A5028133408- Gut microbiota and health
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Algal biology and biofuel production
- Seaweed-derived Bioactive Compounds
- Metabolomics and Mass Spectrometry Studies
- Microbial Metabolites in Food Biotechnology
- Genetics, Aging, and Longevity in Model Organisms
- Gout, Hyperuricemia, Uric Acid
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Infant Nutrition and Health
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Microbial Metabolic Engineering and Bioproduction
- Cytomegalovirus and herpesvirus research
- Medicinal plant effects and applications
- Nitric Oxide and Endothelin Effects
- Circular RNAs in diseases
- Food composition and properties
- Ginseng Biological Effects and Applications
- Viral Infections and Immunology Research
- Advanced Glycation End Products research
- Polysaccharides and Plant Cell Walls
State Key Laboratory of Food Science and Technology
2022-2024
Jiangnan University
2022-2024
Fujian Agriculture and Forestry University
2019-2024
Chinese People 's Liberation Army No.455 Hospital
2018-2020
A bioactive polysaccharide from microalga Chlorella pyrenoidosa (CPP) was successively prepared via DEAE-52 and G-100 columns. Nuclear magnetic resonance analysis showed that the main glycosidic bonds were composed of 1,2-linked-α-l-Fucp, 1,4-linked-α-l-Rhap, 1,4-linked-β-l-Araf, 1-linked-α-d-Glcp, 1,3-linked-β-d-GlcpA, 1,4-linked-β-d-Xylp, 1,3,6-linked-β-d-Manp. Its molecular weight 5.63 × 106 Da. The hypolipidemic effect intestinal flora regulation CPP on diet-induced rats evaluated...
<i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) play an important in ameliorating obesity but is not allowed for direct consumption most countries. To date, microbiota-directed foods selectively promote the targeted human gut microbes, providing a strategy <i>A. enhancement. Multiple studies have indicated potential regulation of polyphenol on muciniphila</i>. Therefore, screening based upregulation was performed mice. Chlorogenic acid (CGA) exhibited greater response to upregulation....
A novel polysaccharide from Ulva lactuca (ULP) was purified using a Sepharose CL-4B column. Fourier transform infrared spectroscopy, high-performance liquid chromatography, and nuclear magnetic resonance spectroscopy were employed to analyze the structure of ULP. It consisted rhamnose (Rha), glucuronic acid (GluA), galactose (Gal), xylose (Xyl) at molar ratio 32.75:22.83:1.07:6.46 with molecular weight 2.24 × 105 Da. The four major glycosidic residues found in ULP →2,3)-α-l-Rhap-(1→,...
The gut microbiome displays genetic differences among populations, and characterization of the genomic landscape in China remains limited. Here, we present Chinese Gut Microbial Reference (CGMR) set, comprising 101,060 high-quality metagenomic assembled genomes (MAGs) 3,707 nonredundant species from 3,234 fecal samples across primarily rural locations, 1,376 live isolates mainly lactic acid bacteria, 987 novel relative to worldwide databases. We observed region-specific coexisting MAGs with...
Probiotics affect intestinal metabolism and play a crucial role in gut homeostasis. Studies on probiotic effector molecules—bacteriocins, peptidoglycan, teichoic acid, exopolysaccharides, secretory proteins, short-chain fatty acids—describe their effect the barrier; immune nervous system; microbiota. However, detailed mechanism of how microbiota changes after intervention molecules remains unknown. More recently, owing to rare systematic review about function tract, it has become vital...
Grifola frondosa polysaccharide (GFP) as the natural compounds have been reported to exert diverse bioactivities. The aim of this study was investigate regulatory effects GFP on intestinal microbiota in type 2 diabetic mice. changes faeces mice upon high fat diet were determined and V3 region 16S rRNA sequenced by Illumina MiSeq high-throughput sequencing platform. Eighty operational taxonomic unit identified be shared all samples, quality richness assessed via rarefaction rank abundance...
Globally, aging and diabetes are considered prevalent threats to human health. Chlorella pyrenoidosa polysaccharide (CPP) is a natural active ingredient with multiple health benefits including antioxidant hypolipidemic activities. In this study, the aging-related diabetic (AD) mice model was established investigate underlying hypoglycemic mechanisms of CPP. It improved superoxide dismutase, catalase (CAT), glutathione peroxidase (GSH-px), malondialdehyde activities in liver insulin...
Grifola frondosa (GF), also known as maitake (a type of mushroom), has been widely used a food item and it exhibits various health-beneficial hypoglycemic activities. Rats fed with fat/high-sucrose-based diet were to determine the activity 95% 55% GF ethanol extracts (labeled GF95 GF55, respectively). The was determined by monitoring fasting blood glucose level. Oral tolerance tests conducted, levels alanine aminotransferase aspartate studied study activity. HPLC-ESI-TOF-MS technique analyze...
Enterovirus 71 (EV71) is the main cause of hand, foot and mouth disease that results in high rates severe diseases small children. Lacto-N-fucopentaose I (LNFPI) can inhibit pathogen invasion regulate intestinal flora. However, whether LNFPI inhibits EV71 infection remains unknown. In this study, we examined effect mechanism against EV71. reduced capsid protein VP1 to block virus adsorption, inhibited cyclin E transcription promoted CDK2 expression EV71-induced human rhabdomyosarcoma cells,...
Fucosylated oligosaccharides have important biological functions as well an excellent antiviral activity. A novel
Abstract The aim of this study was to explore the effects and mechanisms 95% ethanol extract Chlorella pyrenoidosa (CPE95) on lipid metabolism in hyperlipidemic rats. For sake chemical composition analysis CPE95, liquid chromatography–mass spectrometry (LC‐MS) used for determination. After treatment with serum high‐density lipoprotein cholesterol content rats increased, while contents cholesterol, triglyceride, low‐density were decreased strikingly. Moreover, result histopathology showed...