A5053837840- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Bone Tissue Engineering Materials
- Cellular and Composite Structures
- Additive Manufacturing Materials and Processes
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- TGF-β signaling in diseases
- Additive Manufacturing and 3D Printing Technologies
- Nerve injury and regeneration
- Reconstructive Surgery and Microvascular Techniques
- Shoulder Injury and Treatment
- Pressure Ulcer Prevention and Management
- Graphene and Nanomaterials Applications
- Aortic Disease and Treatment Approaches
- biodegradable polymer synthesis and properties
- Antimicrobial agents and applications
- Bone health and treatments
- Tendon Structure and Treatment
- Spinal Cord Injury Research
- Sports injuries and prevention
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
Shanghai Sixth People's Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Wound healing is a process that requires angiogenesis and antibacterial activities it remains challenge for both experimental clinical research worldwide. Zn2+ has been reported to be widely involved in exerts effects, making suitable as treatment promote wound healing. Therefore Zn2+-loaded adhesive bacterial cellulose hydrogel was designed observe its angiogenic abilities the process.The characterization, tensile strength, swelling behaviors activity of cellulose/polydopamine/zeolitic...
Mechanical performance is crucial for lattice structures used in orthopedic applications because they should simultaneously possess high strength and porosity. Although the additively manufactured Ti-6Al-4 V functionally graded porous structure (FGPS) has proven to be most promising material owing its good mechanical performance, impact of porosity gradient pattern on their scarcely been investigated. In this study, FGPSs with varied same overall were designed by triply periodic minimal...
Osteogenesis, osteoclastogenesis, and angiogenesis play crucial roles in bone regeneration. Parathyroid hormone (PTH), an FDA-approved drug with pro-osteogenic, pro-osteoclastogenic proangiogenic capabilities, has been employed for clinical osteoporosis treatment through systemic intermittent administration. However, the successful application of PTH local defect repair generally requires incorporation delivery by appropriate carriers. Though several scaffolds have developed to deliver PTH,...
Wound healing and angiogenesis remain challenges for both clinical experimental research worldwide. Periosteum-derived extracellular vesicles (P-sEVs) delivered by hydrogel dressings provide a potential strategy wound defects to promote fast healing. In this study, we designed NAGA/GelMA/Laponite/glycerol dressing that can release P-sEVs accelerate (named P-sEVs@hydrogel) (
Traumatic spinal cord injury (SCI) is a major clinical challenge, imposing significant burden on both patients and healthcare systems. The complexity of SCI stems from its multifactorial pathogenesis, incorporating variety regulating factors. Despite the exploration mechanisms pathophysiology development biomedical therapies, current interventions are still limited to surgical rehabilitative care. This study introduces an approach protect mitochondria-a pivotal factor in pathogenesis-through...
The amelioration of refractory diabetic ulcers presents a formidable conundrum on global scale, attributable to the elevated peril contagion and protracted convalescence durations. Within purlieus this reparative epoch, deployment efficacious wound coverings endowed with both angiogenesis antibacterial attributes is paramount significance. Hydrogel dressings are distinguished by their biocompatibility, adhesive tenacity, innate regenerative capacity. Eugenol, substance distilled from...
Although various dressings currently used have the effect of promoting wound healing, they still cannot meet requirements clinically efficient treatment. Recently, parathyroid hormone (PTH) and its pathway been shown as new target for repair. However, using PTH in clinical treatment can be a question. This study is to develop novel PTHrP-2 loaded cellulose acetate nanofiber mat (CAP) via electrospinning benefit By observing effects prepared CAP on cell proliferation, migration, tube...
Retraction and degenerative changes of chronic rotator cuff tears limit the healing capacity after routine surgical repair.To fabricate a mesenchymal stem cell-derived exosome (MSC-Exos) loaded patch evaluate effect this on activity rabbit tenocytes in vitro repair associated with vivo.Controlled laboratory study.The MSC-Exos was fabricated using dynamic wet-spinning system. In studies, proliferation migration activities were evaluated by culturing saline, fiber-aligned patch, or an patch....
Hydrogels have become an attractive option for tissue repair. A novel multifunctional hydrogel was developed using a two-step method involving photopolymerization and tannic acid (TA) solution incubation. The mechanical properties of this were enhanced by the multi-hydrogen bond interaction between TA N-acryloyl glycinamide/gelatin methacrylate (NAGA/GelMA). compressive modulus doubled. strengths 5.5 MPa. swelling rate reduced factor three. adhesion strength composite reached 80 KPa....
Osteogenesis, osteoclastogenesis, and angiogenesis play crucial roles in bone regeneration. Parathyroid hormone (PTH), an FDA-approved drug with pro-osteogenic, pro-osteoclastogenic proangiogenic capabilities, has been employed for clinical osteoporosis treatment through systemic intermittent administration. However, the successful application of PTH local defect repair generally requires incorporation delivery by appropriate carriers. Though several scaffolds have developed to deliver PTH,...