A5015261874- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Anatomy and Medical Technology
- Muscle Physiology and Disorders
- Hernia repair and management
- Mesenchymal stem cell research
- Micro and Nano Robotics
- Surgical Sutures and Adhesives
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Abdominal Surgery and Complications
- Bone Tissue Engineering Materials
- Reconstructive Surgery and Microvascular Techniques
- Extracellular vesicles in disease
- Wound Healing and Treatments
- Intestinal and Peritoneal Adhesions
National Tsing Hua University
2021-2025
Current materials for repairing abdominal peritoneal defects face rapid degradation, infection risk, insufficient vascular ingrowth, slow muscle regeneration, and suboptimal postoperative integration, often causing fibrotic healing hindering volumetric loss (VML) repair exceeding 30%. To address these issues, photo-cross-linkable gelatin hydrogels are combined with blood vessel-forming cells to reconstruct networks, providing temporary nutrient gas channels that support cell repair. By...
The physically-crosslinked collagen hydrogels can provide suitable microenvironments for cell-based functional vascular network formation due to their biodegradability, biocompatibility, and good diffusion properties. However, encapsulation of cells into results in extensive contraction rapid degradation hydrogels, an effect known from utilization as a pre-vascularized graft vivo. Various types chemically-crosslinked collagen-based have been successfully synthesized decrease volume...
Current treatment for complex and large-scale volumetric muscle loss (VML) injuries remains a limited success have substantial disadvantages, due to the irreversible of mass, slow regeneration, rapid formation non-functional fibrosis scars. These VML are accompanied by denervation destruction native vasculature which increases difficulties in functional restoration muscle. Here, reconstruction vascular network at injury site was offered as possible solution improving repair defects through...
Abstract Volumetric muscle loss (VML), a severe tissue from trauma or surgery, results in scarring, limited regeneration, and significant fibrosis, leading to lasting reductions mass function. A promising approach for VML recovery involves restoring vascular neural networks at the injury site, process not extensively studied yet. Collagen hydrogels have been investigated as scaffolds blood vessel formation due their biocompatibility, but reconstructing vessels guiding innervation site is...
Since the degree of severity and geometry wounds vary, it is necessary to prepare an antiadhesive hydrogel that possesses dynamically controllable material properties, exhibits biodegradability, drug-releasing properties. Injectable, oxygen peroxide-sensitive, photo-cross-linkable hydrogels permit in situ dynamic spatial control their physicochemical properties were synthesized for prevention postoperative adhesion. Albumin most abundant protein blood serum serves as a carrier several...
Tissues are much larger than the diffusion limit distance, so rapidly providing blood vessels to supply embedded cells inside tissues with sufficient nutrients and oxygen is regarded as a major strategy for success of bioengineered large thick tissue constructs. Here, patterning technique, viscous fingering, developed bioengineer vascularized-like within few minutes. By controlling viscosity, flow rate, volume photo-cross-linkable prepolymer, macro- microscale vascular network structures can...
During the process of wound healing, avoiding formation aligned collagen fibrils and subsequent scarring has become focus numerous research efforts. However, goal regeneration native or scar-free skin remains a challenge. The complex equivocal connection between inflammation within healing contributes to unsatisfactory treatment outcomes. Inspired by scarless repair observed in fetal we create two-stage combining hydrocolloid dressing attenuate immune response initial three days, biomimetic...