A5077038775- Nanopore and Nanochannel Transport Studies
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Minerals Flotation and Separation Techniques
- Enzyme Catalysis and Immobilization
- Catalysis for Biomass Conversion
- Process Optimization and Integration
- Lipid Membrane Structure and Behavior
- Fuel Cells and Related Materials
- Catalysis and Hydrodesulfurization Studies
- Membrane Separation Technologies
- Advanced Polymer Synthesis and Characterization
- Electrochemical sensors and biosensors
- Enzyme Production and Characterization
- Photosynthetic Processes and Mechanisms
- Membrane Separation and Gas Transport
- Block Copolymer Self-Assembly
- Lignin and Wood Chemistry
- Catalysts for Methane Reforming
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Chemistry and Chemical Engineering
- Diatoms and Algae Research
- Pickering emulsions and particle stabilization
- Advanced biosensing and bioanalysis techniques
National Renewable Energy Laboratory
2018-2024
Pennsylvania State University
2013-2018
Park University
2016
Significance This study focuses on the design of highly permeable artificial water channels for use in membrane-based separation materials. A platform was developed systematic characterization single-channel conduction channels, which is based permeability measurement by stopped-flow light-scattering experiments and single-molecule counting fluorescence correlation spectroscopy. With this redesigned peptide-appended pillar[5]arene found to be similar that aquaporins, natural channel...
Synthetic polymer membranes, critical to diverse energy-efficient separations, are subject permeability-selectivity trade-offs that decrease their overall efficacy. These due structural variations (e.g., broad pore size distributions) in both nonporous membranes used for Angstrom-scale separations and porous nano micron-scale separations. Biological utilize well-defined pores provide exceptional transport properties can be as inspiration overcome this trade-off. Here, we present a...
The economics of chemical and biological processes is often dominated by the expense downstream product separations from dilute streams.
Our review focuses on biomimetic and bioinspired ideas to improve enzyme-driven bioelectrochemical systems for applications in energy, biomedical environmental fields.
Carboxylic acids are common products produced from the bioconversion of renewable feedstocks. In these processes separation acid product fermentation broth is most energy and cost intensive unit operation. Thus, development robust, scalable approaches that can be applied to a variety carboxylates critical importance utilize carboxylic as platform chemicals. Here we report batch method includes cell particulate removal, cation exchange, activated carbon treatment, dewatering with polymer...
The production of fuels from lignocellulosic biomass is key to reduce our reliance on petroleum and promote a sustainable bioeconomy. Butyric acid (BA) promising chemical precursor for the renewable diesel jet fuels. BA can be biologically produced sugars. However, challenges associated with product selectivity recovery must overcome achieve industrially relevant metrics. Here, we evaluate various fermentation configurations demonstrate near-homo-butyrate by using biocatalyst Clostridium...
Lignin is an abundant renewable resource that a promising substrate for upgrading to fuels and chemicals.
Two-dimensional photosynthetic protein crystals provide a high density of aligned reaction centers. We reconstitute the robust light harvesting Photosystem I into 2D crystal with lipids and integrate photo-electrochemical device. A 4-fold photocurrent enhancement is measured by incorporating conjugated oligoelectrolytes to form supporting conductive bilayer in device which produces ∼600 μA per mg PSI deposited. As service our authors readers, this journal provides information supplied...
Two-dimensional (2D) alignment and crystallization of membrane proteins (MPs) is increasingly important in characterizing their three-dimensional (3D) structure, designing pharmacological agents, leveraging MPs for biomimetic devices. Large, highly ordered MP 2D crystals block copolymer (BCP) matrices are challenging to fabricate, but a facile scalable technique aligning crystallizing thin-film geometries would rapidly translate into applications. This work introduces novel method grow...
Membrane protein and membrane protein-mimic functionalized materials are rapidly gaining interest across a wide range of applications, including drug screening, DNA sequencing, delivery, sensors, water desalination, bioelectronics. In these material performance is highly dependent on activity-per-protein packing density in bilayer bilayer-like structures collectively known as biomimetic membranes. However, clear understanding of, accurate tools to study properties membranes does not exist....
Block copolymer membranes stabilize photosystem I in a long-lasting, high performance photocurrent generating device.
Recent works have established bio-based carboxylic acids as adaptable precursors to renewable biofuels and chemicals.
We examine the kinetics of polymer chain exchange between mixed block copolymer–detergent micelles, a system relevant to synthesis protein-containing biomimetic membranes. While copolymer (BCP) aggregates in water is too slow observe, and detergent molecules micelles on time scale nanoseconds microseconds, BCP chains detergent–polymer intermediate scales many minutes few days. membrane-protein-relevant, vesicle-forming, ultrashort polymer, poly(ethyl ethylene)20-poly(ethylene oxide)18...
A membrane-based emulsion separator can enable continuous solvent extraction in bioprocessing separations with substantially improved demulsification and mass transfer rates, including where formation is a challenge.
A simple, low energy, and productive filtration method to clarify biomass hydrolysate enable biochemical thermochemical pathways biofuels biochemicals.
A downstream process was developed for producing pure monopotassium glucarate and crystalline glucaric acid from a fermentation broth.
<italic>In situ</italic> product recovery (ISPR) of bio-based chemicals from microbial cultivation is a means to improve titer, rate, and yield because it alleviates end inhibition.