A5069945949- Spine and Intervertebral Disc Pathology
- Estrogen and related hormone effects
- Phagocytosis and Immune Regulation
- Lysosomal Storage Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Pregnancy-related medical research
- Tendon Structure and Treatment
- Influenza Virus Research Studies
- Biochemical and Molecular Research
- Cancer-related gene regulation
- Bone and Joint Diseases
- Biochemical effects in animals
- Hippo pathway signaling and YAP/TAZ
- Musculoskeletal pain and rehabilitation
Shanghai Changzheng Hospital
2024-2025
The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect development various diseases. However, relationship between reprogramming and intervertebral disc degeneration (IVDD) remains unclear. This study aims to reveal in nucleus pulposus (NPCs) during IVDD investigate mechanism glycolysis-derived lactate on NPCs. Single-cell RNA sequencing reveals IVDD, NPCs are characterized excessively elevated glycolysis, resultant causes...
Abstract Nucleus pulposus cell (NPC) senescence contributes to intervertebral disc degeneration (IVDD). However, the underlying molecular mechanisms are not fully understood. In this study, it is demonstrated that angiotensin‐converting enzyme 2 (ACE2) counteracted aging of NPCs and IVDD at cellular physiological levels. The expression ACE2 correlates negatively with degree NPC IVDD. Using both loss‐ gain‐of‐function mouse models, revealed deficiency increased exacerbated injury‐ or...