A5101568485- Acute Kidney Injury Research
- Polysaccharides and Plant Cell Walls
- Dialysis and Renal Disease Management
- Seaweed-derived Bioactive Compounds
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Cancer-related Molecular Pathways
- Stress Responses and Cortisol
- Colorectal Cancer Treatments and Studies
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Biochemical effects in animals
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Cancer Diagnosis and Treatment
- Platelet Disorders and Treatments
- Free Radicals and Antioxidants
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
- Neurogenesis and neuroplasticity mechanisms
- interferon and immune responses
- Liver physiology and pathology
- Renal Diseases and Glomerulopathies
Shanghai Ninth People's Hospital
2011-2024
Shanghai Jiao Tong University
2011-2023
Gaochun People's Hospital
2016-2023
Nantong University
2004-2022
Affiliated Hospital of Nantong University
2022
Wenzhou Medical University
2008-2017
Southeast University
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Beijing Administration Institute
2015
Laboratoire de Génétique Médicale
2014
Transient cerebral ischemia leads to endoplasmic reticulum (ER) stress. However, the contributions of ER stress are not clear. To address this issue, activators tunicamycin (TM) and thapsigargin (TG) were administered transient middle artery occluded (tMCAO) mice oxygen-glucose deprivation-reperfusion (OGD-Rep.)-treated neurons. Both TM TG showed significant protection against ischemia-induced brain injury, as revealed by reduced infarct volume increased glucose uptake rate in ischemic...
Carnosine, a naturally occurring dipeptide, has been recently demonstrated to possess anti-tumor activity. However, its underlying mechanism is unclear. In this study, we investigated the effect and of carnosine on cell viability proliferation cultured human gastric cancer SGC-7901 cells. Carnosine treatment did not induce apoptosis or necrosis, but reduced proliferative capacity Seahorse analysis showed cells with pyruvate have active mitochondria, depend mitochondrial oxidative...
Studies have shown that miR-221 and miR-222 are deregulated in many cancers, including prostate cancer. Nevertheless, the biological role underlying mechanisms of pathogenesis androgen-independent cancer still not clear. The proliferation, apoptosis, cell cycle distinction, migration capacity cells were determined following transfection or inhibitor. impact regulation SIRT1 on investigated. MiR-221 highly expressed PC-3 compared with LNCap cells. After expression was inhibited, proliferation...
Background In addition to SARS associated coronaviruses, 4 non-SARS related human coronaviruses (HCoVs) are recognized as common respiratory pathogens. The etiology and clinical impact of HCoVs in Chinese adults with acute upper tract infection (URTI) needs be characterized systematically by molecular detection excellent sensitivity. Methodology/Principal Findings this study, we detected HCoV species real-time RT-PCR 981 nasopharyngeal swabs collected from March 2009 February 2011. All...
The role of the tumour necrosis factor-like weak inducer apoptosis (TWEAK)/Fn14 and interferon-inducible protein (IP-10)/CXCR3 axis in pathogenesis lupus nephritis were studied.The mRNA expression TWEAK, Fn14, IP-10 CXCR3 quantified glomerulus tubulointerstitium 42 patients with (LN group) 10 healthy controls.As compared to controls, LN had higher glomerular TWEAK but was lower group. Similarly, group tubulointerstitial CXCR3, than controls. Glomerular class V significantly IV nephritis....
Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA Osteoarthritis (OA) is less known. To investigate whether haplogroups contribute to prevalence knee OA, we have carried out a comprehensive case-control study on 187 OA patients and 420 geographically matched controls southern China. were classified Kellgren/Lawrence scale from two four for disease severity data analyzed by adjusting age sex. We found that with haplogroup G (OR =...
<i>Background:</i> The role of longitudinal change in sequential renal biopsies lupus nephritis (LN) patient remains elusive. <i>Methods:</i> Clinical and pathological documents 156 LN patients with repeat (412 times) were collected from a database. <i>Results:</i> percent transformation the biopsy class reference to was 75%. For that showed pure proliferative, membranous, mixed nephritis, histological pattern changed 57.8, 50.0, 60.4%, respectively. As...
Abstract Background Molecular epidemiological studies have shown that gene polymorphisms of vitamin D receptor ( VDR ) are associated with prostate cancer risks. However, previous results from many molecular remain inconsistent. Methods Blood samples were collected 122 patients and 130 age-matched control subjects in the Han population Southern China. The differences polymorphism between cases controls determined by PCR-RFLP, examiming Fok I (exon 2), Bsm I, Tru9 Apa (intron 9), Taq 9)....
Abstract Angiogenesis inhibitors are of considerable interest for treating metastatic colorectal cancer (mCRC). This trial evaluated the efficacy and safety apatinib in chemotherapy-refractory mCRC. Apatinib 500 mg was administered daily to patients who had progressed after two or more lines standard fluorouracil-based chemotherapy. Primary endpoint progression-free survival (PFS). Secondary endpoints were objective response rate (ORR), disease control (DCR), overall (OS), toxicity. Overall,...
Background Protein energy wasting (PEW) is common in patients on hemodialysis, and its development may involve gut microbial dysbiosis. However, the exact relationship between composition of different flora PEW remains unclear. Methods This an observational longitudinal study 115 undergoing hemodialysis who were followed up for 1 year. All evaluated at baseline, microbiota compositions determined. After a year follow-up period, correlations clinical parameter variations relative abundance...
Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, used mesenchymal stem cells (MSCs) as vehicles to deliver klks into the injured kidneys and measured their therapeutic effect on experimental antibody nephritis lupus Human KLK-1 (hKLK1) gene was transduced murine MSCs using retroviral vector generate stable cell line, hKLK1-MSC, expressing high levels of hKLK1. 129/svj mice subjected anti-GBM were transplanted...
Previous studies have indicated that the level of glial cell line-derived neurotrophic factor (GDNF) may be correlated with stroke and depression. Here, we investigated whether GDNF can a discriminant indicator for post depression (PSD). 159 participants were divided into four groups: PSD, without (Non-PSD), major depressive disorder (MDD) normal control (NC) group, protein mRNA expression levels in serum measured. The results showed only MDD group had statistical difference compared other...
Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age unknown. We compared epithelial isolated from young and old glands different cohorts C57BL6/J BALB/c mice, our findings revealed that were characterized by increased basal cell pool comprised mostly CD49fhi cells, altered luminal-to-basal ratio, irregular...
The prevalence of high hyperlipemia is increasing around the world. Our aims are to analyze relationship triglyceride (TG) and cholesterol (TC) with indexes liver function kidney function, develop a prediction model TG, TC in overweight people.A total 302 adult healthy subjects 273 were enrolled this study. levels fasting TG (fs-TG), (fs-TC), blood glucose, measured analyzed by correlation analysis multiple linear regression (MRL). back propagation artificial neural network (BP-ANN) was...
Post-stroke depression (PSD) is a frequent complication that worsens rehabilitation outcomes and patient quality of life. This study developed risk prediction model for PSD based on clinical socio-psychology features the early detection high patients.Risk predictors included history brain cerebral infarction (odds ratio [OR], 3.84; 95% confidence interval [CI], 2.22-6.70; P < 0.0001) four socio-psychological factors including Eysenck Personality Questionnaire with Neuroticism/Stability (OR,...