A5100463082- Dermatology and Skin Diseases
- Dermatologic Treatments and Research
- Hepatitis Viruses Studies and Epidemiology
- Protein Degradation and Inhibitors
- Antimicrobial Peptides and Activities
- Hepatitis B Virus Studies
- Atrial Fibrillation Management and Outcomes
- Collagen: Extraction and Characterization
- Psoriasis: Treatment and Pathogenesis
- Antimicrobial Resistance in Staphylococcus
- Thermoregulation and physiological responses
- Gut microbiota and health
- Facial Rejuvenation and Surgery Techniques
- Bacterial Genetics and Biotechnology
- Cancer Treatment and Pharmacology
- Hair Growth and Disorders
- Chemotherapy-related skin toxicity
- Hepatitis C virus research
- Skin Protection and Aging
- Colorectal Cancer Treatments and Studies
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
Shanghai Jiao Tong University
2024
National Institute of Allergy and Infectious Diseases
2024
National Institutes of Health
2024
University of Southern California
2021-2024
Renji Hospital
2020-2024
Southern Medical University
2022
Dalian Municipal Central Hospital
2021
Fujian Normal University
2015
Fu Wai Hospital
2014
Abstract Background The alarming spread of antimicrobial resistance requires the development novel anti-infective drugs. Despite recent research focus on human microbiome and its likely value to understand exploit inter-bacterial inhibitory phenomena as a source for strategies, microbiota has barely been investigated purpose drug development. Results We performed large screen analyzing over 3000 skin isolates evaluate bacterial competition within basis therapeutics. discovered Staphylococcus...
Abstract Diverse post-translational modifications have been shown to play important roles in regulating protein function eukaryotes. By contrast, the of bacteria are not so well understood, particularly as they relate pathogenesis. Here, we demonstrate modification by covalent addition lactate lysine residues (lactylation) human pathogen Staphylococcus aureus . Lactylation is dependent on concentration and specifically affects alpha-toxin, which a single lactylated required for full activity...
Background Horizontal neck wrinkle formation is gaining more attention among cosmetic practitioners and clients. To date, hyaluronic acid products are one of the most common treatment options for this aesthetic concern. However, different therapeutic strategies should be given to solve problem due multiple etiological reasons. Given that oxidative damage plays a critical role in formation, anti-oxidative compounds now considered by physicians when making plan. Aims evaluate efficacy safety...
Abstract The ZFX transcriptional activator binds to CpG island promoters, with a major peak at ∼200–250 bp downstream from transcription start sites. Because within the transcribed region, we investigated whether it regulates elongation. We used GRO-seq show that loss or reduction of increased Pol2 pausing ZFX-regulated promoters. To further investigate mechanisms by which transcription, determined regions protein needed for transactivation and recruitment chromatin. Interestingly, although...
Abstract This work developed a phase congruency algorithm combined with texture analysis to quantitatively characterize collagen morphology in second-harmonic generation (SHG) images from human scars. The extracted and parameters of the SHG quantified directionality, homogeneity, coarseness scars varied scar duration. Phase showed an increasing tendency mean duration, indicating that fibers are better oriented over time. Texture calculated local difference binary pattern (LD-LBP) Haar...
Docetaxel is a taxane, which class of chemotherapy agent used in the treatment multiple malignancies. It known to have gastrointestinal side effects can range from mild symptoms such as nausea and diarrhea more severe complications neutropenic enterocolitis. In current literature, taxanes not been described cause upper bleeding melena. Here, we present case 54-year-old woman with breast cancer who developed dizziness, fatigue, melena after receiving chemotherapy. Esophagogastroduodenoscopy...
ABSTRACT Hepatitis A (HAV) has emerged in outbreaks across the United States particularly at-risk populations such as men who have sex with men, well patients a history of drug use, homelessness, and incarceration. Immunization among these high-risk remains underused. In this study, we describe case acute HAV hepatitis B (HBV) coinfection an MSM patient occurring period outbreaks. Clinical resolution HBV was attained by 5 months from time initial hospitalization without viral treatment. This...