A5018699556- SARS-CoV-2 and COVID-19 Research
- Alcohol Consumption and Health Effects
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Renin-Angiotensin System Studies
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Nuclear Receptors and Signaling
- Food Allergy and Anaphylaxis Research
- Metabolomics and Mass Spectrometry Studies
- Urticaria and Related Conditions
- Ion Transport and Channel Regulation
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Trace Elements in Health
- Redox biology and oxidative stress
- Dermatology and Skin Diseases
- Mast cells and histamine
- Endoplasmic Reticulum Stress and Disease
- Apelin-related biomedical research
- Asthma and respiratory diseases
- Psychology of Moral and Emotional Judgment
- SARS-CoV-2 detection and testing
- MicroRNA in disease regulation
Saga University
2022-2024
Kindai University
2004-2024
The Japanese government approved COVID-19 vaccine booster doses in November 2021. However, intentions and readiness for vaccines among the general population were unknown. This survey measured vaccination. Among 6172 participants (53.2% female), 4832 (78.3%) accepted doses; 415 (6.7%) hesitated. Vaccination intention was associated with higher age, marital status, having children, underlying diseases, social norms. To evaluate vaccination, seven component (7C) vaccination scale employed,...
Background: Although the mesenteric artery plays a key role in regulating peripheral blood pressure, molecular mechanisms that underlie development of essential hypertension are not yet fully understood. Materials and Methods: We explored candidate genes for using three related strains spontaneously hypertensive rats (SHRs) mimic human hypertension. In this study we used DNA microarrays, powerful tool studying genetic diseases, to compare gene expression SHR substrains: SHR, stroke-prone...
Understanding vaccine hesitancy, considering the target region and phase, is an urgent issue to quell coronavirus disease (COVID-19) pandemic. This study aimed monitor COVID-19 hesitancy in Japanese population during three phases of approval introduction, evaluate association with confidence literacy. We conducted web-based cross-sectional surveys introduction: January 2021, before approval; June, start vaccination elderly; September, when about 70% was vaccinated at least one dose. There...
Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that most prevalent polymorphism aldehyde dehydrogenase 2 gene (
Clarification of the genetic nature and more effective care for hypertension are required, given high incidences cardiovascular cerebrovascular mortality. Thus, we surveyed candidate genes with rat whole gene DNA microarrays using three novel methods. Gene expression analyses were conducted as follows: Method 1, types spontaneously hypertensive (SHR) substrains, SHR, stroke-prone SHR (SHRSP) malignant type SHRSP (M-SHRSP) used compared to normotensive Wistar Kyoto rats; 2, expressed between...
Diuretics, including thiazides and thiazide-like drugs, are commonly recommended for treating hypertension, though their precise mechanism of action is not fully understood. This study aimed to investigate the pharmacological effects trichloromethiazide (TCM) in malignant stroke-prone spontaneously hypertensive rats (M-SHRSP).
We examined gene expression profiles in rat adrenal glands using genome-wide microarray technology. Gene levels were determined four strains, including one normotensive strain [Wistar-Kyoto (WKY)] and three substrains derived from WKY rats: spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP) malignant SHRSP (M-SHRSP). This study represents the first attempt at microarrays to compare SHR, M-SHRSP glands, employing as controls. Expression measurements made these strains 6 9 weeks...
The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has required rapid action to control its spread and vaccines are a fundamental solution this pandemic. development of reliable serological tests monitor the antibody response disease is necessary for post-vaccination immune responses. Therefore, in study, anti-SARS-CoV-2 titers after first second doses were monitored using two different measurement systems, highly sensitive analytical platform chemiluminescent...
Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that most prevalent polymorphism aldehyde dehydrogenase 2 (ALDH2) gene, rs671, may be associated with an attenuated immune system. To test inverse relation between rs671 and antibody production after COVID-19 vaccination, levels anti-SARS-CoV-2 Spike protein S1 subunit (S1) IgG were repeatedly measured four months before vaccination BNT162b2 or mRNA-1273, in 88 Japanese workers students...
Background/Objectives: Although the protective effects of zinc against COVID-19 are documented, its impact on vaccine immunogenicity remains unknown. Methods: We conducted a prospective study involving cohort 79 Japanese individuals (aged 21–56 years; comprising three subcohorts) and measured their serum levels pre-vaccination anti-SARS-CoV-2 IgM/IgG pre- post-vaccination over 4 months. Results: Serum concentrations ranged 74–140 64–113 ug/dL in male female individuals, respectively, with...
Background/Objectives: Although the protective effects of zinc against COVID-19 are documented, its impact on vaccine immunogenicity remains unknown. Methods: We conducted a prospective study involving cohort 79 Japanese individuals (aged 21–56 years; comprising three subcohorts) and measured their serum levels pre-vaccination anti-SARS-CoV-2 IgM/IgG pre- post-vaccination over 4 months. Results: Serum concentrations ranged between 74–140 64–113 μg/dL in male female individuals, respectively,...
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