A5016522987- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
- Ear and Head Tumors
- DNA Repair Mechanisms
- Electromagnetic Fields and Biological Effects
- Cutaneous Melanoma Detection and Management
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Effects of Radiation Exposure
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Biofuel production and bioconversion
- Nonmelanoma Skin Cancer Studies
- CAR-T cell therapy research
- Microbial Metabolic Engineering and Bioproduction
- Inflammatory Bowel Disease
- Carcinogens and Genotoxicity Assessment
- Corneal surgery and disorders
- Ultrasound and Hyperthermia Applications
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Head and Neck Surgical Oncology
Shanghai Jiao Tong University
2021-2024
Shanghai Ninth People's Hospital
2021-2024
Shanghai Institute of Hematology
2021-2024
Taizhou Vocational and Technical College
2019
Nantong University
2014-2015
Affiliated Hospital of Nantong University
2015
Soochow University
2012-2014
University of Manitoba
2012
Human promyelocytic leukemia HL-60 cells were pre-exposed to non-ionizing 900 MHz radiofrequency fields (RF) at 12 µW/cm(2) power density for 1 hour/day 3 days and then treated with a chemotherapeutic drug, doxorubicin (DOX, 0.125 mg/L). Several end-points related toxicity, viz., viability, apoptosis, mitochondrial membrane potential (MMP), intracellular free calcium (Ca(2+)) Ca(2+)-Mg(2+) -ATPase activity measured. The results obtained in un-exposed sham-exposed control compared those...
<h3>Purpose</h3> To assess the predictive value of tumor staging system in <i>AJCC Cancer Staging Manual, Eighth Edition</i>, and histologic features for outcomes metastasis patterns conjunctival melanoma (CM). <h3>Design</h3> Retrospective, single-center cohort study. <h3>Participants</h3> Eighty-three patients with CM were treated at Shanghai Ninth People's Hospital between 2000 2021. <h3>Methods</h3> We reviewed clinical parameters used Kaplan–Meier survival curves Cox proportional...
Conjunctival melanoma (CoM) is a rare but highly lethal ocular and there limited understanding of its genetic background. To update the landscape CoM, whole-exome sequencing (WES) targeted next-generation (NGS) were performed.
Abstract The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress (RS). However, the detailed function of A3B RS not fully determined it known whether mechanism action can be exploited for therapy. Here, we conducted an immunoprecipitation-mass spectrometry (IP-MS) study...
Abstract Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for metastatic CoM, the clinical outcomes remain unfavorable. Herein, we performed single-cell RNA sequencing (scRNA-seq) of 47,017 cells obtained from normal conjunctival samples ( n = 3) and melanomas 7). Notably, noticed higher abundance cancer-associated fibroblasts (CAFs) in microenvironment (TME), correlated with enhanced angiogenic...
To determine whether mice exposed to radiofrequency fields (RF) and then injected with a radiomimetic drug, bleomycin (BLM), exhibit adaptive response provide some mechanistic evidence for such response.Adult were 900 MHz RF at 120 μW/cm(2) power density 4 hours/day 7 days. Immediately after the last exposure, sacrificed while others BLM h later. In each animal: (i) The primary DNA damage BLM-induced as well its repair kinetics determined in blood leukocytes; (ii) oxidative was from...
Abstract Retinoblastoma is a childhood retinal tumour that the most common primary malignant intraocular tumour. However, it has been challenging to identify cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing on 14,739 cells from two retinoblastoma samples delineate heterogeneity and underlying mechanism of progression. Using multiresolution network-based analysis, identified major in human retinoblastoma. Cell trajectory analysis yielded total 5...
Purpose: Retinoblastoma is the most common primary intraocular malignant tumor in children. Although intra-arterial chemotherapy and conventional have become promising therapeutic approaches for advanced retinoblastoma, side effects threaten health are unavoidable, making development of targeted therapy an urgent need. Therefore, we intended to find a potential drug human retinoblastoma by screening in-house compound library that included 89 purified well-characterized natural products....
Abstract Purpose To identify high‐risk histopathologic and molecular features of local recurrence, nodal metastasis, distant metastasis (DM) disease‐specific death (DSD) in conjunctival melanoma (CoM). Methods Ninety patients with pathologically diagnosed CoM between 2008 2023 were enrolled. Immunohistochemistry staining BRAF V600E , NRAS Q61R CD117, PD‐1 PD‐L1 was performed 65 45 patients, respectively. Cox regression Kaplan–Meier survival analysis conducted to risk factors for DM DSD....
Purpose To investigate the association of metabolism-related proteins and clinicopathological features with poor prognosis in lacrimal gland adenoid cystic carcinoma (LGACC). Methods Clinicopathological data for 39 Chinese patients LGACC enrolled were retrospectively analysed. Disease progression included death, recurrence, further nodal metastasis, distant metastasis. Expression ASCT2 GLS1 evaluated by immunohistochemistry. Kaplan–Meier survival curves Cox proportional hazards regression...
Purpose: Alternative splicing and isoforms diversity have been confirmed with an important decisive role in the occurrence development of tumors. Our study aimed at further exploring relationship between factors among immune subpopulations molecular signatures AS uveal melanoma. Methods: Transcriptome sequencing Nanopore Illumina RNA 15 primary melanoma patient samples was performed. PCA clustering, Cibersort analysis, HRD cluster TCR TIDE analysis were used this to evaluate correlation...
Abstract The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress. However, the detailed function of A3B stress not fully determined it known whether mechanism action can be exploited for therapy. Here, we conducted an immunoprecipitation-mass spectrometry (IP-MS) study...
Abstract Background Lacrimal gland adenoid cystic carcinoma is the most common lacrimal malignant epithelial tumour, characterized by high rates of relapse and distant spread. As few studies have reported pathological biomarkers for LGACC, we aimed to identify that can predict recurrence metastasis LGACC. Methods Twenty-eight patients diagnosed with LGACC between 2008 2022 were included. The level expression ASCT2, GLS1, MCT4, SHMT1 in was evaluated immunohistochemistry concordance...
Background: Systemic treatment options for distant metastatic conjunctival melanoma (CoM) has been reported in limited case series. Efficacy and safety of systemic CoM patients compared to control cases is lack.Methods: Propensity score matching (PSM) was used match cases. Regimens included immune checkpoint inhibitors (ICI), targeted therapy (TT), chemotherapy. Main outcomes overall survival (OS), time from lymph node metastasis metastasis, death; best response (BOR), disease (DC) rate;...
PGHX is a polymer of β (1-3)-galactose which posses the gel-forming property. As previously reported in flask culture experiment, crude (24.9 g/L, 48.2% yield) with maximum gel strength 957 g/cm2 can be generated. However, produced stirred bioreactor had no property when using same medium. Hence, effects different glycerol concentrations on both yield and were investigated reason for losing was explored. We proposed new strategy production enhanced formation by mediating concentration carbon...