A5071615013- Mitochondrial Function and Pathology
- Obstructive Sleep Apnea Research
- Diabetes Management and Research
- Neuroscience of respiration and sleep
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
- Sleep and related disorders
- Metabolism and Genetic Disorders
- Respiratory Support and Mechanisms
- Metabolism, Diabetes, and Cancer
- Neurological diseases and metabolism
- Microbial Metabolic Engineering and Bioproduction
- Tracheal and airway disorders
- Fatty Acid Research and Health
- Dysphagia Assessment and Management
- Metabolomics and Mass Spectrometry Studies
- Neuroblastoma Research and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Wireless Body Area Networks
- Diabetes and associated disorders
Beth Israel Deaconess Medical Center
2022-2024
Harvard University
2022-2024
Howard Hughes Medical Institute
2024
SUNY Downstate Health Sciences University
2013-2022
New York University
2012-2014
Abstract Compelling evidence shows that brown and beige adipose tissue are protective against metabolic diseases 1,2 . PR domain-containing 16 (PRDM16) is a dominant activator of the biogenesis adipocytes by forming complex with transcriptional epigenetic factors therefore an attractive target for improving health 3–8 However, lack knowledge surrounding regulation PRDM16 protein expression hampered us from selectively targeting this pathway. Here we identify CUL2–APPBP2 as ubiquitin E3...
Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis tightly associated with increased energy expenditure, reduced body weight, and improved glucose homeostasis. However, human protective against type 2 diabetes, independent of weight. The mechanism underlying this dissociation remains unclear. Here, we report impaired mitochondrial catabolism branched-chain amino acids (BCAAs) in BAT, by deleting BCAA carriers (MBCs), caused...
Abstract Background: Patients with obstructive sleep apnea/hypopnea syndrome (OSAHS), even those generally compliant CPAP therapy, often intermittently discontinue CPAP. Study Objective: Examine the impact of withdrawal on sleep, disordered breathing (SDB), and daytime function in subjects varying severity OSAHS. Interventions: Forty-two (26M/16 F) OSAHS (AHI4% = 45.2 ± 35.5/h pretreatment) for 4 months were evaluated second night withdrawal. Sleep architecture, SDB indices,...
Adherence to CPAP therapy is low in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). The purpose of the present study was evaluate utility measures architecture and continuity on titration as predictors both short- long-term adherence.93 OSAHS (RDI 42.8 ± 34.3/h) underwent in-laboratory diagnostic polysomnography, titration, follow-up polysomnography (NPSG) CPAP. objectively monitored. Short-term (ST) adherence averaged over 14 days immediately following study. Long-term (LT)...
Mitochondria provide essential metabolites and adenosine triphosphate (ATP) for the regulation of energy homeostasis. For instance, liver mitochondria are a vital source gluconeogenic precursors under fasted state. However, regulatory mechanisms at level mitochondrial membrane transport not fully understood. Here, we report that liver-specific inner-membrane carrier SLC25A47 is required hepatic gluconeogenesis Genome-wide association studies found significant associations between fasting...
Management of hospitalized patients with type 2 diabetes mellitus (T2DM) presents unique challenges. Two recently released guidelines, one from the American Diabetes Association and other Endocrine Society, provide useful recommendations evidence review to inform care medical inpatients T2DM. These guidelines mostly agree, although there are slight differences in their recommendations. In these rounds, expert diabetologists discuss approach inpatient management T2DM, specifically regarding...
The authors examined magnitude/variability of residual sleep disordered breathing (SDB) at pressures around the therapeutic continuous positive airway pressure (CPAP), and described a multinight approach to CPAP titration/retitration consisting recording airflow summarizing SDB over multiple nights choosing an optimal from these summarized data.Prospective, single-center nonblinded study.Ten female/18 male patients with obstructive apnea-hypopnea syndrome (OSAHS) (respiratory disturbance...
Abstract Disclosure: A. DeMarsilis: None. C. Jiang: O. Lavrynenko: D. Motavalli: Musurakis: Z.H. Taxin: E.D. Rosen: Advisory Board Member; Self; Source Bio, Inc.. Consulting Fee; Novartis Pharmaceuticals, Gensaic. M.S. Irwig: Background: Ectopic Cushing’s Syndrome (CS) makes up 9-18% of ACTH-dependent CS cases, which fewer than 15% are attributed to pancreatic neuroendocrine tumors (1). Mixed non-neuroendocrine neoplasms (MiNENs) rare, aggressive carcinomas, often driven by high-grade...
<p dir="ltr">Continuous glucose monitoring (CGM) systems provide frequent measurements in interstitial fluid and have been used widely ambulatory settings for diabetes management. During the COVID-19 pandemic, regulators United States Canada temporarily allowed CGM to be hospitals with aim of reducing healthcare professional exposure limiting use personal protective equipment. As such, studies on hospital system possible. With improved sensor accuracy, there is increased interest usage...
<p dir="ltr">Continuous glucose monitoring (CGM) systems provide frequent measurements in interstitial fluid and have been used widely ambulatory settings for diabetes management. During the COVID-19 pandemic, regulators United States Canada temporarily allowed CGM to be hospitals with aim of reducing healthcare professional exposure limiting use personal protective equipment. As such, studies on hospital system possible. With improved sensor accuracy, there is increased interest usage...
ABSTRACT Mitochondria provide essential metabolites and ATP for the regulation of energy homeostasis. For instance, liver mitochondria are a vital source gluconeogenic precursors under fasted state. However, regulatory mechanisms at level mitochondrial membrane transport not fully understood. Here, we report liver-specific inner-membrane carrier, SLC25A47, which is required hepatic gluconeogenesis Genome-wide association studies found significant associations between SLC25A47 fasting...