A5082308125- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Neuropeptides and Animal Physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Chronic Kidney Disease and Diabetes
- Acute Ischemic Stroke Management
- Aortic aneurysm repair treatments
- Influenza Virus Research Studies
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
- Adipose Tissue and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Receptor Mechanisms and Signaling
- Respiratory viral infections research
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Vascular Malformations Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Pelvic floor disorders treatments
- Dialysis and Renal Disease Management
- Regulation of Appetite and Obesity
- Nerve Injury and Rehabilitation
- Esophageal and GI Pathology
National Cerebral and Cardiovascular Center
2023-2025
Hiroshima University
2024-2025
Keio University
2017-2024
University Hospital and Clinics
2015-2024
Toho University Ohashi Medical Center
2011-2024
Toho University
2011-2024
University Medical Center
2015-2024
Kyorin University
2019-2024
Fukushima Medical University
2021-2024
Nagasaki University
2022-2024
Recently, thoracic aortic stent grafting has emerged as an alternative therapeutic modality for patients with aneurysms and dissections. However, its application been limited to descending distal the arch. We report our initial clinical experience of endovascular branched graft repair arch aneurysms.Endovascular Inoue grafts was attempted 15 dissections under local anesthesia (n=14) or general (n=1). Single-branched were used in 14 patients, a triple-branched one. The delivered through 22F...
Heart failure is a typical age-associated disease. Although age-related changes of heart are likely to predispose aged people failure, little known about the molecular mechanism cardiac aging.We analyzed in murine and manner which suppression p110alpha isoform phosphoinositide 3-kinase activity modified aging. Cardiac function declined old mice associated with expression senescence markers. Accumulation ubiquitinated protein lipofuscin, as well comprehensive gene profiling, indicated that...
Background House dust mite (HDM) is the major indoor allergen for allergic diseases such as rhinitis (AR) and asthma. Although sublingual immunotherapy a curative treatment HDM-induced AR, data from large-scale studies are limited. We evaluated efficacy safety of HDM tablets in adolescent adult patients (aged 12–64 years) with AR or without intermittent Methods In double-blind trial Japan, 968 subjects were randomized 1 : to 300 index reactivity (IR), 500 IR, placebo groups. The primary...
Aim: To examine and compare the predictive value of total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C), TC/HDL-C LDL-C/HDL-C ratios for future cardiovascular outcomes in general Japanese population.Methods: A 24,566 eligible participants aged 18 years or older, without disease, were enrolled through multiphase health screening divided into quartile groups based on levels ratios. Primary endpoints study definitive acute myocardial infarction (AMI) ischemic stroke,...
Recent studies indicate that, in people with diabetes or hypertension and the general population, low-grade albuminuria (LGA) below microalbuminuria threshold is a predictor for incidence of cardiovascular disease (CVD) mortality. However, it remains unclear whether LGA predicts risk CVD death nondiabetic normotensive individuals.A total 3599 individuals aged not less than 40 years from population who are free preserved glomerular filtration rate were followed all-cause death. was defined as...
Abstract Objective: To evaluate the safety and efficacy of ospemifene for treatment moderate to severe vaginal dryness in postmenopausal women with vulvovaginal atrophy (VVA). Methods: This 12-week, multicenter, double-blind phase 3 study randomized (aged 40-80 years) VVA as their most bothersome symptom daily oral 60 mg or placebo. Coprimary endpoints included changes from baseline week 12 percentages parabasal superficial cells, pH, severity versus placebo; other secondary were evaluated...
The precise time of stroke onset during sleep is difficult to specify, but this has a considerable influence on circadian variations onset.To investigate in situations at onset--that is, the waking state or sleep--and their differences among subtypes.12,957 cases first-ever diagnosed from Iwate Stroke Registry between 1991 and 1996 by computed tomography magnetic resonance imaging were analysed. Circadian compared using number 2-h periods with relative risk for expected average 12 intervals...
Little information is available regarding the occurrence of cerebrovascular diseases after tsunamis. This study was performed to determine influence tsunami damage caused by Great East Japan earthquake on diseases.Subjects from coastline and inland areas Iwate Prefecture who developed before disaster were included in analysis. Standardized incidence ratios 2011 against previous 3 years calculated two 4-week periods four disaster, according stroke subtype, sex, age group, flood damage.The...
Positive end-expiratory pressure (PEEP) improves respiratory conditions. However, the complex interaction between PEEP and hemodynamics in heart failure patients makes it challenging to determine appropriate settings. In this study, we developed a framework for impact of on considering cardiac function, by integrating generalized circulatory equilibrium framework, validated assessing its ability accurately predict PEEP-induced hemodynamics. eight dogs, was increased stepwise, hemodynamic...
Background: Diabetic nephropathy (DN) is a serious condition that can result in end-stage renal failure. Recent evidence has focused on the dietary effects of polyphenols blood glucose levels and complications diabetes. Objectives: In this study, we investigated protective effect glucosyl hesperidin (G-Hes), composed hesperidin, against streptozotocin (STZ)-induced mice. Methods: We used an STZ-induced diabetic mouse model to investigate preventive G-Hes pathology. After supplementation for...
Abstract Objective This study aimed to clarify the relationship between directions of humeral head translation, presence acromial or coracoid spurs, and locations tendon tears in massive rotator cuff tears. Thirty shoulders from thirty patients with who underwent reverse shoulder arthroplasty were included. Preoperative 3DCT classified translation into three groups: minimal type, posterosuperior anterosuperior type. The spurs was also assessed. MRI intraoperative findings determined torn...
PURPOSE: To evaluate secondary degeneration of the ipsilateral thalamus after cerebral infarction in middle artery (MCA) distribution by using magnetic resonance (MR) imaging. MATERIALS AND METHODS: Thirty patients (17 men, 13 women; aged 30-85 years) with embolic MCA underwent serial MR imaging 2 hours to 12 months a stroke. In 23 30 patients, authors evaluated blood flow single photon emission computed tomography (SPECT). RESULTS: T2-weighted spin-echo images disclosed hyperintense area 14...
Background —Recently, thoracic aortic stent grafting has emerged as an alternative therapeutic modality for patients with aneurysms and dissections. However, its application been limited to descending distal the arch. We report our initial clinical experience of endovascular branched graft repair arch aneurysms. Methods Results —Endovascular Inoue grafts was attempted 15 dissections under local anesthesia (n=14) or general (n=1). Single-branched were used in 14 patients, a triple-branched...
Background Myosin-induced autoimmune myocarditis of rats is a model human dilated cardiomyopathy. Resveratrol natural polyphenol found in grapes and wine that reported to have cardioprotective immunomodulatory effects. Methods Results To examine the effect resveratrol on myocarditis, vehicle or (50 mg/kg per day) was administered cardiac myosin immunized 1 day before immunization. At 14 days after immunization, had preserved function myosin-immunized according echocardiographic analysis. The...
Abstract Background and Aims Decompensated cirrhosis with fibrosis progression causes portal hypertension followed by an oedematous intestinal tract. These conditions weaken the barrier function against bacteria in tract, a condition called leaky gut, resulting invasion bacterial components. Here, we investigated role of outer‐membrane vesicles (OMVs) Escherichia coli , which is representative pathogenic gut‐derived patients pathogenesis cirrhosis. Methods We involvement OMVs humans using...