A5085706964- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Ion channel regulation and function
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Knee injuries and reconstruction techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Orthopedic Infections and Treatments
- Analytical Chemistry and Sensors
- Virtual Reality Applications and Impacts
- Photoreceptor and optogenetics research
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Radiation Dose and Imaging
- Conducting polymers and applications
- Fuel Cells and Related Materials
- Acupuncture Treatment Research Studies
- Thyroid Cancer Diagnosis and Treatment
Sun Yat-sen University
2014-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2017-2025
Nanjing Forestry University
2025
Tianjin Stomatological Hospital
2022-2025
Washington University in St. Louis
2021-2024
South China University of Technology
2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Khon Kaen University
2023
First Hospital of Jilin University
2023
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative with high prevalence rate among the elderly population. A large number of clinical studies have suggested repetitive transcranial magnetic stimulation (rTMS) as promising non-invasive treatment for patients mild to moderate AD. However, underlying cellular and molecular mechanisms remain largely uninvestigated. In current study, we examined effect frequency rTMS on cognitive functions pathological changes in brains 4-...
Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms treatments remain elusive. Here we report therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model disease. Our findings reveal that treatment prevents memory decline 4-month-old mice motivation loss 14-month-old mice, accompanied restoration glial water channel aquaporin-4 polarity, improved brain drainage efficiency, reduction...
Major depressive disorder is one of the most common mental health conditions. Meningeal lymphatics are essential for drainage molecules in cerebrospinal fluid to peripheral immune system. Their potential role depression-like behaviour has not been investigated. Here, we show mice, sub-chronic variable stress as a model impairs meningeal females but males. Manipulations regulate sex difference susceptibility stress-induced depression- and anxiety-like behaviors well alterations medial...
Rheumatoid arthritis (RA) patients have a high prevalence for depression. On the other hand, comorbid with depression is associated worse prognosis RA. However, little known about underlying mechanisms comorbidity between RA and It remains to be elucidated which brain region critically involved in development of RA, whether alterations may affect pathological symptoms. Here, by combining clinical animal model studies, we show that patients, level significantly correlated severity disease...
Abstract Synthetic structures mimicking the transport function of natural ion channel proteins have a wide range applications, including therapeutic treatments, separation membranes, sensing, and biotechnologies. However, development polymer‐based artificial channels has been hampered due to limitation on available models. In this study, we demonstrate great potential bottlebrush polymers as accessible versatile molecular scaffolds for developing efficient channels. Adopting configuration...
Background The use of virtual reality is popular in clinical rehabilitation, but the effects using commercial games patients with stroke have been mixed. Objective We developed a depth camera–based, task-specific game, Stomp Joy, for poststroke rehabilitation lower extremities. This study aims to assess its feasibility and efficacy. Methods carried out test Joy within representative user groups. Then, efficacy experiment was performed randomized controlled trial, which 22 received 10...
Prunus xueluoensis, a unique germplasm resource native to China, exhibits significant ornamental value due its short juvenile phase, early flowering period, abundant flowers, and elegant tree form. However, the lack of an efficient regeneration genetic transformation system has hindered improvement wider application. In this study, we focused on optimizing tissue culture conditions for P. xueluoensis establishing Agrobacterium-mediated transient system. We first determined optimal medium...
Functional electrical stimulation (FES) may induce involuntary exercise and make beneficial effects on vascular dementia (VD) by strengthening the BDNF-pCREB-mediated pathway hippocampal plasticity. Whether FES improves recognition memory synaptic plasticity in prefrontal cortex (PFC) was investigated establishing a VD model.The rats were administered with two weeks of voluntary exercise, forced or induced FES. Sham-operated control groups also included. The behavioral changes assessed novel...
Abstract Background Osteosarcoma represents a serious clinical challenge due to its widespread genomic alterations, tendency for drug resistance and distant metastasis. New treatment methods are urgently needed address those difficulties in osteosarcoma improve patient prognoses. In recent years, small-molecule based anion transporter have emerged as innovative promising therapeutic compound with various biomedical applications. However, lack of efficient delivery methods, using ion...
Objectives:Forced and voluntary exercises are known to improve cognition induce neuroprotection after stroke, however, any effects of involuntary movement induced by functional electrical stimulation (FES) unclear. The exercise FES, forced on the recovery cognitive function in vascular dementia regional repair ischaemic lesions were investigated using a rat model.Methods:Wistar rats randomly assigned sham group, control group (VD), an (I-Ex), (F-Ex) or (V-Ex). An object recognition test...
Knee osteoarthritis (OA) is a prevalent disabling disorder that involves changes in articular cartilage damage, subchondral bone remodeling, synovitis, and abnormal infrapatellar fat pad (IPFP). Due to the complicated etiology numerous phenotypes of knee OA, limited improvement achieved for treatments among OA patients with different phenotypes. Inflammatory phenotype typical phenotype, individualized treatment targeting inflammation promising way obtain an optimal therapeutic effect people...
Background: Cognitive frailty describes cognitive impairment associated with physical decline. Few studies have explored whether short screens identify frailty. We examined the diagnostic accuracy of Chinese versions Quick Mild Impairment (Qmci-CN) screen and Montreal Assessment (MoCA-CN) in identifying Method: Ninety-five participants symptoms (47 MCI, 34 subjective disorder 14 dementia) were included from two outpatient rehabilitation clinics. Energy (work intensity) activity levels...