A5100644596- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Myasthenia Gravis and Thymoma
- RNA modifications and cancer
- Cancer-related gene regulation
- Transplantation: Methods and Outcomes
- Surgical Simulation and Training
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects and Assays
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Gastric Cancer Management and Outcomes
- Robotics and Sensor-Based Localization
- Lung Cancer Research Studies
- Plant Virus Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Epigenetics and DNA Methylation
- Organ Transplantation Techniques and Outcomes
- Foreign Body Medical Cases
- Radiomics and Machine Learning in Medical Imaging
First Affiliated Hospital Zhejiang University
2016-2025
Zhejiang University
2015-2024
University of Chinese Academy of Sciences
2023
Ji Hua Laboratory
2023
Yancheng Institute of Technology
2008-2021
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2010
Syracuse University
1994
The aim of this study was to construct an effective clinical nomogram for predicting the survival esophageal cancer patients after esophagectomy. We identified (n = 4,281) who underwent esophagectomy between 1988 and 2007 from Surveillance, Epidemiology, End Results (SEER) 18 registries database. Clinically significant parameters were used a based on Cox regression analyses. model validated using bootstrap resampling Chinese cohort 145). A total 4,109 SEER database included analysis....
Abstract Ricolinostat (ACY-1215), a first-in-class selective HDAC6 inhibitor, exhibits antitumor effects alone or in combination with other drugs various cancers. However, its efficacy esophageal cancer remains unclear. In this study, we found that the high expression of was associated poor prognosis squamous cell carcinoma (ESCC) tissues. Then, identified ACY-1215 significantly inhibited cellular proliferation ESCC, and caused G2/M phase arrest apoptosis. We further demonstrated treatment...
A novel detection method of small molecules, competitive immunomagnetic-proximity ligation assay (CIPLA), was developed and described in this report. Through the proximity effect caused by special probes we prepared, molecules can be detected using only one monoclonal antibody. CIPLA overcomes obstacle that (PLA) cannot used molecular detection, as two antibodies are unable to combine molecule due its structure. Two compounds, clenbuterol (CLE) ractopamine (RAC), were selected targets for...
Pulmonary sequestration (PS), a rare congenital anatomic anomaly of the lung, is usually treated through resection by conventional thoracotomy procedure. The efficacy and safety video-assisted thoracic surgery (VATS) in PS treatment has seldom been evaluated. To address this research gap, we assessed VATS large Chinese cohort.We retrospectively reviewed 58 patients with who had undergone surgical our department between January 2003 April 2014. Of these patients, 42 (72.4%) underwent...
Abstract High tumor mutation burden (TMB), which is associated with increased immunogenicity, has been identified to predict improved response immune checkpoint inhibitors (ICIs) therapy in non-small cell lung cancer (NSCLC). As host immunity also significant eliminate cells, however, its clinical impact on immunotherapy still largely unknown. Here we explored the influence of age, an important characteristic evaluate patients, TMB-based predictive system for ICIs NSCLC. Our results showed...
Surgery is an important part of multidisciplinary treatment strategy for locally advanced lung squamous cell carcinoma (LSCC), but insufficient evidence supports the feasibility and safety video assisted thoracic surgery (VATS) following neoadjuvant chemotherapy LSCC. This study aims to compare perioperative data long-term survival LSCC patients between VATS thoracotomy after chemotherapy.We retrospectively collected clinical pathological information with who underwent surgical resection...
The purpose of this study is to explore the biological mechanism Schizandrin A (SchA) inducing non-small cell lung cancer (NSCLC) apoptosis.
The prognostic performance of different lymph node staging schemes for adenocarcinoma esophagogastric junction (AEG) remains controversial. objective the present study was to compare efficacy number metastases (LNMs), positive ratio (LNR) and log odds nodes (LODDS). Patients diagnosed with Siewert type II AEG were included from Surveillance, Epidemiology, End Results database. Harrell's C-index statistic, Schemper's proportion explained variation (PEV), Akaike information criterion (AIC)...
Although significant progress has been made in the treatment of lung cancer, it remains leading cause cancer‑associated mortality. Liriopesides B (LPB) is a natural product isolated from tuber Liriope platyphylla, whose effective substances have exhibited antitumor activity several types cancer. However, functions LPB non‑small cell cancer (NSCLC) require further investigation. Therefore, present study aimed to investigate whether influences pathogenic effects NSCLC. In study, was...
We analyzed the prognostic value of N6-methyladenosine (m6A) regulatory genes in lung adenocarcinoma (LADC) and their association with tumor immunity immunotherapy response. Seventeen 20 m6A were differentially expressed LDAC tissue samples from TCGA GEO databases. developed a five-m6A gene signature based on univariate Lasso Cox regression analysis. Western blot analysis confirmed that five proteins highly LADC tissues. constructed nomogram risk AJCC stages. ROC curves calibration showed...
Lung transplantation is the only effective treatment for end-stage lung diseases. Bronchiolitis obliterans, which known as non-infectious chronic allograft dysfunction (CLAD) in new classification, greatest threat to long-term survival after transplantation. This study investigated role of leukotriene B4 (LTB4) and montelukast transplantation-related bronchiolitis obliterans discussed pathophysiological significance LTB4 rejection.Rats were randomly divided into an experimental group...
Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of ligands canonical Wnt/β-catenin signaling pathway, which contributes to carcinogenesis progression lung cell lines. The aim this study was evaluate association between EMT-related proteins (E-cadherin N-cadherin), further investigate its impact on prognosis adenocarcinoma patients. Methods: A total 147 patients were included their...
There is no consensus about whether relatively large mediastinal tumors (≥ 5.0 cm) are suitable for video-assisted thoracoscopic surgery (VATS). Therefore, this study aimed to compare the efficacy and safety of intercostal approach VATS large-sized anterior (5.0–10.0 with invasion surrounding tissues organs. A total 129 patients who received in our hospital between January 2018 July 2022 were consecutively enrolled. Patients divided into 2 groups based on tumor diameter: Group (tumor size...
The development of an indirect competitive immunomagnetic-proximity ligation assay (ICIPLA), which is a novel method for detecting small molecules, described in this report. Free molecules samples can be detected using proximity (PLA); the detection based on effect caused by high concentration molecule-BSA conjugates bound to streptavidin magnetic beads. As format immunoassay, ICIPLA has advantage that quantity monoclonal antibody (mAb) used small-molecule 8-fold lower than required (CIPLA)...