A5046929411- Particle physics theoretical and experimental studies
- Advanced Electron Microscopy Techniques and Applications
- Advancements in Transdermal Drug Delivery
- Diamond and Carbon-based Materials Research
- High-Energy Particle Collisions Research
- Graphene research and applications
- Fiber-reinforced polymer composites
- Quantum Chromodynamics and Particle Interactions
- Lipid Membrane Structure and Behavior
- Carbon Nanotubes in Composites
- Crystallization and Solubility Studies
- Silicon Carbide Semiconductor Technologies
- Cellular transport and secretion
- Chronic Lymphocytic Leukemia Research
- Bone Tissue Engineering Materials
- X-ray Diffraction in Crystallography
- Evaluation Methods in Various Fields
- Bacteriophages and microbial interactions
- Computational Physics and Python Applications
- Reproductive Biology and Fertility
- Galectins and Cancer Biology
- Chemical Synthesis and Characterization
- Plant Genetic and Mutation Studies
- Radioactive element chemistry and processing
- Nanowire Synthesis and Applications
Eli Lilly (United States)
2024-2025
Loxo Oncology at Lilly (United States)
2024
Lanzhou University Second Hospital
2022
Lanzhou University
2022
Yanbian University Hospital
2022
Institute of Economics
2021
Karolinska Institutet
2008-2020
Max Planck Institute of Molecular Physiology
2012-2020
Hohhot Minzu College
2020
Henan Institute of Science and Technology
2006-2018
The skin barrier is fundamental to terrestrial life and its evolution; it upholds homeostasis protects against the environment. Skin capacity controlled by lipids that fill extracellular space of skin's surface layer--the stratum corneum. Here we report on determination molecular organization lipid matrix in situ, near-native state, using a methodological approach combining very high magnification cryo-electron microscopy (EM) vitreous section defocus series, modeling, EM simulation. are...
Amorphous silicon carbide nanosprings, as well biphase (crystalline core/amorphous sheath) helical nanowires, have been synthesized by plasma enhanced chemical vapor deposition. Both variants grow via the vapor−liquid−solid mechanism. The formation of amorphous nanosprings is explained in terms contact angle anisotropy model initially proposed to explain boron nanosprings. A modified model, where presence temperature gradients within catalyst are imposed, has nanowires. basis for this that...
Protein-tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed PTP that anchored to the endoplasmic reticulum (ER). PTP1B dephosphorylates activated receptor tyrosine kinases after endocytosis, as they transit past ER. However, also can access some plasma membrane (PM)-bound substrates at points of cell-cell contact. To explore how interacts with such substrates, we utilized quantitative cellular imaging approaches and mathematical modeling protein mobility. We find ER network comes in...
Complex living systems such as mammalian cells can be arrested in a solid phase by ultrarapid cooling. This allows for precise observation of cellular structures well cryopreservation cells. The state water, the main constituent biological samples, is crucial success cryogenic applications. Water exhibits many different states. If it cooled extremely rapidly, liquid water turns into amorphous ice, also called vitreous glassy and solid. For cryo-preservation, vitrification believed to...
TPS900 Background: Nectin-4 is a cell surface antigen overexpressed in multiple tumor types including urothelial cancer. Enfortumab vedotin (EV) first generation anti-nectin-4 antibody-drug conjugate (ADC) comprising fully humanized antibody conjugated to an MMAE payload with heterogeneous DAR 4 and approved metastatic carcinoma (mUC) both as single agent treatment refractory disease first-line combination pembrolizumab. Persistent nectin-4 expression despite progression on EV has been...
Bacterial endospores are formed by certain bacteria, such as Bacillus subtilis or the pathogenic anthracis and Clostridioides difficile, to allow survival in environmental conditions which lethal vegetative bacteria. The spores possess a particular architecture molecular inventory endow them with remarkable resistance against desiccation, heat radiation. Another spore feature is their rapid return growth during germination outgrowth. underlying processes of this latter physiological...
