A5058592281- RNA modifications and cancer
- Ocular Oncology and Treatments
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Nonmelanoma Skin Cancer Studies
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer and Skin Lesions
- Retinal Development and Disorders
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- interferon and immune responses
- Immunotherapy and Immune Responses
- Chromosomal and Genetic Variations
- COVID-19 Clinical Research Studies
- Carbon and Quantum Dots Applications
- Vascular Malformations and Hemangiomas
- Neurofibromatosis and Schwannoma Cases
- Infectious Diseases and Mycology
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Shanghai Institute of Hematology
2018-2025
Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, lactylation tumorigenesis remains unclear.Here, we show is elevated tumors and associated with poor prognosis ocular melanoma. Target correction aberrant triggers therapeutic efficacy both vitro vivo. Mechanistically, contributes to by facilitating YTHDF2 expression. Moreover, recognizes m6A modified PER1 TP53 mRNAs...
Targeting programmed cell death protein ligand 1 (PD-L1) remains one of the most essential immunotherapies in cancer1,2. PD-L1 has been detected nucleus multiple malignancies, playing an oncogenic role independent immune checkpoint regulation3-5. Howbeit, regulatory function nuclear (nPD-L1) to be fully understood. Here, we report that nPD-L1 is endogenous accelerator for cancer angiogenesis. First, found abundant proportion was distributed within uveal melanoma samples, which associated...
Abstract Background Dynamic N 6 -methyladenosine (m A) RNA modification generated and erased by -methyltransferases demethylases regulates gene expression, alternative splicing cell fate. Ocular melanoma, comprising uveal melanoma (UM) conjunctival (CM), is the most common primary eye tumor in adults 2nd melanoma. However, functional role of m A ocular remains unclear. Methods assays survival analysis were used to explore decreased global levels, indicating a late stage poor prognosis....
Abstract Killing the tumor cells by a visualized targeting system is promising strategy with which to achieve high efficiency, low side effects, and survival rate for therapy. Here, an autophagy regulation reported emancipating target‐functionalized carbon dots from vesicles efficient The folic acid modified N‐doped (FN‐CDs) are selectively endocytosed (specific cellular uptake >93.40%) stably existed in autophagic vacuoles cells. Next, “opened” inhibitors. Released FN‐CDs activate both...
Abstract Background Long non-coding RNAs (lncRNAs) have been identified as important epigenetic regulators that play critical roles in human cancers. However, the regulatory functions of lncRNAs tumorigenesis remains to be elucidated. Here, we aimed investigate molecular mechanisms and potential clinical application a novel lncRNA, retinoblastoma associated transcript-1 (RBAT1), tumorigenesis. Methods RBAT1 expression was determined by real-time PCR both (Rb) bladder cancer (BCa) cell lines...
Abstract Albeit N1-Methyladenosine (m1A) RNA modification represents an important regulator of metabolism, the role m1A in carcinogenesis remains enigmatic. Herein, we found that histone lactylation enhances ALKBH3 expression and simultaneously attenuates formation tumor-suppressive promyelocytic leukemia protein (PML) condensates by removing methylation SP100A, promoting malignant transformation cancers. First, is specifically upregulated high-risk ocular melanoma due to excessive levels,...
The precise temporal and spatial regulation of N5 -methylcytosine (m5 C) RNA modification plays essential roles in metabolism, is necessary for the maintenance epigenome homeostasis. Howbeit, mechanism underlying m5 C carcinogenesis remains to be fully addressed.Global mRNA levels were determined by isolation anti-m5 dot blot both retinoblastoma (RB) cells clinical samples. Orthotopic intraocular xenografts established examine oncogenic behaviours RB. Genome-wide multiomics analyses...
Uveal melanoma (UM) is an intraocular malignant tumor with a high mortality rate. Recent studies have shown the functions of long non-coding RNAs (lncRNAs) in tumorigenesis; thus, targeting tumor-specific lncRNA abnormalities has become attractive approach for developing therapeutics to treat uveal melanoma. In this study, we identified novel nuclear CANT1 (CASC15-New-Transcript 1) that acts as necessary UM suppressor. significantly reduced metastatic capacity and formation, either cell...
Purpose: This study aimed to identify a novel recombinant adeno-associated virus (rAAV) capsid variant that can widely transfect the deep retina through intravitreal injection and assess their effectiveness safety in gene delivery. Methods: By adopting sequences of various cell-penetrating peptides inserting them into modification region AAV2, we generated several variants. The green fluorescent protein (GFP)-carrying variants were screened following injection. Gene therapy experiments...
RB1 inactivation and MYCN activation have been documented as common oncogenic alterations in retinoblastoma (RB). Direct targeting of has not yet proven to be feasible. The current treatment options for RB mainly consist conventional chemotherapy, which inevitably poses health-threatening side effects. Here, we aimed screen an in-house compound library identify potential drugs the human RB. Aurora A kinase (AURKA) inhibitors were identified by differential viability screening with a tool...