A5031900556- Adipose Tissue and Metabolism
- Gut microbiota and health
- Urticaria and Related Conditions
- Neonatal Respiratory Health Research
- Muscle Physiology and Disorders
- Neurological Disease Mechanisms and Treatments
- Autoimmune Bullous Skin Diseases
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Blood properties and coagulation
- Fibroblast Growth Factor Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antioxidants, Aging, Portulaca oleracea
- Enzyme Production and Characterization
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Stress Responses and Cortisol
- ATP Synthase and ATPases Research
- Sirtuins and Resveratrol in Medicine
- Hormonal Regulation and Hypertension
- Functional Brain Connectivity Studies
- Polysaccharides and Plant Cell Walls
China Agricultural University
2019-2024
Affiliated Hospital of Qingdao University
2019-2024
Qingdao University
2019-2024
Tianjin Medical University General Hospital
2015-2023
Hebei University
2023
Shandong Normal University
2021-2022
University at Buffalo, State University of New York
2018-2020
Sichuan Agricultural University
2019
Sarcopenia, a decrease in skeletal muscle mass and function caused by aging, impairs mobility, raises the risk of fractures, diabetes, other illnesses, severely affects senior’s quality life. Nobiletin (Nob), polymethoxyl flavonoid, has various biological effects, such as anti-diabetic, anti-atherogenic, anti-inflammatory, anti-oxidative, anti-tumor properties. In this investigation, we hypothesized that Nob potentially regulates protein homeostasis to prevent treat sarcopenia. To...
Scope Iron status is regulated via iron absorption as there no active excretion. Divalent metal‐ion transporter‐1 (DMT1) and ferroportin (FPN) are two key proteins vital for absorption, but the regulation of them in suckling mammals differs from that adults. This study aims to explore transporters under different conditions during suckling. Methods results developed rats conditions. Unexpectedly, unchanged FPN at detected. Since only known exporter mammals, limits exported into blood Thus,...
We herein report an efficient and green aerobic radical cascade reaction of o -vinylphenylisocyanides with thiols to access a broad range 2-thio-substituted quinolines without the need for additional catalysts or oxidants.
Abstract Disruption of the microbial structure intestinal bacteria due to a high‐fat diet (HFD) is closely associated with metabolic disorders, such as obesity and type 2 diabetes. Probiotics are known modulate gut microbiota; therefore, we demonstrated capability Lactobacillus paracasei N1115 ( LC ‐N1115) attenuate obesity. Four‐week‐old male C57BL/6J mice were fed HFD for 12 weeks induce then randomized supplemented placebo or LC‐ treatment group another weeks. ‐N1115 reduced weight gain...
Vascular dementia (VaD) is a progressive and highly prevalent disorder. However, in very large majority of cases, milieu cellular molecular events common for multiple neurodegenerative diseases involved. Our work focused on whether the immunomodulating effect glatiramer acetate (GA) could restore normalcy to microenvironment ameliorate cognitive decline induced by chronic cerebral hypoperfusion. We assessed function rats' performance Morris water maze (MWM), electrophysiological recordings...
Cognitive impairment is typically reflected in the time and frequency variations of electroencephalography (EEG). Integrating time-domain frequency-domain analysis methods essential to better understand assess cognitive ability. Timely identification levels early Parkinson's disease (ePD) patients can help mitigate risk future dementia. For investigation brain activity states related levels, this study recruited forty ePD for EEG microstate analysis, including 13 with mild (MCI) 27 without...
The aim of this study was to demonstrate the effect arabinoxylan on colonic mucosal barrier and metabolomic profiles in high-fat diet-induced rats. A total 20 six-week-old male rats were arranged randomly two groups (n = 10/group), including a diet (HFD) group supplemented with (AXD) group. Results showed that feeding AXD reduced serum lipopolysaccharide after 5 weeks. In digesta, Escherichia coli population reduced, while Lactobacillus, Bifidobacterium, Bacteroidetes populations increased...
Abstract Rationale The management of depression continues to be challenging despite the variety available antidepressants. Herbal medicines are used in many cultures but lack stringent testing understand their efficacy and mechanism action. Isoalantolactone (LAT) from Elecampane ( Inula helenium ) improved chronic social defeat stress (CSDS)-induced anhedonia-like phenotype mice comparable fluoxetine, a selective serotonin reuptake inhibitor (SSRI). Objectives Compare effects LAT fluoxetine...
Objectives To investigate whether dl-3-n-butylphthalide (NBP) affects cholinergic system function and ameliorates cognitive decline in a rat model of vascular dementia (VaD). Methods The VaD was established by bilateral common carotid artery ligation (two-vessel occlusion, 2VO). Rats were divided into five groups: control, sham, 2VO, 2VO+NBP (80 mg/kg; intragastric), 2VO+donepezil (1 intragastric). Treatments administered once daily for 2 weeks from day 21 post-surgery. Spatial learning...
Lung aging triggers the onset of various chronic lung diseases, with alveolar repair being a key focus for alleviating pulmonary conditions. The regeneration epithelial structures, particularly differentiation from type II (AT2) cells to I (AT1) cells, serves as prominent indicator repair. Nonetheless, precise role in impeding and its underlying mechanism remain be fully elucidated. Our study employed histological methods examine effects on structural integrity pathology. led collapse,...
BACKGROUND Gitelman syndrome (GS) is an autosomal recessive salt-losing tubulopathy characterized by renal potassium loss, hypokalemia, metabolic alkalosis, hypocalciuria, hypomagnesemia, and hyper-reninemic hyperaldosteronism. Finerenone a non-steroidal mineralocorticoid receptor antagonist that inhibits receptor-mediated sodium reabsorption decreases overactivation. This report describes 35-year-old man with mass in the right adrenal gland, diagnosis of c.1456>A heterozygous variant...
Objective Several investigations have shown that the level of fibrinogen (Fg) is associated with susceptibility to dementia and usually affected by polymorphisms in its gene. Our study aimed investigate relationship between Fg β ( FGB) −148C/T gene polymorphism patients Alzheimer’s disease (AD) vascular (VaD). Methods The included 64 AD patients, 72 VaD 56 healthy controls (HC). Plasma was detected turbidimetry. Among participants, 52 HC underwent FGB analysis using restriction fragment...
The mucilage from Brasenia schreberi (BS) exhibits various biological activities, including antialgal, antibacterial, soluble-fiber properties, and excellent lubricating behavior. Thus, the extraction wide use of in food industry are crucial. In this study, high-speed shear-assisted BS was optimized by using response surface methodology (RSM). optimal conditions were as follows: Extraction temperature 82 °C, time 113 min, liquid–solid ratio 47 mL/g, shear speed 10,000 rpm. Under these...
This paper constructs an optimal operation strategy for electricity sales company containing multiple virtual power plants (VPPs) based on Stackelberg game. The game model of and VPPs is developed to study the pricing output in market, order balance interests at same time. upper-level devotes maximizes revenue lower-level aims minimizing operating costs VPPs. As leader, dynamically adjusts purchase sale prices guide internal optimization VPPs, as followers, decides sell according price....
Modern technological lifestyles promote allergic diseases, especially food allergies. The underlying molecular mechanisms remain to be uncovered. Protein acetylation is one of the most important post-translational modifications, and it involved in regulating multiple body metabolic processes. This study aimed clarify effects a high-fat diet (HFD) on allergy risk mechanisms. Four-week-old male C57BL/6J mice were randomly divided into two groups fed normal fat (NFD) or HFD for 24 weeks. Then,...