Autophagosome formation is a fundamental process in macroautophagy/autophagy, conserved self-eating mechanism all eukaryotes, which requires the conjugating ATG (autophagy related) protein complex, ATG12–ATG5-ATG16L1 and lipidated MAP1LC3/LC3 (microtubule associated 1 light chain 3). How complex recruited to membranes not fully understood. Here, we demonstrated that RAB33B plays key role recruiting ATG16L1 phagophores during starvation-induced autophagy. Crystal structures of bound...
In vertebrates, skin upholds homeostasis by preventing body water loss. The skin's permeability barrier is located intercellularly in the stratum corneum and consists of stacked lipid lamellae composed ceramides, cholesterol, free fatty acids. We have combined cryo-electron microscopy with molecular dynamics modeling electron simulation our analysis lamellae's formation, a maturation process beginning granulosum ending corneum. Previously, we revealed initial- end-stage organizations. this...
Increasing evidence indicates the important roles of M(3) muscarinic acetylcholine receptors (M(3) mAChR) in regulation and maintenance cardiac function heart disease. In present study, we investigated whether mAChR mediates cardioprotection against ischaemia-induced arrhythmias mechanisms involved. Myocardial ischaemia was established Wistar rats by occlusion left anterior descending coronary artery. Rats were treated with choline chloride (an agonist; 10 mg/kg, i.v.) min before occlusion....
The skin's permeability barrier consists of stacked lipid sheets splayed ceramides, cholesterol and free fatty acids, positioned intercellularly in the stratum corneum. We report here on early stage skin formation taking place inside tubuloreticular system secretory cells topmost viable epidermis intercellular space between process was analysed situ its near-native state, using cryo-EM combined with molecular dynamics modeling EM simulation. Stacks lamellae appear towards periphery they are...
Bacterial spores of the genera Bacillus and Clostridium are extremely resistant against desiccation, heat radiation involved in spread pathogenicity health relevant species such as anthracis (anthrax) or botulinum. While resistance is very well documented, underlying mechanisms not fully understood. In this study we show, by cryo-electron microscopy vitreous sections particular resin thin section electron microscopy, that dormant possess highly ordered crystalline core structures, which...
Fe 2 O 3 magnetic nanoparticles (MNPs) have been coated with silica, followed by covalent attachment of the actinide specific chelators to separate nuclear waste in acidic conditions. A general model is developed relate surface coating particle’s magnetization change, providing an alternative way characterize size-distribution/aggregation MNPs. The optimized silica protects Fe2O3 MNPs from iron leaching under highly conditions, facilitates dispersion MNPs, and dramatically increases loading...
Rapid cooling of aqueous solutions is a useful approach for two important biological applications: (I) cryopreservation cells and tissues long-term storage, (II) cryofixation ultrastructural investigations by electron cryo-electron microscopy. Usually, both approaches are very different in methodology. Here we show that novel, fast easy to use technique called self-pressurized rapid freezing (SPRF) is-after some adaptations-also versatile cryopreservation. Sealed metal tubes with high...
214 Background: In prior studies, the efficacy and safety of selpercatinib, a selective RET inhibitor, was consistent in RET+ NSCLC pts across geographies. As previously reported, LIBRETTO-431 met its primary endpoint improved PFS by blinded independent central review (BICR) at pre-planned interim analysis. Here we report from East Asia, majority study population. Methods: (NCT04194944) is randomized, open-label phase 3 trial comparing 1L selpercatinib vs control (platinum/pemetrexed +/-...
Bruton tyrosine kinase inhibitors (BTKi) have transformed the treatment of B-cell malignancies, but intolerance has often led to their discontinuation. The phase 1/2 BRUIN study evaluated pirtobrutinib, a highly selective non-covalent (reversible) BTKi, in patients with R/R malignancies (NCT03740529). Pirtobrutinib was investigated 127 at least one prior BTKi therapy absence progressive disease. most common adverse event (AE) leading discontinuation cardiac disorders (n=40, 31.5%),...