A5008247931- Lipid Membrane Structure and Behavior
- Photosynthetic Processes and Mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Endoplasmic Reticulum Stress and Disease
- Spectroscopy and Quantum Chemical Studies
- Advanced Electron Microscopy Techniques and Applications
- Advanced Wireless Communication Techniques
- ATP Synthase and ATPases Research
- Ion Transport and Channel Regulation
- Surfactants and Colloidal Systems
- Enzyme Structure and Function
- Ubiquitin and proteasome pathways
- Energy Efficient Wireless Sensor Networks
- Wireless Communication Networks Research
- Electron and X-Ray Spectroscopy Techniques
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Protein Structure and Dynamics
- Indoor and Outdoor Localization Technologies
- Nerve injury and regeneration
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- PAPR reduction in OFDM
- Blood groups and transfusion
Arizona State University
2017-2025
Harvard University
2013-2024
Biogen (United States)
2024
Heidelberg Institute for Theoretical Studies
2024
Rockefeller University
2024
Tempe Union High School District
2020
Industrial Technology Research Institute
2006-2014
University of California, Davis
2006-2014
Ming Chuan University
2012
ITRI International
2009-2011
We observe previously unknown interactions between clinically important adenovirus vector capsids, platelet factor 4, and CAR.
In this letter, we develop a robust and scalable algorithm to cope with the sensor placement problem for target location under constraints of cost limitation complete coverage. The is NP-complete arbitrary fields. grid-based scenario adopted formulated as combinatorial optimization minimizing maximum distance error in field constraints. proposed based on simulated annealing approach. experimental results reveal that, small fields, can find optimal minimum limitation. Moreover, it also large fields
Nanoparticles are of wide interest due to their potential use for diverse commercial applications. Quantum dots (QDs) semiconductor nanocrystals possessing unique optical and electrical properties. Although QDs commonly made cadmium, a metal known have neurological effects, transport directly the brain has not been assessed. This study evaluated whether (CdSe/ZnS nanocrystals) could be transported from olfactory tract via inhalation. Adult C57BL/6 mice were exposed an aerosol 1 h nasal...
In this letter, we develop a robust and scalable algorithm to cope with the sensor placement problem for target location under constraints of cost limitation complete coverage. The is NP-complete arbitrary fields. grid-based scenario adopted formulated as combinatorial optimization minimizing maximum distance error in field constraints. proposed based on simulated annealing approach. experimental results reveal that, small fields, can find optimal minimum limitation. Moreover, it also large fields
Cyclic nucleotide-modulated ion channels are important for signal transduction and pacemaking in eukaryotes. The molecular determinants of ligand gating these still unknown, mainly because a lack direct structural information. Here we report ligand-induced conformational changes full-length MloK1, cyclic potassium channel from the bacterium Mesorhizobium loti, analysed by electron crystallography atomic force microscopy. Upon cAMP binding, nucleotide-binding domains move vertically towards...
In higher plants, chloroplast ATP synthase has a unique redox switch on its γ subunit that modulates enzyme activity to limit hydrolysis at night. To understand the molecular details of modulation, we used single-particle cryo-EM determine structures spinach in both reduced and oxidized states. The disulfide linkage introduces torsional constraint stabilize two β hairpin structures. Once reduced, free cysteines alleviate this constraint, resulting concerted motion complex smooth transition...
Visualizing the structure of protein-inorganic interface is critically important for a more complete understanding biomineralization. Unfortunately, there are limited approaches direct and detailed study biomolecules that interact with inorganic materials. Here, we use single-particle cryo-electron microscopy (cryo-EM) to protein-nanoparticle (NP) interactions human light chain ferritin visualize high-resolution details interface. In this work, determined 2.85 Å bound its native iron oxide...
We use direct imaging and dynamic light scattering to reveal the previously unknown self-assembly of detonation nanodiamond dispersions in water which have been purified without additional surface modification.
Two-dimensional (2D) alignment and crystallization of membrane proteins (MPs) is increasingly important in characterizing their three-dimensional (3D) structure, designing pharmacological agents, leveraging MPs for biomimetic devices. Large, highly ordered MP 2D crystals block copolymer (BCP) matrices are challenging to fabricate, but a facile scalable technique aligning crystallizing thin-film geometries would rapidly translate into applications. This work introduces novel method grow...
This paper presents a modified interpolation-based QR decomposition algorithm for the grouped-ordering multiple input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems. Based on original research that integrates calculations of frequency-domain channel estimation and MIMO-OFDM system, this study proposes possesses scalable property to save power consumption in variable-rank MIMO scheme. Furthermore, we also develop general equations timing scheduling method...
In this paper, we develop an algorithm to cope with the sensor placement problem for target location under constraints of cost limitation and complete coverage. We adopt grid-based scenario that deploys exact one in grid point at most. A a can be positioned by set sensors whose transmission radius covers point. The optimal is find deployment such targets any fields. However, due limitation, cannot achieved frequently. Consequently, positioning accuracy major issue problem. distance error...
Abstract The photochemical reaction center (RC) features a dimeric architecture for charge separation across the membrane. In green sulfur bacteria (GSB), trimeric Fenna-Matthews-Olson (FMO) complex mediates transfer of light energy from chlorosome antenna to RC. Here we determine structure photosynthetic supercomplex GSB Chlorobaculum tepidum using single-particle cryogenic electron microscopy (cryo-EM) and identify cytochrome c subunit (PscC), two accessory protein subunits (PscE PscF),...
Aquaporin-0 (AQP0) tetramers form square arrays in lens membranes through a yet unknown mechanism, but are enriched sphingomyelin and cholesterol. Here, we determined electron crystallographic structures of AQP0 sphingomyelin/cholesterol performed molecular dynamics (MD) simulations to establish that the observed cholesterol positions represent those seen around an isolated tetramer largely defines location orientation most its associated molecules. At high concentration, increases...
3′ Untranslated regions (3′ UTRs) of mRNAs emerged as central regulators cellular function because they contain important but poorly characterized cis -regulatory elements targeted by a multitude regulatory factors. The model nematode Caenorhabditis elegans is ideal to study these interactions it possesses well-defined UTRome. To improve its annotation, we have used genome-wide bioinformatics approach download raw transcriptome data for 1088 sets corresponding the entire collection C....