A5048408015- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- vaccines and immunoinformatics approaches
- Aquaculture disease management and microbiota
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Viral Infections and Vectors
- Metabolism, Diabetes, and Cancer
- Cancer Immunotherapy and Biomarkers
- Invertebrate Immune Response Mechanisms
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Protein Tyrosine Phosphatases
Zhongnan Hospital of Wuhan University
2023-2025
Wuhan University
2023-2025
Wuhan Institute of Virology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Central China Normal University
2019
Mitochondria play essential roles in cancer cell adaptation to hypoxia, but the underlying mechanisms remain elusive. Through mitochondrial proteomic profiling, we here find that prolyl hydroxylase EglN1 (PHD2) accumulates on mitochondria under hypoxia. substrate-binding region β2β3 loop is responsible for its translocation and contributes breast tumor growth. Furthermore, identify AMP-activated protein kinase alpha (AMPKα) as an substrate mitochondria. The EglN1-AMPKα interaction their...
Abstract Estrogen receptor α (ERα) is an important driver and therapeutic target in ∼70% of breast cancers. How ERα drives carcinogenesis not fully understood. In this study, we show that a negative regulator type I interferon (IFN) response. Activation by its natural ligand estradiol inhibits IFN-β-induced transcription downstream IFN-stimulated genes (ISGs), whereas deficiency or the stimulation with antagonist fulvestrant has opposite effects. Mechanistically, induces expression histone...
Dysregulation in protein homeostasis results accumulation of aggregates, which are sequestered into dedicated insoluble compartments so-called inclusion bodies or aggresomes, where they scavenged through different mechanisms to reduce proteotoxicity. The aggregates can be selectively by macroautophagy/autophagy called aggrephagy, is mediated the autophagic receptor SQSTM1. In this study, we have identified PLK2 as an important regulator SQSTM1-mediated aggregation polyubiquitinated proteins....
Expression of major histocompatibility complex I (MHC-I) on tumor cells is extremely important for the antitumor immune response its essential role in activating various cells, including tumor-specific CD8+ T cells. Cancers lower MHC-I expression commonly exhibit less cell infiltration and worse prognosis clinic. In this study, we conducted bioinformatic-experimental screening to identify potential gene targets enhance breast cancer (BRCA). Through a combination scoring, correlation...