A5047910404- Nanopore and Nanochannel Transport Studies
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Virus-based gene therapy research
- Membrane Separation Technologies
- Supramolecular Self-Assembly in Materials
- Neuropeptides and Animal Physiology
- Fuel Cells and Related Materials
- Pain Mechanisms and Treatments
- Veterinary Pharmacology and Anesthesia
- Membrane-based Ion Separation Techniques
- Membrane Separation and Gas Transport
- Analytical Chemistry and Sensors
- Advanced Polymer Synthesis and Characterization
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- Organoselenium and organotellurium chemistry
- Herpesvirus Infections and Treatments
- Ion channel regulation and function
- Poxvirus research and outbreaks
- Hydrogels: synthesis, properties, applications
- Adversarial Robustness in Machine Learning
- Turtle Biology and Conservation
- Prenatal Substance Exposure Effects
- Organic Light-Emitting Diodes Research
South China University of Technology
2021-2024
Pennsylvania State University
2001-2023
State Key Laboratory of Supramolecular Structure and Materials
2014-2022
Jilin University
2014-2022
Beihang University
2017-2021
Union Hospital
2021
Cloud Computing Center
2021
Weatherford College
2018-2019
Park University
2018-2019
Jilin Medical University
2014-2017
Synthetic polymer membranes, critical to diverse energy-efficient separations, are subject permeability-selectivity trade-offs that decrease their overall efficacy. These due structural variations (e.g., broad pore size distributions) in both nonporous membranes used for Angstrom-scale separations and porous nano micron-scale separations. Biological utilize well-defined pores provide exceptional transport properties can be as inspiration overcome this trade-off. Here, we present a...
Membrane channels span the cellular lipid bilayers to transport ions and molecules into cells with sophisticated properties including high efficiency selectivity. It is of particular biological importance in developing biomimetic transmembrane unique functions by means chemically synthetic strategies. An artificial unimolecular channel using pore-containing helical macromolecules reported. The self-folding, shape-persistent, are able bilayer, thus result extraordinary stability transporting...
SUMMARY The effect of shipping stress on immunologic functions was examined in mice. mice were shipped either by truck or plane, 2 the most common modes for transport animals. While transit, temperature fluctuations and light intensity monitored. foot pad test, hemagglutination assay, plaque-forming cell assay used to measure function. Corticosterone concentrations quantitated with a competitive proteinbinding technique. Regardless method shipment, corticosterone values markedly increased at...
Potassium ion channels specifically transport K+ ions over Na+ across a cell membrane. A queue of four binding sites in the channel pore plays significant roles during highly selective conduction. kind aromatic helical oligomer was synthesized that can selectively bind . By stacking oligomers, type artificial with contiguous constructed. Such exhibited exceptionally high /Na+ selectivity ratios transmembrane
Self-healing, one of the exciting properties materials, is frequently used to repair damage biological and artificial systems. Here we have enzymatic catalysis approaches develop a fast self-healing hydrogel, which has been constructed by dynamic aldimine cross-linking pillar[5]arene-derivant dialdehyde-functionalized PEG followed encapsulation glucose oxidase (GOx) catalase (CAT). In specific, two hydroxyl groups at terminal PEG4000 are functionalized with benzaldehydes that can interact...
Abstract Synthetic structures mimicking the transport function of natural ion channel proteins have a wide range applications, including therapeutic treatments, separation membranes, sensing, and biotechnologies. However, development polymer‐based artificial channels has been hampered due to limitation on available models. In this study, we demonstrate great potential bottlebrush polymers as accessible versatile molecular scaffolds for developing efficient channels. Adopting configuration...
Cell membranes control mass, energy, and information flow to from the cell. In cell membrane a lipid bilayer serves as barrier layer, with highly efficient molecular machines, proteins, serving transport elements. this way, specialized properties are achieved by these composite materials segregating matrix function using different components. For example, containing aquaporin proteins can ∼4 billion water molecules per second while rejecting all other including salts, feat unmatched any...
Due to their distinctive molecular architecture, ABA triblock copolymers will undergo specific self-assembly processes into various nanostructures upon introduction a B-block selective solvent. Although much of the focus in copolymer has been on equilibrium nanostructures, little attention paid guiding principles nanostructure formation during non-equilibrium processing conditions. Here we report universal and quantitative method for fabricating controlling hierarchical structures using...
Aquaporins (AQPs) are naturally occurring water channel proteins. They can facilitate molecule translocation across cellular membranes with exceptional selectivity and high permeability that unmatched in synthetic membrane systems. These unique properties of AQPs have led to their use as functional elements recent years. However, the intricate nature concerns regarding stability processability encouraged researchers develop channels mimic structure other biological water-conducting channels....
The spontaneous alignment of molecular dipoles that occurs in many organic light-emitting diodes (OLEDs) is known to blunt their performance, but not easy control within a given device stack. This study shows coevaporating small amount polyethylene the electron-transport layer an OLED dramatically reduces orientational polarization, leading increased efficiency and lifetime due decreased exciton-polaron annihilation emissive layer. result highlights potential semiconductor dilution improve...
Ulcers and erosions of the corneal epithelium, as well delays in resurfacing cornea after wounding, are major causes ocular morbidity visual loss diabetes. To study whether intervention by opioid antagonist naltrexone (NTX; 30 mg/kg, twice daily) can restore reepithelialization diabetic cornea, we induced diabetes rats intravenous injection 65 mg/kg streptozotocin. After confirmation diabetes, 5-mm-diameter epithelial defects that did not include limbus were created mechanical scraping...
Bambus[6]uril analogs are excellent anion binders but only the sulfur analog is also an effective transporter capable of polarizing lipid membranes through selective uniport.
Abstract Potassium ion channels specifically transport K + ions over Na across a cell membrane. A queue of four binding sites in the channel pore plays significant roles during highly selective conduction. kind aromatic helical oligomer was synthesized that can selectively bind . By stacking oligomers, type artificial with contiguous constructed. Such exhibited exceptionally high /Na selectivity ratios transmembrane
Abstract Background Osteosarcoma represents a serious clinical challenge due to its widespread genomic alterations, tendency for drug resistance and distant metastasis. New treatment methods are urgently needed address those difficulties in osteosarcoma improve patient prognoses. In recent years, small-molecule based anion transporter have emerged as innovative promising therapeutic compound with various biomedical applications. However, lack of efficient delivery methods, using ion...
Background: Chronically implanted catheters often become covered with a thin, white adherent covering of tissue that has been referred to as fibrin sheath. This interferes catheter function. Methods: To chronicle the development this sheath, rats were silicone rubber central venous catheters. Five euthanized at 3, 7, and 60 days postimplantation so gross necropsy histology could be performed on catheterized vessels. Results: The coating developed around external portion started dark red...