A5103237399- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury Research
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Liver Diseases and Immunity
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Sarcoidosis and Beryllium Toxicity Research
- Cholinesterase and Neurodegenerative Diseases
- Neurosurgical Procedures and Complications
- Analytical Chemistry and Chromatography
- Bone and Joint Diseases
- Psychedelics and Drug Studies
- Forensic Toxicology and Drug Analysis
Cornell University
2020-2024
Weill Cornell Medicine
2020-2024
Presbyterian Hospital
2024
New York Hospital Queens
2024
NewYork–Presbyterian Hospital
2024
MIND Research Institute
2020-2023
New York University
2016-2022
Universidad Nacional
2016
Abstract The glymphatic system is a perivascular fluid clearance system, most active during sleep, considered important for clearing the brain of waste products and toxins. Glymphatic failure hypothesized to underlie protein deposition in neurodegenerative disorders like Alzheimer’s disease. Preclinical evidence suggests that functioning also essential recovery from traumatic injury, which involves release debris toxic proteins need be cleared brain. In cross-sectional observational study,...
Summary In animal models, inflammation is both a cause and consequence of seizures. Less known about the role in human epilepsy. We performed positron emission tomography ( PET ) using radiotracer sensitive to brain patient with frontal epilepsy ~36 h after seizure as well during seizure‐free period. When statistically compared group 12 matched controls, patient's scans identified (supplementary motor area) region increased corresponding his clinically defined focus, but postseizure scan...
Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease Alzheimer's disease. An emerging biomarker BBB water exchange rate (kW) as measured by diffusion-weighted arterial spin labeling (DW-ASL) MRI. We developed an improved DW-ASL sequence for Quantitative Permeability Mapping evaluated whole brain region-specific kW in cohort 30 adults without dementia across the age spectrum. In this cross-sectional study, we found...
There is growing recognition that chronic liver conditions influence brain health. The impact of fibrosis on dementia risk was unclear. We evaluated the association between and incident in a cohort study.
Our objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20-80 years study the effect of aging on parenchymal CSF fraction (CSFF), a potential measure subvoxel space.A total 60 volunteers (age range, 22-80 years) were enrolled. Voxel-wise maps short-T2 myelin water (MWF), intermediate-T2 intra/extra-cellular (IEWF), and long-T2 CSFF obtained using fast acquisition with spiral trajectory adiabatic T2prep (FAST-T2) sequence three-pool non-linear least...
Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is a novel MRI method for assessing brain interstitial fluid dynamics, potentially indexing glymphatic function. Failed clearance implicated in Alzheimer’s disease (AD) pathophysiology. We assessed the contribution of age and female sex (strong AD risk factors) to DTI-ALPS index healthy subjects. also first time effect head size. In accord with prior studies, we show reduced aging, men compared women. However, size may be major...
Cerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage in older patients. Although other types intracranial can occur conjunction with CAA-related hemorrhage, the association between CAA and subtypes particularly absence remains poorly understood.
Abstract Introduction We hypothesized that liver fibrosis is associated with worse cognitive performance and corresponding brain imaging changes. Methods examined the association of cognition parameters in UK Biobank study. Liver was assessed using Fibrosis‐4 (FIB‐4) score. The primary outcome digit symbol substitution test (DSST); secondary outcomes were additional executive function/processing speed memory tests. Imaging hippocampal, total brain, white matter hyperintensity (WMH) volumes....
White matter dysfunction and degeneration have been a topic of great interest in healthy pathological aging. While ex vivo studies investigated age-related changes canines, little canine aging research exists. Quantitative diffusion MRI such as tensor imaging (DTI) has demonstrated neurodegenerative white humans. However, this method not applied adapted to populations. This study aimed test the hypothesis that frequently reported human are also found aged canines. The used Tract Based...
