A5047702479- Porphyrin and Phthalocyanine Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- Advanced Nanomaterials in Catalysis
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- RNA Interference and Gene Delivery
- MXene and MAX Phase Materials
- Nanofabrication and Lithography Techniques
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Advanced Drug Delivery Systems
- Surface Chemistry and Catalysis
- Neonatal Respiratory Health Research
- Polyoxometalates: Synthesis and Applications
- Graphene and Nanomaterials Applications
- Inhalation and Respiratory Drug Delivery
- Analytical Chemistry and Sensors
- Covalent Organic Framework Applications
National Center for Nanoscience and Technology
2023-2025
Chinese Academy of Sciences
2024-2025
University of Chinese Academy of Sciences
2024-2025
Beijing National Laboratory for Molecular Sciences
2019-2024
Peking University
2018-2024
State Key Laboratory of Rare Earth Materials Chemistry and Application
2021-2024
University of Science and Technology Beijing
2013-2023
Phototheranostics constitute an emerging cancer treatment wherein the core diagnostic and therapeutic functions are integrated into a single photosensitizer (PS). Achieving full potential of this modality requires being able to tune photosensitizing properties PS in question. Structural modification organic framework represents time-honored strategy for tuning photophysical features given system. Here we report easy-to-implement metal selection approach that allows fine-tuning excited-state...
Abstract Photodynamic therapy (PDT) is a non‐invasive treatment modality against range of cancers and nonmalignant diseases, however one must be aware the risk causing phototoxic reactions after treatment. We herein report bioinspired design next‐generation photosensitizers (PSs) that not only effectively produce ROS but undergo fast metabolism to overcome undesirable side effects. constructed series β‐pyrrolic ring‐opening seco ‐chlorins, termed beidaphyrin ( BP ), beidapholactone BPL their...
Earth-abundant metal-based theranostics, agents that integrate diagnostic and therapeutic functions within the same molecule, may hold key to development of low-cost personalized medicines. Here, we report a set O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic organonickel(II) complexes, Ni-1–4, containing strong σ-donating M–C bonds. Complexes Ni-1–4 are characterized by square-planar coordination geometry as inferred from structural studies Ni-1. They photothermal therapy,...
Sensitive and selective detection of Pb2+ is a very worthwhile endeavor in terms both human health environmental protection, as the heavy metal fairly ubiquitous highly toxic. In this study, we designed phthalocyanine-porphyrin (Pc-Por) heterodyads, namely, H2Pc-α-ZnPor (1) H2Pc-β-ZnPor (2), by connecting zinc(II) porphyrin moiety to nonperipheral (α) or peripheral (β) position metal-free phthalocyanine moiety. Upon excitation at Soret region (420 nm), dyads exhibited not only emission (605...
BODIPY-based ratiometric fluorescent probes show remarkable sensitivity under acidic conditions <italic>via</italic> a protonation-modulated ICT mechanism for monitoring lysosomal pH in living cells.
Unprecedented 3D POM-based MCFs showing good potential as anode materials in LIBs have been successfully fabricated for the first time.
Two-photon excitable fluorescent dyes with integrated functions of targeted imaging and photodynamic therapy (PDT) are highly desired for the development cancer theranostic agents. Herein, fluorescence resonance energy transfer (FRET) dyads, AceDAN-H2Por-Lyso (1a) AceDAN-ZnPor-Lyso (1b), were developed two-photon excited (TPE) lysosome-targeted PDT cells. Under one-photon or excitation, AceDAN donor can effectively state to porphyrin acceptor via high efficient FRET, leading generation...
A new general route was developed for the synthesis of polyoxometalate (POM)-based [6]catenane frameworks. The hydrothermal reaction 1,2,4-triazole and AgNO3 with saturated Keggin polyoxoanions [SiW12O40]4–/[PMo12O40]3–/[AsW12O40]3– as a template led to successful isolation POM[n]catenane members [Ag(trz)][Ag12(trz)9][HSiW12O40]·2H2O (1), [Ag(trz)][Ag12(trz)9][PMo12O40]·2H2O (2), [Ag(trz)][Ag12(trz)9][AsW12O40]·2H2O (3). Single crystal X-ray diffraction analysis not only clearly reveals...
A useful strategy for ratiometric fluorescent detecting of Ag+ is demonstrated. Upon selective binding to a BODIPY-porphyrin dyad (1), the synergistic coupling two functions, namely suppressing FRET from BODIPY donor porphyrin acceptor and fluorescence quenching acceptor, leads exceptionally large changes in intensity ratio distinct emissions (F513/F654) which allow with excellent sensitivity solution living cells.
Pulmonary delivery of anticancer therapeutics has shown encouraging performance in treating nonsmall cell lung cancer (NSCLC), which is characterized by high aggressiveness and poor prognosis. Cisplatin, a key member the family DNA alkylating agents, extensively employed during NSCLC therapy. However, development chemoresistance occurrence side effects severely impede long-term application cisplatin-based chemotherapies. Herein, we propose meaningful strategy to precisely treat...
Abstract Two‐photon excited fluorescent (TPEF) materials are highly desirable for bioimaging applications owing to their unique characteristics of deep‐tissue penetration and high spatiotemporal resolution. Herein, by connecting one, two, or three electron‐deficient zinc porphyrin units an electron‐rich triazatruxene core via ethynyl π‐bridges, conjugated multipolar molecules TAT‐(ZnP) n ( =1–3) were developed as TPEF cell imaging. The new dyes present fluorescence quantum yields (0.40–0.47)...
A C1-symmerical meso-substituted ABCD-type porphyrin, [5-phenyl-10-(2-hydroxynaphthyl)-15-(4-hydroxyphenyl)porphyrinato]zinc(II) (1), has been synthesized and characterized. The molecular structure of 1 determined by single-crystal X-ray diffraction analysis. complex crystallizes in a triclinic system with one pair enantiomeric molecules per unit cell. Resolution the racemic mixture achieved chiral HPLC techniques. In particular, absolute configurations enantiomers have assigned from NMR...
Incorporating sulfur atoms into photosensitizers (PSs) has been well-established to populate triplet states and increase singlet oxygen (
Ferromagnetic π–f exchange couplings were revealed in [RE<sup>III</sup>(Pc)(Por)]<sup>0</sup> SMMs (RE = Tb and Dy) by HF-EPR measurements.
A FRET based AceDAN–porphyrin(Zn) dyad was designed to generate red emission and singlet oxygen (<sup>1</sup>O<sub>2</sub>) simultaneously, which were utilized successfully for two-photon excited fluorescence imaging PDT of cancer cells.
Background: Currently, dozens of anabolic androgenic steroids (AAS) are forbidden in the World Anti-Doping Agency Prohibited List, however, despite extensive investigation, there still lots AAS without corresponding monoclonal antibodies. Results: A steroid analog antigen microarray made up ten was fabricated to screen hybridoma and it found an original unsuccessful clone turned out be a candidate anti-boldenone antibody, any cross-reactions with endogenous or 44 different standard reference...