A5027594766- Cancer, Hypoxia, and Metabolism
- Streptococcal Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Bacterial Genetics and Biotechnology
- Antimicrobial Resistance in Staphylococcus
Renji Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Abstract Tumour cell metabolic plasticity is essential for tumour progression and therapeutic responses, yet the underlying mechanisms remain poorly understood. Here, we identify Prospero-related homeobox 1 (PROX1) as a crucial factor plasticity. Notably, PROX1 reduced by glucose starvation or AMP-activated protein kinase (AMPK) activation elevated in liver B1 (LKB1)-deficient tumours. Furthermore, Ser79 phosphorylation of AMPK enhances recruitment CUL4-DDB1 ubiquitin ligase to promote...
Abstract Diverse post-translational modifications have been shown to play important roles in regulating protein function eukaryotes. By contrast, the of bacteria are not so well understood, particularly as they relate pathogenesis. Here, we demonstrate modification by covalent addition lactate lysine residues (lactylation) human pathogen Staphylococcus aureus . Lactylation is dependent on concentration and specifically affects alpha-toxin, which a single lactylated required for full activity...
Abstract Pneumonia caused by community-associated Staphylococcus aureus (CA-SA) has high morbidity and mortality, but its pathogenic mechanism remains to be further investigated. Herein, we identify that staphylokinase (SAK) is significantly induced in CA-SA inhibits biofilm formation a plasminogen-dependent manner. Importantly, SAK can enhance CA-SA-mediated pneumonia both wild-type cathelicidins-related antimicrobial peptide knockout ( CRAMP −/− ) mice, suggesting exacerbates...