A5101461317- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Immunotherapy and Immune Responses
- Ocular Oncology and Treatments
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Soft tissue tumor case studies
- Coronary Artery Anomalies
- Single-cell and spatial transcriptomics
- Sulfur Compounds in Biology
- Kawasaki Disease and Coronary Complications
- Bacterial Infections and Vaccines
- Bone health and osteoporosis research
- Protein Degradation and Inhibitors
- Myasthenia Gravis and Thymoma
- Peroxisome Proliferator-Activated Receptors
- Bioactive natural compounds
- Piperaceae Chemical and Biological Studies
- Soft tissue tumors and treatment
- Transplantation: Methods and Outcomes
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
China Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Shanghai Jiao Tong University
2023-2024
Chongqing Medical University
2022-2024
Chenzhou First People's Hospital
2024
Shanghai Ninth People's Hospital
2023-2024
Shanghai Institute of Hematology
2023-2024
Second Affiliated Hospital of Zhejiang University
2022-2024
Center for Translational Molecular Medicine
2023
Chinese Institute for Brain Research
2020
Abstract Microglia are intrinsic immune cells in the central nervous system (CNS). The under controlled microglia activation plays important roles inflammatory demyelination diseases, such as multiple sclerosis (MS). However, means to modulate a therapeutic modality and underlying mechanisms remain elusive. Here we show that administration of 18β-glycyrrhetinic acid (GRA), by using both preventive treatment protocols, significantly suppresses disease severity experimental autoimmune...
Abstract Focal inflammation and remyelination failure are major hallmarks of multiple sclerosis its animal model, experimental autoimmune encephalomyelitis ( EAE ). In this study, we found that leonurine, a bioactive alkaloid, alleviated disease severity along with reduced central nervous system myelin damage. During the pathogenesis , leonurine dramatically suppressed recruitment encephalitogenic T cells into system, whereas did not impair periphery immune responses microglia activation....
Oleoylethanolamide (OEA) is an endogenous lipid mediator involved in the control of feeding, body weight, and energy metabolism. However, whether OEA modulates maturation dendritic cells (DCs) has never been addressed. Hence, we evaluated effect on DCs bone marrow-derived (BMDCs) four aspects: (a) Cell surface markers were determined using flow cytometric analysis; (b) cell mobile ability was testified with transwell assay; (c) stimulation T proliferation performed a coculture system; (d)...
Abstract Tumor-specific neoepitopes are promising targets in cancer immunotherapy. However, the identification of functional tumor-specific remains challenging. In addition to most common source, single-nucleotide variants (SNV), alternative splicing (AS) represents another rich source and can be utilized cancers with low SNVs such as uveal melanoma (UM). UM, prevalent adult ocular malignancy, has poor clinical outcomes due a lack effective therapies. Recent studies have revealed promise...
Purpose: Ocular melanoma is a common primary malignant ocular tumor in adults with limited effective treatments. Epigenetic regulation plays an important role development. The switching/sucrose nonfermentation (SWI/SNF) chromatin remodeling complex and bromodomain extraterminal domain family proteins are epigenetic regulators involved several cancers. We aimed to screen candidate small molecule inhibitor targeting these investigate its effect mechanism melanoma. Methods: observed phenotypes...
To explore the application value of syndecan-1 (SDC-1) in diagnosis coronary artery lesions (CALs) Kawasaki disease (KD) patients and correlation multiple laboratory indicators KD patients.
Abstract Current antiepileptic drugs are ineffective in one‐third of patients with epilepsy; however, identification genes involved epilepsy can enable a precision medicine approach. Here, it is demonstrated that downregulating D‐2‐hydroxyglutarate dehydrogenase ( D2HGDH ) enhances susceptibility to epilepsy. Furthermore, its potential involvement the seizure network through synaptic function modulation investigated. knockdown reduces glutathione reduced (GSH)/glutathione oxidized (GSSG)...
The aim of this study was to analyze and compare procalcitonin (PCT) levels in serum cerebrospinal fluid (CSF) as tools for detecting bacterial meningitis (BM) children. Serum CSF PCT well albumin index (AI = albumin/serum × 1000) were measured from 29 BM, 25 viral (VM), 47 non-meningitis patients. Differences between groups only significant. A stronger positive correlation level AI observed the BM patients ( R 0.68, P < .001). As a predictor area under receiver operating characteristics...
Background: Hepatic ischemia/reperfusion (I/R) injury to the liver is a significant cause of morbidity and mortality following surgery, trauma, hemorrhagic shock. It was reported that allicin, type garlic compound, had protective effect against other hepatic diseases. Allicin's ability protect caused by ischemic reperfusion remains unknown. As result, we conducted this study determine allicin's effects mechanism action in I/R injury. Method: The model established clamping blood supply left...
Children with congenital heart disease (CHD) have a predisposition to suffer from respiratory tract infections, such as bronchopneumonia (BP). In this study we investigated the characterization of lymphocyte subsets and regulatory T cells (Tregs) in these children. The frequencies were detected peripheral blood 400 children patients [100 BP only, 100 CHD (BPCHD), failure (BPHF), healthy volunteers] by using three-color flow cytometry. BPHF BPCHD groups, was analogous, lower levels CD3+,...
Purpose: Alternative splicing and isoforms diversity have been confirmed with an important decisive role in the occurrence development of tumors. Our study aimed at further exploring relationship between factors among immune subpopulations molecular signatures AS uveal melanoma. Methods: Transcriptome sequencing Nanopore Illumina RNA 15 primary melanoma patient samples was performed. PCA clustering, Cibersort analysis, HRD cluster TCR TIDE analysis were used this to evaluate correlation...
Acupoint injection has currently received increasing attention as a treatment for primary osteoporosis (POP). A number of randomized controlled trials (RCTs) have reported that acupoint some advantages in POP. However, no article summarized the existing evidence. This study will evaluate efficacy and safety clinical POP, so to provide an important reference decision-making.RCTs compared with conventional non-acupoint POP were identified searches 7 databases from their inception March 2019....
<p>Supplementary Figures and legends</p>
<p>Supplementary Figures and legends</p>
<div>Abstract<p>Tumor-specific neoepitopes are promising targets in cancer immunotherapy. However, the identification of functional tumor-specific remains challenging. In addition to most common source, single-nucleotide variants (SNV), alternative splicing (AS) represents another rich source and can be utilized cancers with low SNVs such as uveal melanoma (UM). UM, prevalent adult ocular malignancy, has poor clinical outcomes due a lack effective therapies. Recent studies have...
<div>Abstract<p>Tumor-specific neoepitopes are promising targets in cancer immunotherapy. However, the identification of functional tumor-specific remains challenging. In addition to most common source, single-nucleotide variants (SNV), alternative splicing (AS) represents another rich source and can be utilized cancers with low SNVs such as uveal melanoma (UM). UM, prevalent adult ocular malignancy, has poor clinical outcomes due a lack effective therapies. Recent studies have...
Abstract Due to the tumor immunosuppressive microenvironment and potential systemic toxicity, chemotherapy often fails trigger satisfactory anti-tumor results, so how activate immunity improve therapeutic effect remains a challenging problem. Photothermal therapy (PTT) is an efficient method of inducing neoantigen release in situ, which offers for application cancer immunotherapy. In this study, we constructed mesoporous silicon nanoparticles (MSNs) containing tetrasulfide bonds loaded with...