A5100383658- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Fibroblast Growth Factor Research
- Renal Diseases and Glomerulopathies
- Pectus Deformity Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Head and Neck Cancer Studies
- Multiple Myeloma Research and Treatments
- Melanoma and MAPK Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cytomegalovirus and herpesvirus research
- Cancer-related gene regulation
- Organ and Tissue Transplantation Research
- Mast cells and histamine
- Cancer-related Molecular Pathways
- Kruppel-like factors research
- Gout, Hyperuricemia, Uric Acid
- Cutaneous Melanoma Detection and Management
- Child Abuse and Related Trauma
Shanxi Medical University
2025
Shanghai Ninth People's Hospital
2017-2024
Shanghai Jiao Tong University
2010-2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Zhejiang Provincial People's Hospital
2024
Soochow University
2023
National Clinical Research Center for Digestive Diseases
2019-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Shanghai Chest Hospital
2020
Unlike advances in the genomics-driven precision treatment of cutaneous melanomas, current poor understanding molecular basis mucosal melanomas (MM) has hindered such progress for MM patients. Thus, we sought to characterize genomic landscape identify alterations with prognostic and/or therapeutic implications.Whole-genome sequencing (WGS) was performed on 65 samples, including 63 paired tumor blood samples and 2 matched lymph node metastases, a further droplet digital PCR-based validation...
Abstract Stimuli‐responsive nanomedicines have become a recent research focus as candidate for cancer treatment because of their effectiveness, sensibility, and minimal invasiveness. In this work, novel nanosystem is developed based on Cu 2− x S@MnS core–shell nanoparticles (CSNPs) in which the S core serves photosensitizer to generate hyperthermia reactive oxygen species (ROS), MnS shell used H 2 O ‐responsive production. −x CSNPs with an independent ratio are synthesized by controllable...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor with poor clinical outcomes due to recurrence, metastasis, treatment resistance. Cancer stem cells (CSCs), small population among cells, are proposed be responsible for initiation, progression, drug resistance, recurrence. Here we show that high LSD1 expression was predictor of prognosis HNSCC patients. We found essential the maintenance CSC properties by regulating Bmi-1 expression. Moreover, ablation...
Although N6-methyladenosine (m6A) may be related to the pathogenesis of fibrotic process, mechanism m6A modification in aging-related idiopathic pulmonary fibrosis (IPF) remains unclear. Three-milliliter venous blood was collected from IPF patients and healthy controls. MeRIP-seq RNA-seq were utilized investigate differential modification. The expressions identified regulator target gene validated using MeRIP-qPCR real-time PCR. Moreover, we established an animal model a senescent A549 cells...
In precision cancer nanomedicine, the key is to identify oncogenes that are responsible for tumorigenesis, based on which these genetic drivers can be each specifically regulated by a nanovector-directed, oncogene-targeted microRNA (miRNA) tumor suppression.Fibroblast Growth Factor Receptor 3 (FGFR3) such an oncogene.The molecular tumor-subtype harboring FGFR3 genomic alteration has been identified via sequencing and referred as FGFR3-driven tumors.This genomics-based classification provides...
Programmed death-ligand 1 (PD-L1) expression has been approved as an immune checkpoint inhibitor (ICI) response predictive biomarker; however, the clinicopathological and molecular features of HPV-positive oropharyngeal squamous cell carcinoma [HPV(+)OPSCC] based on PD-L1 are not well studied. We aimed to characterize clinicopathological, tumor microenvironmental, HPV(+)OPSCC with different scored by combined positive score (CPS). A total 112 cases were collected from 2008-2021 received CD8...
Tertiary lymphoid organs (TLOs) have been described within organ allografts, but whether they promote destructive or beneficial alloimmune responses remains controversial. This study aimed to characterize TLO distribution in human chronically rejected renal allografts and explore their functions.A total of 29 explanted 12 acutely were analyzed by immunohistochemistry. The TLOs, T cells, follicular dendritic B regulatory (Tfr) as well Ki67, peripheral lymph node addressin (PNAd), podoplanin,...
Rationale: Mutations in KIT, a major cancer driver gene, are now considered as important drug targets for the treatment of melanomas arising from mucosal and acral tissues chronically sun-damaged sites. At present, imatinib is only targeted KIT-mutation-bearing that recommended by National Comprehensive Cancer Network (NCCN) Clinical Practice guidelines. Patients with KIT mutations, however, either insensitive or rapidly progress to insensitivity, which restricts its clinical use. Thus,...
Mucosal melanoma has characteristically distinct genetic features and typically poor prognosis. The lack of representative mucosal models, especially cell lines, hindered translational research on this subtype. In study, we aimed to establish provide the biological properties, genomic pharmacological profiles a line that would contribute understanding treatment optimization molecularly-defined
ABSTRACT Objectives Porphyromonas gingivalis ( P. ) is a keystone periodontal pathogen associated with various gastro‐intestinal tract cancers. However, whether can promote oral squamous cell carcinoma (OSCC) and the underlying mechanism such promotion remain unclear. Materials Methods In this study, OSCC xenograft models were used to evaluate effects of on tumor progression. The functional studies done several lines in vitro. ‐specific 16S rRNA fluorescent situ hybridization (FISH) was test...
