A5100738123- Plant and Fungal Interactions Research
- Plant Virus Research Studies
- Plant tissue culture and regeneration
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Plant Disease Resistance and Genetics
- Plant Parasitism and Resistance
- Plant Pathogens and Fungal Diseases
- Transgenic Plants and Applications
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Insect-Plant Interactions and Control
- Circular RNAs in diseases
- Fungal Biology and Applications
- Phytochemistry and Bioactive Compounds
- Plant-Microbe Interactions and Immunity
- Diabetes and associated disorders
- Plant biochemistry and biosynthesis
- Biopolymer Synthesis and Applications
- Cancer Research and Treatments
- Adenosine and Purinergic Signaling
- Chromosomal and Genetic Variations
- Antiplatelet Therapy and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
ZheJiang Academy of Agricultural Sciences
2020-2025
Shaanxi University of Chinese Medicine
2020-2021
China Pharmaceutical University
2018
Henan University
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2016
Sichuan University
2012
Pancreatic cancer patients are often resistant to chemotherapy treatment, which results in poor prognosis. The objective of this study was delineate the mechanism by miR-21 induces drug resistance 5-fluorouracil (5-FU) human pancreatic cells (PATU8988 and PANC-1). We report that PATU8988 5-FU express high levels comparison sensitive primary cells. Suppression expression 5-Fu-resistant can alleviate its resistance. Meanwhile, lentiviral vector-mediated overexpression not only conferred but...
Receptor-like kinases (RLKs) may initiate signaling pathways by perceiving and transmitting environmental signals to cellular machinery play diverse roles in plant development stress responses. The rice genome encodes more than one thousand RLKs, but only a small number have been characterized as receptors for phytohormones, polypeptides, elicitors, effectors. Here, we screened the function of 11 RLKs resistance blast fungus Magnaporthe oryzae (M. oryzae) identified negative regulator named...
Abstract The phytohormone jasmonate (JA) plays a central role in plant defenses against biotic stressors. However, our knowledge of the JA signaling pathway rice (Oryza sativa) remains incomplete. Here, we integrated multiomic data from three tissues to characterize functional modules involved organizing JA-responsive genes. In core regulatory sector, MYC2 transcription factor transcriptional cascades are conserved different species but with distinct regulators (e.g. bHLH6 rice), which genes...
Abstract Inhibition of jasmonic acid (JA) signaling renders plants more susceptible to biotic stresses. Pathogen infection can induce an increase in JA levels. However, our understanding the mechanisms mediating pathogen-induced accumulation rice (Oryza sativa) remains limited. We characterized OsLOX9, a lipoxygenase gene 13-LOX subfamily involved biosynthesis, which is induced upon by blast fungus Magnaporthe oryzae. Two independent lox9 mutants exhibited increased susceptibility M. oryzae...
Abstract Background Long non-coding RNAs (LncRNAs) have emerged as important regulators in many physiological processes plant. By high-throughput RNA-sequencing, pathogen-associated LncRNAs were mapped various plants, and some of them proved to be involved plant defense responses. The rice blast disease caused by Magnaporthe oryzae ( M. ) is one the most destructive diseases rice. However, -induced yet studied. Findings We investigated that associated with fungus. Totally 83 up-regulated...
Rice blast is one of the most serious diseases rice and a major threat to production. Breeding disease-resistant economical, safe, effective measures for control blast. As complement traditional crop breeding, transgenic method can avoid time-consuming process crosses multi-generation selection. In this study, maize ( Zea mays ) Activator Ac )/Dissociation Ds transposon vectors carrying green fluorescent protein (GFP) red (mCherry) genetic markers were used generating marker-free rice....
Long non-coding RNAs (lncRNAs) in plants are emerging as new players biotic stress responses. Pathogen-associated lncRNAs have been broadly identified and functionally characterized multiple species. However, herbivore-responsive poorly investigated. Our recent study revealed that also play roles plant defense against herbivores wild tobacco. Here, we armyworm (AW)-elicited monocot rice by employing a similar approach. A total of 238 were found to be differentially expressed (DE) AW-treated...
Abstract Numerous evidence has revealed that single-nucleotide polymorphisms (SNPs) are associated with liver cancer risk. To assess whether the MIR17HG risk in Chinese Han population, we performed a case–control (432 patients and 430 healthy controls) study. Genotyping of four variants was Agena MassARRAY platform. We used χ2 test to compare distribution SNPs allele genotypes frequencies cases controls. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated by logistic regression...
Abstract Background Long non-coding RNAs (LncRNAs) have emerged as important regulators in many physiological processes plant. By high-throughput RNA-sequencing, pathogen-associated LncRNAs were mapped various plants, and some of them proved to be involved plant defense responses. The rice blast disease caused by Magnaporthe oryzae ( M. ) is one the most destructive diseases rice. However, -induced yet studied. Findings We investigated that associated with fungus. Totally 83 up-regulated...
BACKGROUND:Traditional Chinese medicine has widely used Bolbostemma paniculatum to treat diseases, including cancer, but its underlying mechanisms remain unclear. The present study aimed elucidate the potential pharmacological of “Tu Bei Mu” (TBM), name for Bolbostemmatis Rhizoma, dry tuber B. paniculatum, treatment hepatocellular carcinoma (HCC). MATERIAL AND METHODS:The active components and putative therapeutic targets TBM were explored using SwissTargetPrediction, Traditional Medicine...
Abstract Background Long non-coding RNAs (LncRNAs) have emerged as important regulators in many physiological processes plant. By high-throughput RNA-sequencing, pathogen-associated lncRNAs were mapped various plants, and some of them proved to be involved plant defense responses. The rice blast disease caused by Magnaporthe oryzae ( M. ) is one the most destructive diseases rice. However, -induced yet studied. Findings: We investigated that associated with fungus. Totally 83 up-regulated...
Abstract Biotechnologists seeking to develop marker-free transgenic plants or multigene transformants have established different co-transformation methods. To investigate the factors affecting efficiency of T-DNA vectors via mixed Agrobacterium strains and effective strategies for selection desired co-transformants, we utilized GFP RFP as visual markers in rice tested combinations a drug-selectable vector (pGFP-HPT) non-drug selectable (pRFP) two (pGFP-HPT pRFP-HPT). Under similar...
Abstract Background Biotechnologists seeking to develop marker-free transgenic plants have established co-transformation methods. For using mixed Agrobacterium strains, the mix ratio of strains and selection scheme may influence frequency. This study used fluorescent GFP RFP markers compose different schemes for observation selective dynamics transformed rice cells investigate factors affecting efficiency.Methods ResultsWe utilized in tested combinations an antibiotic-selectable vector...