A5028494561- Spinal Cord Injury Research
- Anesthesia and Pain Management
- Nerve injury and regeneration
- Pediatric Pain Management Techniques
- Opioid Use Disorder Treatment
- Surgical site infection prevention
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Knee injuries and reconstruction techniques
- Diabetic Foot Ulcer Assessment and Management
- Osteoarthritis Treatment and Mechanisms
- Immune responses and vaccinations
- Reconstructive Surgery and Microvascular Techniques
- Transcranial Magnetic Stimulation Studies
- Aortic Disease and Treatment Approaches
- Bone and Joint Diseases
- Atherosclerosis and Cardiovascular Diseases
- Macrophage Migration Inhibitory Factor
- Pain Management and Opioid Use
- Lower Extremity Biomechanics and Pathologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Wound Healing and Treatments
- Antimicrobial agents and applications
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
Shanghai Sixth People's Hospital
2019-2025
Shanghai Jiao Tong University
2019-2025
TIE Kinetix (Germany)
2024
Southern University of Science and Technology
2023
Union Hospital
2023
Fujian Medical University
2022-2023
National Natural Science Foundation of China
2020
Shanghai Municipal Education Commission
2020
Clinical Orthopaedics and Related Research
2020
Central South University
2018
Spinal cord injury (SCI) is a disorder of the central nervous system resulting from various factors such as trauma, inflammation, tumors, and other etiologies. This condition leads to impairment in motor, sensory, autonomic functions below level injury. Limitations current therapeutic approaches prompt an investigation into angiogenesis through persistent local expression proangiogenic factors. Here, we investigated whether overexpression adeno-associated virus (AAV)-mediated vascular...
Cobalt (Co) ions, which can mimic hypoxia to promote angiogenesis, exhibit great potential for bone repair. However, a key point the use of Co ions is that their release profile should be controllable and, more importantly, suitable regeneration process. Here, 2-ethylimidazole (eIm) was introduced into zeolitic imidazolate framework-67 (ZIF-67) slow down Co-ion and fabricate eIm-doped ZIF-67 (eIm/ZIF-67), combined gelatin methacrylate (GelMA) obtain an in situ photo-cross-linking...
Hydrogel-based chondrocyte implantation presents a promising tissue engineering strategy for cartilage repair. However, the widely used elastic hydrogels usually restrict cell volume expansion and induce dedifferentiation of encapsulated chondrocytes. To address this limitation, photoannealed granular hydrogel (GH) composed hyaluronic acid, polyethylene glycol, gelatin was formulated regeneration in study. The unannealed GH prepared by Diels-Alder cross-linked microgels could be mixed with...
Excessive neuroinflammation after spinal cord injury (SCI) is a major hurdle during nerve repair. Although proinflammatory macrophage/microglia-mediated plays important roles, the underlying mechanism that triggers and aggravating factors remain unclear. The present study identified role of semaphorin3C (SEMA3C) in immunoregulation SCI. SEMA3C expression level peaked 7 days post-injury (dpi) decreased by 14 dpi.
The infrapatellar fat pad and synovium are the sites of immune cell infiltration origin proinflammation. Studies have shown that Hoffa's synovitis may be a sign early-stage osteoarthritis (OA). However, there been no effective interventions specifically for synovitis. We will conduct multicentre, multi-blind (participant, physician, outcome assessor data analyst blinded) randomised controlled trial to compare effectiveness an intra-infrapatellar glucocorticoid versus intra-articular...
Vaccines could strengthen the innate immune system in addition to conferring protection against their target pathogen via vaccine-induced immunomodulation, a phenomenon termed trained immunity. The purpose of present study was determine whether vaccination prior injury is associated with lower rate bone and joint infections (BJIs) patients open extremity fractures. Patients fractures treated at one hospital between January 2010 December 2019 were identified. Incidental vaccine recipients...
Traumatic spinal cord injury (SCI) is a major clinical challenge, imposing significant burden on both patients and healthcare systems. The complexity of SCI stems from its multifactorial pathogenesis, incorporating variety regulating factors. Despite the exploration mechanisms pathophysiology development biomedical therapies, current interventions are still limited to surgical rehabilitative care. This study introduces an approach protect mitochondria-a pivotal factor in pathogenesis-through...
