A5067739951- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Endoplasmic Reticulum Stress and Disease
- Nerve injury and regeneration
- Retinal Diseases and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
Stanford University
2022-2025
Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, the molecular mechanisms underlying neurodegeneration unknown. We find that OPTN C-terminus truncation (OPTN∆C) causes late-onset of retinal ganglion cells (RGCs), optic nerve (ON), spinal cord motor neurons, preceded by decrease axonal mitochondria in mice. discover directly interacts with both microtubules mitochondrial transport complex...
Retinal ganglion cells (RGCs) are heterogeneous projection neurons that convey distinct visual features from the retina to brain. Here, we present a high-throughput in vivo RGC activity assay response light stimulation using noninvasive Ca 2+ imaging of thousands RGCs simultaneously living mice. Population and single-cell analyses longitudinal reveal functional responses unprecedented individual conversions during traumatic glaucomatous degeneration. This study establishes foundation for...
Previously, we developed a simple procedure of intracameral injection silicone oil (SO) into mouse eyes and established the SOHU (SO-induced ocular hypertension under-detected) glaucoma model with reversible intraocular pressure (IOP) elevation significant glaucomatous neurodegeneration. Because anatomy non-human primate (NHP) visual system closely resembles that humans, it is most likely to predict human responses diseases therapies. Here tried replicate in rhesus macaque monkeys. All six...
ABSTRACT Neurons use cell-adhesion molecules (CAMs) to interact with other neurons and the extracellular environment: combination of CAMs specifies migration patterns, neuronal morphologies, synaptic connections across diverse neuron types. Yet little is known regarding intracellular signaling cascade mediating CAM recognitions at cell surface different In this study, we investigated neural developmental role Afadin 1–4 , a cytosolic adapter protein that connects multiple families F-actin....