A5072033320- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organometallic Complex Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Metal complexes synthesis and properties
- Obstructive Sleep Apnea Research
- Ferrocene Chemistry and Applications
- Coordination Chemistry and Organometallics
- Radiopharmaceutical Chemistry and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Sleep and related disorders
- Protein Tyrosine Phosphatases
- Sleep and Wakefulness Research
- Synthesis and characterization of novel inorganic/organometallic compounds
- interferon and immune responses
- Organometallic Compounds Synthesis and Characterization
- Galectins and Cancer Biology
- Cancer Treatment and Pharmacology
- Neuroscience of respiration and sleep
- Glycosylation and Glycoproteins Research
- Dysphagia Assessment and Management
- Environmental Policies and Emissions
- Cardiovascular Function and Risk Factors
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
Peterson Institute for International Economics
2022
Pfizer (Ireland)
2020
Wheaton College - Illinois
2017-2019
United States Army Medical Research Institute of Infectious Diseases
2012-2019
University College Dublin
2007-2010
To determine the effect of self-reported clinical diagnosis obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers (Aβ42, T-tau, P-tau) cognitively normal (NL), mild cognitive impairment (MCI), Alzheimer's disease (AD) elderly.
Abstract p ‐Methoxybenzyl‐substituted and benzyl‐substituted N‐heterocyclic carbene (NHC) [( 3a – c ) ( 6a )] precursors were synthesised from the reaction of 1 H ‐imidazole 1a ), 4,5‐dichloro‐1 1b ‐benzimidazole 1c with ‐methoxybenzyl bromide 2 benzyl 5 ). These NHC then treated silver(I) acetate to yield NHC–silver complexes [1,3‐bis(4‐methoxybenzyl)imidazol‐2‐ylidene]silver(I) 4a [4,5‐dichloro‐1,3‐bis(4‐methoxybenzyl)imidazol‐2‐ylidene]silver(I) 4b...
In three simple steps the anticancer drug bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) oxalate (oxali-titanocene Y) can be synthesised from commercially available starting materials. Oxali-titanocene Y shows twice cytotoxicity of cisplatin in pig kidney epithelial (LLC-PK) cells and is most cytotoxic titanocene known.
From the carbolithiation of 6-N,N-dimethylaminofulvene (3a) and different lithiated heterocycles (5-N-methylpyrazolyl, 2-thiazolyl, 2-N(N,N-dimethylamino)methylimidazolyl), corresponding lithium cyclopentadienide intermediate (4a−c) was formed. These three intermediates underwent a transmetalation reaction with TiCl4, resulting in dimethylamino-functionalized titanocenes 5a−c. When these were tested against LLC-PK cells, IC50 values obtained 53 61 μM for 5a 5b, respectively. The most...
Abstract From the reaction of 6‐(2‐fluoro‐4‐methoxyphenyl)fulvene ( 1a ), 6‐(3‐fluoro‐4‐methoxyphenyl)fulvene 1b ) and 6‐[4‐(trifluoromethoxy)phenyl]fulvene 1c with LiBEt 3 H, lithiated cyclopentadienide intermediates 2a – c were synthesised. These then transmetallated to vanadium VCl 4 yield benzyl‐substituted vanadocenes bis[(2‐fluoro‐4‐methoxybenzyl)cyclopentadienyl]vanadium(IV) dichloride 3a bis[(3‐fluoro‐4‐methoxybenzyl)cyclopentadienyl]vanadium(IV) 3b...
The para-methoxybenzyl-substituted titanocene oxalate (Oxali-Titanocene Y) was tested in vitro an antiangiogenesis assay against human umbilical vein endothelial cells, HUVEC, delivering IC50 value of 14 μM and a cytotoxicity the renal cancer CAKI-1, which demonstrated greater than 100 μM. Then Oxali-Titanocene Y given at 30 mg/kg/d, is maximum tolerable dose, on five consecutive days per week for three weeks to one cohort eight CAKI-1 tumor-bearing female NMRI:nu/nu mice, while second...
From the reaction of various 6-indolylfulvenes (1a−f) with Super Hydride (LiBEt3H), followed by transmetalation titanium tetrachloride (TiCl4), six indolyl-substituted titanocenes, bis[(1-methylindol-2-yl)cyclopentadienyl]titanium(IV) dichloride (3a), bis[(1-methyl-5-methoxyindol-2-yl)cyclopentadienyl]titanium(IV) (3b), a dihydrochloride derivative bis[(1-methyl-3-dimethylaminomethylindol-2-yl)cyclopentadienyl]titanium(IV) (3c), bis[(1-methylindol-3-yl)cyclopentadienyl]titanium(IV) (3d),...
Abstract From the reaction of Super Hydride (LiBEt 3 H) with 6‐(2‐fluoro‐4‐methoxyphenyl)fulvene ( 1a ), 6‐(4‐trifluoromethoxyphenyl)fulvene 1b and 6‐(3‐fluoro‐4‐methoxyphenyl)fulvene 1c ) lithiated cyclopentadienide intermediates 2a – c were synthesised. These then transmetallated to titanium TiCl 4 give benzyl‐substituted titanocenes bis[(2‐fluoro‐4‐methoxybenzyl)cyclopentadienyl]titanium(IV) dichloride 3a bis[(4‐trifluoromethoxybenzyl)cyclopentadienyl]titanium(IV) 3b...
Abstract From the carbolithiation of 1‐(cyclopenta‐2,4‐dien‐1‐ylidene)‐ N , ‐dimethylmethanamine (=6‐(dimethylamino)fulvene; 3 ) and different lithiated azaindoles 2 (1‐methyl‐7‐azaindol‐2‐yl, 1‐[(diethylamino)methyl]‐7‐azaindol‐2‐yl, 1‐(methoxymethyl)‐7‐azaindol‐2‐yl), corresponding lithium cyclopentadienide intermediates 4a – 4c were formed (7‐azaindole=1 H ‐pyrrolo[2,3‐ b ]pyridine). The latter underwent a transmetallation reaction with TiCl 4 resulting in (dimethylamino)‐functionalised...
Abstract BACKGROUND While locally advanced prostate cancer is initially treatable with androgen ablation, eventually cells develop a castrate‐resistant phenotype. Currently, there are no effective treatments for this form of the disease Docetaxel only providing small survival advantage. In study, effects novel derivatives titanocene dichloride on cell lines has been investigated. METHODS Cellular were assessed using crystal violet assay and clonogenic assay. Cell cycle apoptosis by propidium...
The well-known anticancer drug candidate bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (TitanoceneY) was reacted with sodium azide or potassium cyanate, thiocyanate selenocyanate in order to give pseudo-halide analogues 2a–d of TitanoceneY. 2b and 2c were characterised by single crystal X-ray diffraction, which confirmed the expected nitrogen binding cyanate titanium centre. All four titanocenes had their cytotoxicity investigated through preliminary vitro testing on LLC-PK...
From the carbolithiation of 6-morpholino fulvene (3) and different lithiated nitrogen containing heterocycles (2-N-methylimidazolyl, 2-N-(N,N-dimethylamino)methyl-imidazolyl, 2-N-methylindolyl), corresponding lithium cyclopentadienide intermediate (4a-c) was formed. These three intermediates underwent a transmetallation reaction with TiCl4 resulting in morpholino-functionalised titanocenes 5a-c. When these were tested against LLC-PK cells, IC50 values obtained 24, 36, 41 μM respectively. The...