The Japanese government approved COVID-19 vaccine booster doses in November 2021. However, intentions and readiness for vaccines among the general population were unknown. This survey measured vaccination. Among 6172 participants (53.2% female), 4832 (78.3%) accepted doses; 415 (6.7%) hesitated. Vaccination intention was associated with higher age, marital status, having children, underlying diseases, social norms. To evaluate vaccination, seven component (7C) vaccination scale employed,...

Coronavirus disease 2019 (COVID-19), first reported in December 2019, spread worldwide a short period, resulting numerous cases and associated deaths; however, the toll was relatively low East Asia. A genetic polymorphism unique to Asians, Aldehyde dehydrogenase 2 rs671, has been confer protection against infections.

Abstract Background The increase in the number of Internet users has increased dependence worldwide. In adolescents, this may interfere with sleep, which is important for development psychophysiological capabilities. However, few large-scale surveys have described relationship between addiction (IA) and sleep disturbance using standardized questionnaires. We conducted a survey one prefecture Japan to determine IA adolescents based on categories Young Diagnostic Questionnaire (YDQ). Methods...

Understanding vaccine hesitancy, considering the target region and phase, is an urgent issue to quell coronavirus disease (COVID-19) pandemic. This study aimed monitor COVID-19 hesitancy in Japanese population during three phases of approval introduction, evaluate association with confidence literacy. We conducted web-based cross-sectional surveys introduction: January 2021, before approval; June, start vaccination elderly; September, when about 70% was vaccinated at least one dose. There...

Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that most prevalent polymorphism aldehyde dehydrogenase 2 gene (

Abstract This study aims to examine the relationship of sleep (sleep duration, quality, and rhythm) with presenteeism in workers while controlling for other confounding factors. A total 2375 six Japanese companies received self-administered questionnaires from June November 2018. Information on duration was used evaluate quantity, Athens Insomnia Scale (AIS) workers’ engagement shift work determine their rhythms. We World Health Organization Work Performance Questionnaire presenteeism....

Internet addiction and poor mental health are two pervasive problems during adolescence. This study aimed to determine whether status exhibited a bidirectional relationship in which either variable could become risk factor for the onset of other.Longitudinal school-based survey with baseline sample 1547 students among 8 schools (10th graders) Japan surveyed 2015 followed up 1 year later. The located middle city. We assessed internet using Japanese version Diagnostic Questionnaire developed...

The purpose of the present study was to evaluate validity and reliability a Japanese version an electromagnetic hypersensitivity (EHS) questionnaire, originally developed by Eltiti et al. in United Kingdom. Using this EHS surveys were conducted on 1306 controls 127 self‐selected subjects Japan. Principal component analysis revealed eight principal symptom groups, namely, nervous, skin‐related, head‐related, auditory vestibular, musculoskeletal, allergy‐related, sensory, heart/chest‐related....

The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has required rapid action to control its spread and vaccines are a fundamental solution this pandemic. development of reliable serological tests monitor the antibody response disease is necessary for post-vaccination immune responses. Therefore, in study, anti-SARS-CoV-2 titers after first second doses were monitored using two different measurement systems, highly sensitive analytical platform chemiluminescent...

Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that most prevalent polymorphism aldehyde dehydrogenase 2 (ALDH2) gene, rs671, may be associated with an attenuated immune system. To test inverse relation between rs671 and antibody production after COVID-19 vaccination, levels anti-SARS-CoV-2 Spike protein S1 subunit (S1) IgG were repeatedly measured four months before vaccination BNT162b2 or mRNA-1273, in 88 Japanese workers students...

To clarify the incidence of predictive risk factors for poor mental health status in Japanese adolescents.In 2010, baseline surveys first-year junior and senior high school students were conducted at 10 randomly selected schools 14 Japan. After 2 years, follow-up on same students. For both surveys, a self-administered questionnaire about lifestyle, General Health Questionnaire-12 (GHQ-12), was provided to students.In total, 1,304 4,383 enrolled start study, 776 2,697 responded surveys. The...

Introduction Addresing vaccine hesitancy is considered an important goal in management of the COVID-19 pandemic. We sought to understand what factors influenced people, especially those initially hesitant, receive two or more doses within a year vaccine’s release. Methods conducted longitudinal Web-based observational studies 3,870 individuals. The surveys were at four different time points: January 2021, June September and December 2021. In baseline survey (January 2021), we assessed...

Background/Objectives: Low blood vitamin D levels have been linked to COVID-19 severity; however, data on the effects of vaccine immunogenicity remain limited. This study evaluated impact baseline serum 1α, 25-(OH)2 D, a bioactive form with controlled concentrations, response. Methods: From June September 2021, we measured active in 88 Japanese workers and students before vaccination BNT162b2 or mRNA-1273. We assessed SARS-CoV-2 spike protein S1 IgG IgM antigen-specific INF-γ-releasing cells...

Because we observed a reduced humoral immune response to the COVID-19 vaccine and subsequently discovered lower susceptibility in individuals carrying ALDH2 rs671 variant, hypothesized that is beneficial for cellular immunity against COVID-19. Using IFN-γ enzyme-linked immunospot (ELISPOT) assay, evaluated before after vaccination two subcohorts of previously reported cohort. Subcohort 1 (26 participants) had six repeated observations at baseline one three doses, whereas subcohort...

We previously reported a reduced humoral immune response to the COVID-19 vaccines. Subsequently, we observed lower susceptibility in individuals carrying

Parental willingness is a prerequisite for childhood immunization. The purpose of this study to evaluate whether parental vaccine readiness and using the modified Japanese 7C Readiness Scale can predict vaccination behavior. In December 2021, 2 months before approval COVID-19 children aged 5–11 years in Japan, we asked 1,190 parents such about their children's against scales online. consist 7 components, namely, confidence, complacency, constraints, calculation, collective...

Parental willingness is a prerequisite for childhood immunization. This study evaluated whether parental vaccination readiness and willingness, measured using the modified Japanese 7C Vaccination Readiness Scale, predicted behavior. In December 2021, 2 months before approval of COVID-19 children aged 5–11 years in Japan, we asked 1,190 parents this age groups about their intention regarding vaccinating against an online consisting seven components, namely, Confidence, Complacency,...

Background/Objectives: Although the protective effects of zinc against COVID-19 are documented, its impact on vaccine immunogenicity remains unknown. Methods: We conducted a prospective study involving cohort 79 Japanese individuals (aged 21–56 years; comprising three subcohorts) and measured their serum levels pre-vaccination anti-SARS-CoV-2 IgM/IgG pre- post-vaccination over 4 months. Results: Serum concentrations ranged 74–140 64–113 ug/dL in male female individuals, respectively, with...