A5100672930- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Ocular Oncology and Treatments
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Vascular Malformations and Hemangiomas
- Vascular Malformations Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Glaucoma and retinal disorders
- CAR-T cell therapy research
- Advanced optical system design
- Immunotherapy and Immune Responses
- COVID-19 and healthcare impacts
- Optical Wireless Communication Technologies
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Healthcare and Venom Research
- Corneal Surgery and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Vascular Tumors and Angiosarcomas
- Thyroid Disorders and Treatments
- Epigenetics and DNA Methylation
Chinese PLA General Hospital
2023-2024
Shanghai Jiao Tong University
2010-2023
Shanghai Ninth People's Hospital
2011-2023
Ruijin Hospital
2023
Yunnan University of Traditional Chinese Medicine
2023
Shanghai Institute of Hematology
2019-2022
Hunan University of Traditional Chinese Medicine
2010-2021
Renji Hospital
2020-2021
Weihai Municipal Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, lactylation tumorigenesis remains unclear.Here, we show is elevated tumors and associated with poor prognosis ocular melanoma. Target correction aberrant triggers therapeutic efficacy both vitro vivo. Mechanistically, contributes to by facilitating YTHDF2 expression. Moreover, recognizes m6A modified PER1 TP53 mRNAs...
Targeting programmed cell death protein ligand 1 (PD-L1) remains one of the most essential immunotherapies in cancer1,2. PD-L1 has been detected nucleus multiple malignancies, playing an oncogenic role independent immune checkpoint regulation3-5. Howbeit, regulatory function nuclear (nPD-L1) to be fully understood. Here, we report that nPD-L1 is endogenous accelerator for cancer angiogenesis. First, found abundant proportion was distributed within uveal melanoma samples, which associated...
The 2019 coronavirus disease (COVID-19) was first identified in Wuhan, Hubei, China December 2019, caused by a novel (SARS-CoV-2). There is need to study the clinical features of patients hospital near Wuhan.
Abstract Background Previous studies on the effects of lipotoxicity and oxidative stress islet beta cell function mainly focused patients with diabetes, whereas normal glucose tolerance (NGT) are few. The aim this study was to explore relationships among triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density (LDL-c), indicators, insulin resistance, in populations different lipid metabolism states. Methods A total 517 individuals were recruited from a rural community...
Abstract Albeit N1-Methyladenosine (m1A) RNA modification represents an important regulator of metabolism, the role m1A in carcinogenesis remains enigmatic. Herein, we found that histone lactylation enhances ALKBH3 expression and simultaneously attenuates formation tumor-suppressive promyelocytic leukemia protein (PML) condensates by removing methylation SP100A, promoting malignant transformation cancers. First, is specifically upregulated high-risk ocular melanoma due to excessive levels,...
Abstract Uveal melanoma (UM) is the most common intraocular malignant tumor in adults and has a low survival rate following metastasis; it derived from melanocytes susceptible to reactive oxygen species (ROS). Carbon dot (Cdot) nanoparticles are promising tool cancer detection therapy due their unique photophysical properties, cytotoxicity, efficient ROS productivity. However, effects of Cdots on metabolism growth not well characterized. Here, UM cell metabolomics, growth, invasiveness,...
This study aimed to evaluate the effects of exercise training on triglyceride deposition and expression musclin glucose transporter 4 (GLUT4) in a rat model insulin resistance. Thirty male Sprague-Dawley rats (8 weeks old, weight 160±10 g) were fed high-fat diet (40% calories from fat) randomly divided into control group swimming intervention group. Rats with standard food served as normal control. We found that 8-week significantly decreased body (from 516.23±46.27 455.43±32.55 visceral fat...
Long non-coding RNAs (lncRNAs) have been identified as crucial regulators in many human cancers. Many lncRNAs show aberrant expression cancer, and some of them play critical roles tumor proliferation, invasion, metastasis. However, the regulatory functions melanoma progression remain to be elucidated. We utilized Real-time PCR methodology determine LINC-PINT cell lines. To evaluate effect on tumorigenesis melanoma, we used Cell Counting Kit-8 (CCK8) colony formation assay. Flow cytometry...
Ocular melanoma, including uveal melanoma (UM) and conjunctival (CM), is the most common deadly eye cancer in adults. Both UM CM originate from melanocytes exhibit an aggressive growth pattern with high rates of metastasis mortality. The integral membrane glycoprotein beta-secretase 2 (BACE2), enzyme that cleaves amyloid precursor protein into beta peptide, has been reported to play a vital role vertebrate pigmentation metastatic melanoma. However, BACE2 ocular remains unclear. In this...
Abstract Objective To explore the therapeutic potential and underlying mechanism of metformin, an adenosine monophosphate‐activated kinase (AMPK) activator, in ocular melanoma. Methods CCK8, transwell, colony formation assays were performed to detect proliferation migration ability melanoma cells. A mouse orthotopic xenograft model was built tumor growth vivo. Western blot, immunofluorescence, electron microscopy adopted evaluate autophagy levels cells, high‐throughput proteomics CUT &...
Abstract Retinoblastoma (RB) is the most common malignant intraocular tumor of childhood. Recent studies have shown that long noncoding RNAs (lncRNAs), which are longer than 200 bp and without protein-coding ability, key regulators tumorigenesis. However, role lncRNAs in retinoblastoma remains to be elucidated. In this study, we found expression lncRNA CASC15-New-Transcript 1 ( CANT1 ) was significantly downregulated RB. Notably, overexpression inhibited RB growth both vitro vivo....