<h3>SUMMARY:</h3> The clinical standard of care in the diagnosis neurodegenerative diseases relies on [<sup>18</sup>F] FDG-PET/CT or PET MR imaging. Limitations FDG-PET include cost, need for IV access, radiation exposure, and availability. Arterial spin-labeling imaging has been shown research settings to be useful as a proxy differentiating Alzheimer disease from frontotemporal dementia. However, it is not yet widely used practice, except cerebrovascular disease. Here, we present 7...
Abstract A high performance liquid chromatographic method involving diode array detection (HPLC–DAD) is proposed for the determination of cocaine and benzoylecgonine in human hair. Samples were washed, dried, subjected to enzyme hydrolysis liquid–liquid extraction Toxitubes A® prior analysis on a Nova‐Pak C18 (150 × 3.9 mm) column with 70:30 (v/v) methanol–0.02 M phosphate buffer pH 7, at constant flow‐rate 0.4 mL/min as mobile phase, articaine reference compound. The detector response was...
Abstract Background An elevated neutrophil‐lymphocyte ratio (NLR) has been associated with Alzheimer’s disease (AD). However, an NLR also implicated in many other conditions that are risk factors for AD, prompting investigation into whether the is directly linked AD pathology or a result of underlying comorbidities. Method We explored relationship between and biomarkers cerebrospinal fluid (CSF) cognitively unimpaired (CU) subjects. Adjusting sociodemographics, APOE4, common comorbidities,...
Abstract Background The accumulation of tau tangles and beta‐amyloid (Aβ) are hallmarks Alzheimer's disease (AD). Despite the hypothesis that Aβ may trigger spread across remote brain regions, specific pathological processes remain unclear. Methods Our study utilized 18F‐Florbetaben positron emission tomography (PET), 18F‐MK6240 PET, resting‐state functional magnetic resonance imaging (rs‐fMRI). We included 361 healthy control (HC) subjects from Northern Manhattan Study Metabolism Mind...
Abstract Background Early detection of Alzheimer’s disease (AD) can improve prognosis, given new anti‐amyloid therapies. Both positron emission tomography (PET) and magnetic resonance (MR) imaging biomarkers are currently used (1). 48F‐Fluorodeoxyglucose‐PET (FDG‐PET) detect neurodegeneration‐related hypometabolism but is costly not easily accessible (2). Cerebral blood flow (CBF), assessed using arterial spin labelling (ASL‐MRI), closely linked to metabolism in neurodegenerative In a recent...
Abstract Background Liver fibrosis is a chronic liver condition that, though frequently subclinical, has widespread systemic effects. We hypothesized that associated with worse cognitive performance and corresponding brain imaging changes. Method examined the association of cognition volumes among adults in UK Biobank study, which prospectively enrolled approximately 500,000 people starting 2007 subsequently collected test MRI data for some participants. included participants available...
Abstract Background Traumatic brain injury (TBI) is a well‐established risk factor for Parkinson’s disease (PD), though the nature of this relationship remains unclear. This study examines TBI’s with AAO and survival following PD onset among participants relation neuropathology in an autopsy cohort. Methods retrospective observational using National Alzheimer’s Coordinating Centers (NACC) database. TBI status was assessed based on self‐reported history. Clinicians estimate used determining...
Abstract White matter dysfunction and degeneration have been a topic of great interest in healthy pathological aging. While ex vivo studies investigated age-related changes canines, little canine aging research exists. Quantitative diffusion MRI such as tensor imaging (DTI) has demonstrated neurodegenerative white humans. However, this method not applied adapted to populations. This study aimed test the hypothesis that frequently reported human are also found aged canines. The used Tract...
Abstract Background There is growing recognition of the role chronic liver disease in brain health, but impact fibrosis on dementia risk was unclear. We evaluated association between and incident using data from a large prospective cohort study. Methods performed analysis UK Biobank study, which prospectively enrolled approximately 500,000 adults starting 2007 continues to follow them. Liver defined validated cutoffs Fibrosis-4 (FIB-4) score. The primary outcome dementia, ascertained...