To explore the mechanism of antibiotic delivery system targeting bacterial biofilm with linezolid (LZD) based on ε-poly- L-lysine (ε-PLL) and cyclodextrin (CD) (ε-PLL-CD-LZD), aiming to enhance bioavailability, effectively penetrate disrupt structures, thereby improve treatment bone joint infections. ε-PLL-CD-LZD was synthesized via chemical methods. The grafting rate CD characterized using nuclear magnetic resonance. In vitro biocompatibility evaluated through live/dead cell staining after...
Free and liposome-encapsulated amikacin are active in vitro against intracellular Mycobacterium avium complex (MAC). To examine whether aminoglycosides might kill MAC more effectively vivo, beige mice were infected with strain 101 (serotype 1) after 1 week treated intravenously every other day (5 doses total) liposomes (0.2, 1, or 4 mg/dose), solution 2 mg), gentamicin (0.2 placebo (without aminoglycosides), buffer. Amikacin significantly reduced bacterial counts blood, liver, spleen (98.5%,...
Aims To investigate the efficacy of ethylenediaminetetraacetic acid-normal saline (EDTA-NS) in dispersing biofilms and reducing bacterial infections. Methods EDTA-NS solutions were irrigated at different durations (1, 5, 10, 30 minutes) concentrations 2, 50 mM) to disrupt Staphylococcus aureus on Matrigel-coated glass two materials widely used orthopaedic implants (Ti-6Al-4V highly cross-linked polyethylene (HXLPE)). assess biofilm dispersion, crystal violet staining assay colony counting...
Abstract Undergraduate research (UR) refers to a series of scientific activities for undergraduates. For the past few years in China, medical colleges and universities have increasingly attached importance on UR, aiming provide undergraduates with better conditions, improve their understanding about basic skills. Chinese participate spontaneously. However, specific effects UR are still unclear. In quantitative standards evaluate detailed roles undergraduates' available yet. To explore how...
To evaluate inducing osteoarthritis (OA) by surgical destabilization of the medial meniscus (DMM) in mice with and without a stereomicroscope.Based on sample size calculation, 70 male C57BL/6 were randomly assigned to three surgery groups: DMM aided stereomicroscope; naked eye; or sham surgery. The group information was blinded researchers. Mice underwent static weightbearing, von Frey test, gait analysis at two-week intervals from eight 16 weeks after Histological grade OA determined...
Abstract Background Displaced patellar fractures are commonly treated with open reduction and fixation several different types of tension-band (TB) constructs. The main objective this study was to compare the prevalence postoperative complications after surgical stabilization comminuted either a modified Kirschner-wire tension band (MKTB), cannulated-screw (CSTB), or ring-pin (RPTB). Methods We conducted retrospective consecutive cohort ( n = 334) stabilized using TB construct. Postoperative...
Abstract Background The extensive functional and structural remodeling that occurs in the brain after amputation often results phantom limb pain (PLP). These closely related phenomena are still not fully understood. Methods Using magnetic resonance imaging (MRI) graph theoretical analysis (GTA), we explored how alterations cortical thickness (CTh) covariance networks (SCNs) upper amputees (ULAs) relate to PLP. In all, 45 ULAs healthy controls (HCs) underwent MRI. Regional network properties,...
Microsurgical anastomosis is technically difficult especially for less-experienced surgeons. Traditionally, surgeons in training could only accomplish these surgeries under intensive guiding and supervision from senior This study presents characterises a new method microsurgical trainees to objectively evaluating the quality of vascular intraoperatively.We conducted prospective determine utility patency test with assistance high-speed video recording (PTHVR) evaluate during microsurgery. To...
Background: Failure of digit replantation after traumatic amputation is difficult to predict. We aimed develop a prognostic model better identify factors that predict failure following amputation. Materials and methods: In this multicenter prospective cohort, we identified patients who had received between January 1, 2015, 2019. Univariable multivariable analyses were performed successively independently predictive for replanted digit. To reduce overfitting, the Bayesian information...
Abstract Local anesthetics as a part of intraarticular therapies (IATs) are widely used for treating knee osteoarthritis (KOA). Whether substitution liposomal bupivacaine (LB) lidocaine is safe and effective in reducing incidence injection-emergent adverse events after IATs remains unclear. Methods We recruited outpatients who had clinical diagnosis KOA decided to receive from November 2023 April 2024. The type IAT (glucocorticoids, platelet-rich plasma hyaluronic acid) each participant was...