A5100356894- Cancer, Stress, Anesthesia, and Immune Response
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- 3D Printing in Biomedical Research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Cancer Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Sperm and Testicular Function
- Advanced biosensing and bioanalysis techniques
- Advanced Technologies in Various Fields
- Intracranial Aneurysms: Treatment and Complications
- Estrogen and related hormone effects
- Ovarian function and disorders
- Gut microbiota and health
- Microfluidic and Bio-sensing Technologies
- Ovarian cancer diagnosis and treatment
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Renal and related cancers
Shandong Academy of Sciences
2025
Qilu University of Technology
2025
Shanghai Jiao Tong University
2017-2024
Shanghai Ninth People's Hospital
2024
Nanchang University
2022
First Affiliated Hospital of Nanchang University
2022
International Peace Maternity & Child Health Hospital
2017-2020
Tianjin Nankai Hospital
2020
Linyi People's Hospital
2020
Shanghai Municipal People's Government
2020
Novel nanoMof (Tf-LipoMof@PL) can induce both ferroptosis and pyroptosis by iron ROS enrichment, which provides new choices for anti-cancer therapy.
Perineural invasion (PNI) has guiding significances for nerve preservation in cervical cancer, but there is no definite marker indicating PNI. Two cancer cell lines (HeLa and ME-180) showed significant abilities to migrate along neurites vitro vivo. Morphological observation revealed that Schwann cells (SC) arrived at the sites of before onset metastasis. We used high-throughput antibody array screen signals mediating interaction found high expression CCL2 dorsal root ganglion (DRG)....
Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ pro-tumorigenic effects induced by chronic breast remains unknown. Herein, we have characterized a novel role vascular endothelial growth factor (VEGF)/fibroblast 2 (FGF2) signals promoted stress.We performed experiments vivo vitro used bioinformatics data to evaluate therapeutic...
We explore a sandwich-type gold nanoparticle coated reduced graphene oxide (rGO-AuNP) as an effective nanotheranostic platform for the second near-infrared (NIR-II) window photoacoustic (PA) imaging-guided photothermal therapy (PTT) in ovarian cancer. The PEG was loaded onto AuNPs surface to increase stability of nanostructure. forming rGO-AuNPs- revealed very strong SERS signal, NIR-II PA signal and high efficiency against tumor upon 1,061 nm laser irradiation. prominent performance...
How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is the first time reported that new based on bonding polydimethylsiloxane channels onto substrate screen-printed electrode with coating glass solution was fabricated electrochemical sensing prostate-specific antigen (PSA). Compared traditional microfabrication processes, this method simple, fast, low cost, and also suitable mass production. The prepared electrode-based...
Background Bladder cancer (BLCA) is a challenging malignancy with poor prognosis, particularly in muscle-invasive cases. Despite recent advancements immunotherapy, response rates remain suboptimal. This study investigates the role of METTL3, an m6A RNA methylation “writer,” regulating immune microenvironment BLCA. Methods Through bioinformatics analysis, we identified METTL3 as being associated formation immunosuppressive BLCA and to immunotherapy. Subsequently, silenced expression cells...
ABSTRACT Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood. Hypoxia can lead to neuronal cell death and angiogenesis, the same mechanisms were also found in epilepsy. Hypoxia‐inducible factor‐1α (HIF‐1α) an important transcription protein that regulates gene expression brain other tissues response decreases oxygen availability. However, little known regarding of HIF‐1α epileptic whether interventions affect process. The aims this study...
The aggressive progression of breast cancer is impacted significantly by the tumor microenvironment (TME). current chemotherapy normally causes cytotoxicity to cells, while does not effectively modulate TME. Thus, effect usually dissatisfactory. In this study, a kind hierarchically releasing bio-responsive nanoparticles (R(D)/H(S) NPs), constructed β-cyclodextrin-grafted heparin and pH-sensitive pseudorotaxane, were investigated enhance chemotherapeutic efficacy through TME modulation....
A microfluidic chip with single-sided herringbone microstructure has been developed to isolate circulating tumor cells (CTCs) from blood samples of cancer patients. Here, we describe a new double-sided in which staggered micromixers are placed on both top and bottom surfaces microchannels. The structure enables high CTC capture efficiency whole without depletion red because the effects leukocyte margination plasma skimming. However, compared traditional chip, more complicated geometrical...
Celiac disease exhibits a higher prevalence among patients with coronavirus 2019. However, the potential influence of COVID-19 on celiac remains uncertain. Considering significant association between gut microbiota alterations, and disease, two-step Mendelian randomization method was employed to investigate genetic causality as mediators. We genome-wide study select instrumental variables associated exposure. Subsequently, these were utilized evaluate impact risk its microbiota. Employing...
Perineural invasion (PNI) is the neoplastic of nerves by cancer cells, a process that may prove to be another metastatic route besides direct invasion, lymphatic spread, and vascular dissemination. Given increasing incidence association with poor prognosis, revealing pathogenesis perineural great importance.Four datasets related PNI were downloaded from Gene Expression Omnibus database used construct weighted gene co-expression network analysis (WGCNA). The intersection potential pathways...
Intracranial aneurysm (IA) is the most common and main cause of spontaneous subarachnoid hemorrhage (SAH). The underlying molecular mechanisms for preventing IA progression have not been fully identified. Our research aimed to identify key genes critical pathways through gene co-expression networks.Gene Expression Omnibus (GEO) datasets GSE13353, GSE54083 GSE75436 were used in study. genetic data analyzed by weighted network analysis (WGCNA). Then clinically significant modules identified...
Pancreatic cancer is a common malignant tumor of the digestive system, and its incidence increasing worldwide. The treatment pancreatic mainly surgery, but development traditional chemoradiotherapy has entered plateau stage, immunotherapy received more attention. Different anesthesia methods, anaesthetic drugs their preparations have different effects on perioperative immune function patients with cancer, even affect long-term prognosis patients. Suppression caused by surgery may promote...
Circulating tumor cells (CTCs) are free shed from site and enter into blood circulation. CTCs represent a reliable source of for the molecular characteristics original tumor. However, extraordinary rarity makes subsequent functional analysis technically challenging. Here, we describe one-step microfludics-based immunomagnetic isolation method to isolate directly whole lung adenocarcinoma patients. This avoids harsh sample preparation enrichment steps, therefore preserves viability (>90%)...