A5077359896- Receptor Mechanisms and Signaling
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Nitric Oxide and Endothelin Effects
- Protein Kinase Regulation and GTPase Signaling
- Renin-Angiotensin System Studies
- Nerve injury and regeneration
- Prenatal Substance Exposure Effects
- Glaucoma and retinal disorders
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Zebrafish Biomedical Research Applications
- Angiogenesis and VEGF in Cancer
- Neuroscience of respiration and sleep
Texas A&M University
2019-2025
Bryan College
2024-2025
Tulane University
2018
Purpose: This study aims to determine the impact of preconception paternal alcohol consumption (PPAC) on retinal function and morphology in PPAC-offspring. Fetal spectrum disorder (FASD)–related ocular defects caused by maternal exposure has been well investigated, but influence PPAC offspring eyes remains unknown. Methods: Adult C57BL/6J male mice were exposed either 10% ethanol or water (control) for six weeks bred naïve females. Dark-adapted light responses at two, four, months old...
Introduction Diabetic retinopathy (DR) is the leading cause of blindness among working population in USA. Current therapies, including anti-vascular endothelial growth factor treatments, cannot completely reverse visual defects induced by DR. MicroRNA-150 (miR-150) a regulator that suppresses inflammation and pathological angiogenesis. In patients with diabetes, miR-150 downregulated. As chronic major contributor to pathogenesis DR, whether diabetes-associated decrease merely associated...
Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling. As through contributes normal development, vasodilation, angiogenesis, pathogenesis of various diseases, we investigated role Lv in vasodilation developmental pathological angiogenesis this study. Methods Results The cell proliferation, migration, 3-dimensional sprouting assays were used test abilities vitro. chick...
Peptide Lv is a small endogenous secretory peptide that proangiogenic through hyperpolarizing vascular endothelial cells (ECs) by enhancing the current densities of KCa3.1 channels. However, it unclear how enhances these currents. One way to enhance ion channels promote its trafficking and insertion into plasma membrane. We hypothesized Lv-elicited augmentation occurs activating mitogen-activated protein kinase 1 (MEK1)-extracellular signal-regulated (ERK) phosphoinositide 3-kinase...
Peptide Lv is a small endogenous secretory peptide that expressed in various tissues and conserved across different species. Patients with diabetic retinopathy, an ocular disease pathological angiogenesis, have upregulated their retinas. The pro-angiogenic activity of part through promoting vascular endothelial cell (EC) proliferation, migration, sprouting, but its molecular mechanism not completely understood. This study aimed to decipher how promotes EC-dependent angiogenesis by using...
Background: Peptide Lv is an endogenous secretory peptide that upregulated in the eyes of patients with diabetic retinopathy, ocular disease pathological angiogenesis. promotes vascular endothelial cell proliferation, migration, and sprouting, blocking a specific antibody, anti-Lv, dampens neovascularization, so angiogenic factor. However, molecular mechanism how angiogenesis not clear. We found causes membrane hyperpolarization, step essential endothelium-dependent augments protein...