The aim of this study was to evaluate the efficacy and safety non-thoracoscopic extrapleural approach Nuss procedure for correction pectus excavatum in children.From October 2007 January 2009, 42 patients with were treated Tangdu Hospital, Xi'an, China, surgical through procedure. Among them, 20 underwent a thoracoscopic guidance, other 22 approach, which bilateral tunnel edge sternum created using blunt dissection thoracic skin incisions. Without introducing thoracoscopy into cavity, steel...
The prognosis of HPV- HNSCC was worse than that HPV+ HNSCC. Analysis tumours and tumour-infiltrating lymphocytes (TILs) may provide insight into the progression HNSCC.The tumour TIL phenotypic characteristics 134 specimens (HPV- were classified "Infiltrating" "Pushing" subtypes based on their different nest configuration prognosis) retrospectively analysed. data from Cancer Genome Atlas (n = 263) analysed for CD8α, HPV overall survival (OS). A murine model used to verify antitumour role...
The fibroblast growth factor receptor (FGFR) members including FGFR1-4 have been identified as promising novel therapeutic targets and prognostic markers in multiple solid tumors. However, the predictive role of expression FGFR proteins oral squamous cell carcinoma (OSCC) requires further exploration.
Abstract Objectives Antiangiogenic inhibitors have been shown to synergize with immune checkpoint blockade, but the underlying mechanisms of synergistic response are not fully understood. Patients and Methods We investigate impact VEGFR2 inhibition on tumor‐infiltrating cells in vivo activity combination apatinib anti‐PD‐1 mouse model HNSCC. A patient squamous cell carcinoma left tongue cervical lymph node were received combined induction treatment camrelizumab validate efficacy neoadjuvant...
Oesophagectomy is at present considered to be the optimal curative treatment for patients with severe oesophageal disease. Postoperative pain, both acute and chronic, plays a significant role in quality of life post-oesophagectomy patients. The study compared effects two methods—application non-divided intercostal muscle flap (NIMF) nerve cryoanalgesia (INC) treatment—in reducing neuropathic pain From June 2009 2010, total 160 who underwent posterolateral thoracotomy oesophagectomy were...
Emerging evidence indicates that natural killer (NK) cells and NKT‑like may affect allograft outcomes following solid organ transplantation. However, the roles of these in acceptance dysfunction are controversial. To assess changes NK cell CD3+CD56+ frequency phenotype renal recipients to explore their associations with acute T‑cell‑mediated rejection (ACR), longitudinal were characterized using flow cytometry immunohistochemistry peripheral blood kidney tissues 142 undergoing The serum...
Esophagopericardial fistula (EPF) is an uncommon complication of esophageal disease. Although, the esophagus in direct contact with pericardium lower thoracic vertebrae level, EPF still rare. Recorded causes include ingested foreign bodies such as fish bone, benign ulceration association hiatus hernia, carcinoma, and achalasia. Congenital occurs even less but a high ratio mortality misdiagnosis. We present case PEF 1-year-old boy. It unique that patient was very young child which rarely...
Salivary adenoid cystic carcinoma (SACC), a rare cancer arising in the salivary glands, is characterized by high rates of relapse and distant metastasis. Epidermal growth factor receptor (EGFR) has been implicated SACC carcinogenesis. However, prospective trials EGFR-targeting therapies are limited, optimum regimen unclear.The effects erlotinib on cell proliferation, colony formation, ALDH enzymatic activity tumorsphere formation were investigated cells. Expression stem markers Bmi-1 Oct4...
Antibody-mediated rejection (AMR) is an important factor affecting survival after renal transplantation.A highly selective proteasome inhibitor, bortezomib, clears activated plasma cells from the body and has therapeutic effect on AMR.We investigated effects of bortezomib AMR in a patient second transplant.Biopsy confirmed diagnosis mixed cellular AMR.Bortezomib was administered day 1 (1.3 mg/m 2 ), 4 (1.0 8 ).On same days, 250 mg methylprednisolone once, cyclosporine dose (5 mg•kg -1 •day )...
Background and aims Pediatric dilated cardiomyopathy (DCM) is a primary cause of heart failure, highlighting the urgent need for effective prognostic markers. Methods We performed single-center retrospective study involving 145 children diagnosed with DCM, median follow-up period 4.0 months (interquartile range: 6.2–108.4 months). The relationship between serum uric acid (SUA) levels all-cause mortality was assessed using Kaplan–Meier survival curves, multivariate Cox proportional hazard...
Pediatric heart failure (HF) is associated with high readmission rates, but the optimal serum potassium range for this population remains unclear. In single-center retrospective cohort study, 180 pediatric patients hospitalized HF between January 2016 and 2022 were stratified into low-potassium (<3.7 mmol/L), middle-potassium (3.7–4.7 high-potassium (≥4.7 mmol/L) groups based on distribution of levels in study population. The primary outcome was within 1 year discharge. Cox regression...