A5101600196- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Nonmelanoma Skin Cancer Studies
- Click Chemistry and Applications
- Neurological Disorders and Treatments
- Antimicrobial agents and applications
- Virtual Reality Applications and Impacts
- Cerebral Palsy and Movement Disorders
- Cancer-related gene regulation
- Nerve injury and regeneration
- Retinal Development and Disorders
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Cancer and Skin Lesions
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Sports injuries and prevention
- Myofascial pain diagnosis and treatment
- CRISPR and Genetic Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Oncology and Treatments
- Pain Management and Treatment
- Lower Extremity Biomechanics and Pathologies
- Escherichia coli research studies
- Knee injuries and reconstruction techniques
Stanford University
2021-2025
Fudan University
2025
Hunan University
2020-2024
Vision Eye Institute
2024
Sun Yat-sen University
2018-2022
Shanghai Jiao Tong University
2018-2022
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2022
Shanghai Ninth People's Hospital
2018-2022
First Affiliated Hospital of Jinan University
2020-2021
State Key Laboratory of Chemobiosensing and Chemometrics
2020
Abstract Background Dynamic N 6 -methyladenosine (m A) RNA modification generated and erased by -methyltransferases demethylases regulates gene expression, alternative splicing cell fate. Ocular melanoma, comprising uveal melanoma (UM) conjunctival (CM), is the most common primary eye tumor in adults 2nd melanoma. However, functional role of m A ocular remains unclear. Methods assays survival analysis were used to explore decreased global levels, indicating a late stage poor prognosis....
An oligoamidine with two bacteria-specific mechanisms of action showed broad-spectrum, resistance-resistant antimicrobial effect.
Purpose: This study aimed to identify a novel recombinant adeno-associated virus (rAAV) capsid variant that can widely transfect the deep retina through intravitreal injection and assess their effectiveness safety in gene delivery. Methods: By adopting sequences of various cell-penetrating peptides inserting them into modification region AAV2, we generated several variants. The green fluorescent protein (GFP)-carrying variants were screened following injection. Gene therapy experiments...
Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, the molecular mechanisms underlying neurodegeneration unknown. We find that OPTN C-terminus truncation (OPTN∆C) causes late-onset of retinal ganglion cells (RGCs), optic nerve (ON), spinal cord motor neurons, preceded by decrease axonal mitochondria in mice. discover directly interacts with both microtubules mitochondrial transport complex...
Background The use of virtual reality is popular in clinical rehabilitation, but the effects using commercial games patients with stroke have been mixed. Objective We developed a depth camera–based, task-specific game, Stomp Joy, for poststroke rehabilitation lower extremities. This study aims to assess its feasibility and efficacy. Methods carried out test Joy within representative user groups. Then, efficacy experiment was performed randomized controlled trial, which 22 received 10...
Abstract Recently, we established silicone oil-induced ocular hypertension (SOHU) mouse model with significant glaucomatous neurodegeneration. Here characterize two additional variations of this that simulate distinct glaucoma types. The first is a chronic produced by high frequency (HF) pupillary dilation after SO-induced block, which shows sustained moderate IOP elevation and corresponding slow, mild We also demonstrate although SO removal quickly returns to normal, the neurodegeneration...
Sebaceous carcinoma is a rare malignant tumour of skin. It commonly occurs in the head and neck region. The standard care for localized disease wide local excision followed by radiotherapy. Occasionally, sebaceous can be associated with Muir–Torre syndrome, which characterized lesions carcinomas visceral organs. Metastatic even rarer, very little evidence about role chemotherapy treatment metastatic disease. Here, we report case recurrent to rectum (initially mimicking rectal cancer...
Abstract Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, the molecular mechanisms underlying neurodegeneration unknown. We found that OPTN C-terminus truncation (OPTNΔC) causes late-onset of retinal ganglion cells (RGCs), optic nerve (ON), spinal cord motor neurons, preceded by striking decrease axonal mitochondria. Surprisingly, we discover directly interacts with both microtubules...
Long noncoding RNAs (lncRNAs) are an important class of pervasive RNA involved in a variety biological functions. Numerous studies have demonstrated their regulatory role human disease, especially cancer. However, the mechanism underlying transcription lncRNAs is not fully elucidated. Here, comparison local chromatin structure ROR lncRNA locus revealed cohesin-complex-mediated intrachromosomal loop that juxtaposed with upstream enhancer to promoter, enabling activation endogenous tumor...
Glutathione (GSH) has been reported to be closely related various diseases of the central nervous system, yet its authentic active ingredients and action sites remain unclear. In present study, oral exogenous GSH significantly alleviated ischemic brain injury, but this result was inconsistent with low bioavailability blood-brain barrier (BBB) permeability. To ascertain exposure GSH-derived ingredients, including GSH, cysteine (CYS), glutamate (Glu), glycine (GLY), CYS-GLY,...
Background: Cognitive frailty describes cognitive impairment associated with physical decline. Few studies have explored whether short screens identify frailty. We examined the diagnostic accuracy of Chinese versions Quick Mild Impairment (Qmci-CN) screen and Montreal Assessment (MoCA-CN) in identifying Method: Ninety-five participants symptoms (47 MCI, 34 subjective disorder 14 dementia) were included from two outpatient rehabilitation clinics. Energy (work intensity) activity levels...
Background: Screening for post-stroke cognitive impairment (PSCI) is necessary because stroke increases the incidence of and accelerates premorbid decline. The Quick Mild Cognitive Impairment (Q mci ) screen a short, reliable accurate screening instrument but not yet validated in PSCI. We compared diagnostic accuracy Chinese version Q -CN) with widely-used versions Montreal Assessment (MoCA-CN) Mini-Mental State Examination (MMSE-CN). Methods: recruited 34 patients who had recovered from...
Objectives: To investigate the effect on vascular dementia of involuntary exercise induced by functional electrical stimulation and forced voluntary exercise, focusing recovery cognitive function using a rat model dementia.Methods: A demential was created in Wistar rats who were then given allowed (wheel running) or had through stimulation. Their responses quantified Morris water maze measuring long-term potentiation hippocampus. Immunohistochemical staining used to evaluate neurogenesis...