection can relearn step hind limbs on treadmill when trained sensory input associated stepping. If humans have similar neural mechanisms for locomotion, then providing comparable training may promote locomotor recovery after SCI. We used designed provide information locomotion improve stepping and walking in adults Four SCIs, mean...
Persons with motor complete spinal cord injury, signifying no voluntary movement or sphincter function below the level of injury but including retention some sensation, do not recover independent walking. We tested intense locomotor treadmill training weight support and simultaneous epidural stimulation in four patients 2.5 to 3.3 years after traumatic failure improve alone. Two patients, one damage mid-cervical region high-thoracic region, achieved over-ground walking (not on a treadmill)...
The interaural time difference (ITD) is a cue for localizing sound source along the horizontal plane and first determined in nucleus laminaris (NL) birds. Neurons NL are tonotopically organized, such that ITDs processed separately at each characteristic frequency (CF). Here, we investigated excitability coincidence detection of neurons tonotopic axis NL, using chick brainstem slice preparation. Systematic changes with CF were observed morphological electrophysiological properties neurons....
Locomotor training using body weight support on a treadmill and manual assistance is promising rehabilitation technique following neurological injuries, such as spinal cord injury (SCI) stroke. Previous robots that automate this impose constraints naturalistic walking due to their kinematic structure, are typically operated in stiff mode, limiting the ability of patient or human trainer influence stepping pattern. We developed pneumatic gait robot allows for full range natural motion legs...
A prospective, multicenter phase I trial was undertaken by the North American Clinical Trials Network (NACTN) to investigate pharmacokinetics and safety of, as well obtain pilot data on, effects of riluzole on neurological outcome in acute spinal cord injury (SCI). Thirty-six patients, with ASIA impairment grades A-C (28 cervical 8 thoracic) were enrolled at 6 NACTN sites between April 2010 June 2011. Patients received 50 mg PO/NG twice-daily, within 12 h SCI, for 14 days. Peak trough plasma...
Background. The Spinal Cord Injury Locomotor Trial (SCILT) compared 12 weeks of step training with body weight support on a treadmill (BWSTT) that included overground practice to defined but more conventional mobility intervention (CONT) in patients incomplete traumatic SCI within 8 onset. No previous studies have reported walking-related outcomes during rehabilitation. Methods. This single-blinded, randomized trial entered 107 American Association (ASIA) C and D 38 ASIA B lesions between C5...
The use of locomotor training with a body-weight-support system and treadmill (BWST) manual assistance has increased in rehabilitation. purpose this case report is to describe the process for retraining walking person an incomplete spinal cord injury (SCI) using BWST transferring skills from overground assessment community ambulation.Following discharge rehabilitation, man SCI at C5-6 American Spinal Injury Association (ASIA) Impairment Scale classification D participated 45 sessions...
To improve clinicians' ability to predict outcome after spinal cord injury (SCI) and help classify patients within clinical trials, we have created a novel prediction model relating acute imaging information functional at 1 year. Data were obtained from two large prospective SCI datasets. Functional independence measure (FIM) motor score year follow-up was the primary outcome, (score ≥ 6 for each FIM item) secondary outcome. A linear regression with modeled relative predictors 3 days of...
Sensory and motor complete spinal cord injury (SCI) has been considered functionally resulting in permanent paralysis with no recovery of voluntary movement, standing or walking. Previous findings demonstrated that lumbosacral epidural stimulation can activate the neural networks one individual complete, but sensory incomplete SCI, who achieved full body weight-bearing independent knee extension, minimal self-assistance for balance external assistance facilitating hip extension. In this...
Epidural stimulation (ES) of the lumbosacral spinal cord has been used to facilitate standing and voluntary movement after clinically motor-complete spinal-cord injury. It seems importance examine how epidurally evoked potentials are modulated in circuitry projected various motor pools. We hypothesized that chronically implanted electrode arrays over can be assess functionally linked specific The purpose this study was investigate functional topographic organization compound induced by...
Abstract The prognosis for recovery of motor function in complete spinal cord injured (SCI) individuals is poor. Our research team has demonstrated that lumbosacral epidural stimulation (scES) and activity-based training can progressively promote the volitional leg movements standing with chronic clinically SCI. However, scES was required to perform these tasks. Herein, we show progressive voluntary movement without an individual chronic, SCI throughout 3.7 years interventions utilizing...
Object The aim of this multicenter, prospective study was to determine the spectrum, incidence, and severity complications during initial hospitalization patients with spinal cord injury. Methods conducted at 9 university-affiliated hospitals that comprise clinical centers North American Clinical Trials Network (NACTN) for Treatment Spinal Cord Injury. population comprised 315 admitted NACTN between June 25, 2005, November 2, 2010, who had Injury Association (ASIA) Impairment Scale grades...
Individuals affected by motor complete spinal cord injury are unable to stand, walk, or move their lower limbs voluntarily; this diagnosis normally implies severe limitations for functional recovery. We have recently shown that the appropriate selection of epidural stimulation parameters was critical promoting full-body, weight-bearing standing with independent knee extension in four individuals chronic clinically paralysis. In current study, we examined effects stand training and subsequent...