A5071809336- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- RNA Interference and Gene Delivery
- interferon and immune responses
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Musculoskeletal pain and rehabilitation
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Cervical and Thoracic Myelopathy
Cangzhou Central Hospital
2014-2023
Hospital of Hebei Province
2014
Osteosarcoma is the most common primary bone sarcoma around world. The poor prognosis and high recurrence rate of osteosarcoma are largely due to pulmonary metastasis. H19 has been reported play a potential role in progression. However, exact molecular mechanism metastasis involving remains unclear. In present study, we performed gain- loss-of-function assays found that promotes migration invasion cells. Furthermore, showed through upregulation ZEB1 ZEB2 by competitively binding miR-200...
Abstract Laminectomy is an effective surgical treatment for multi-segment cervical spondylotic myelopathy (M-CSM) but usually results in C5 palsy. Some techniques to restore the spinal sequence, increase intervertebral foramen diameter, and limit cord drift distance have been proposed; however, it unclear whether these procedures can avoid this complication. To investigate clinical efficacy of limited laminectomy foraminal decompression with fixation (LLFDF) improving neurological recovery...
Aging-related inflammation is tightly linked with the development of osteoarthritis (OA). As pro-inflammatory cytokine, IL-1β has been associated physical dysfunction and frailty. It still elusive whether how blockade improves outcome OA. Here we develop a cationic solid lipid nanoparticles (SLNs) system that effectively mediate non-viral delivery plasmid DNA (pDNA) into cells. Compared other transfer technologies including lipofetamin 2000, SLNs-pDNA less toxic exerts identical...