A5101553443- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Plant Molecular Biology Research
- RNA Research and Splicing
- RNA modifications and cancer
- Circular RNAs in diseases
- Enzyme Production and Characterization
- Genetics, Aging, and Longevity in Model Organisms
- Quinazolinone synthesis and applications
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Protein Hydrolysis and Bioactive Peptides
- Metabolism, Diabetes, and Cancer
- Protist diversity and phylogeny
- Synthesis and biological activity
- Muscle metabolism and nutrition
- Microbial Metabolism and Applications
- Glutathione Transferases and Polymorphisms
- Bioactive Natural Diterpenoids Research
- Pharmacological Effects of Natural Compounds
- Cytokine Signaling Pathways and Interactions
- Enzyme Catalysis and Immobilization
- Marine Toxins and Detection Methods
- Cholesterol and Lipid Metabolism
- Phytochemistry and biological activity of medicinal plants
Shaanxi University of Chinese Medicine
2022-2025
Sichuan Tourism University
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Nanchang University
2022-2024
Xuzhou Medical College
2023
Xuzhou No.1 People's Hospital
2023
Sun Yat-sen University
2023
Abstract Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for synthesis of glycerolipids, interacts with is a direct substrate Src proto-oncogenic tyrosine kinase. Obesity-associated microenvironmental factors other Src-activating growth factors, including epidermal factor, activate promote...
Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ pro-tumorigenic effects induced by chronic breast remains unknown. Herein, we have characterized a novel role vascular endothelial growth factor (VEGF)/fibroblast 2 (FGF2) signals promoted stress.We performed experiments vivo vitro used bioinformatics data to evaluate therapeutic...
Background: Chemoresistance contributes to treatment failure of gastric cancer (GC) patients but the molecular mechanism chemoresistance in GC is still unclear. Long-chain noncoding RNA (lncRNA) urothelial associated 1 ( UCA1 ) with resistance chemotherapy drugs. Methods: We detected expression 53 pairs tumor tissue and adjacent normal tissue, human mucosa cells (GES-1) (HGC-27, SNU-5, AGS, SGC-7901, NCI-N87) using RT-qPCR. Small interference technology was used knock down cells. CCK8...
Gut bacterial β-glucuronidase is an important molecular target in several therapeutic applications. inhibitors can effectively alleviate gastrointestinal toxicity caused by certain drugs. Licorice, a traditional Chinese medicine, harmonizes various herbs and mitigates the of hundreds herbs. In this study, comprehensive computational strategy was employed to evaluate four licorice flavonoids (liquiritigenin, isoliquiritigenin, liquiritin, isoliquiritin) as potential Escherichia coli (EcGUS)...
Ferroptosis is a form of cell death that triggered by iron-dependent lipid peroxidation and closely associated with osteoarthritis. The primary interventions for inhibiting ferroptosis in osteoarthritis are anti-lipid iron chelation. objective our study to investigate the characteristics identify optimal time points alleviate disease progression. Ferroptosis-related alterations markers OA were analyzed paired intact damaged cartilages from patients immunofluorescence, qRT-PCR, mitochondrial...
To construct a urine extracellular vesicle long non-coding RNA (lncRNA) classifier that can detect high-grade prostate cancer (PCa) of grade group 2 or greater and estimate the risk progression during active surveillance, we identify PCa-specific lncRNAs by combined analyses cohorts from TAHSY, TCGA, GEO database. We develop validate 3-lncRNA diagnostic model (Clnc, being made AC015987.1, CTD-2589M5.4, RP11-363E6.3) PCa. Clnc shows higher accuracy than antigen 3 (PCA3), multiparametric...
In this study, tomato seed (TS) samples were subjected to different roasting conditions (90–170 °C and 10–30 min) compare their effects on the chemical composition oxidative stability of oil (TSO). Unroasted TS was considered as a control sample. Our results revealed that moderate (130 °C/20 can significantly increase content linoleic acid (54.01–54.89%), linolenic (2.17–2.41%), phytosterols (2789.56–3037.31 mg/kg), squalene (5.06–13.10 total phenols (22.37–22.67 mg GAE/100 g), other...
The dietary exposures to fatty esters of 3- and 2-monochloropropanediol (MCPD) glycidol were estimated for children aged 2- 3-year-old from two areas China using duplicate diet collection method. 24-h daily samples over three consecutive days collected 40 healthy between 26 36 months. analysis these contaminates in food was measured by an indirect method that entails MCPD/glycidol cleavage their esterified forms GC-MS analysis. Over 71% the mixed dairy products found be contaminated with...
Evodiamine (EVO) and rutaecarpine (RUT) are the main active compounds of traditional Chinese medicinal herb Evodia rutaecarpa. Here, we fully optimized molecular geometries EVO RUT at B3LYP/6-311++G (d, p) level density functional theory. The natural population analysis (NPA) charges, frontier orbitals, electrostatic potentials, chemical reactivity descriptors for were also investigated. Furthermore, docking, dynamics simulations, binding free energies carried out against anticancer target...
Ovarian cancer (OC) has the highest fatality rates of all gynecological malignancies worldwide. The epithelial‑to‑mesenchymal transition (EMT) serves an essential role in progression OC. An improved understanding molecular mechanism underlying EMT OC may increase survival rate. ATP‑binding cassette transporter A7 (ABCA7) is a candidate regulator progression. However, ABCA7 unclear. Using PROGgeneV2 platform, present study revealed that increased expression associated with poor outcomes was...
This study evaluates the antioxidant potential and cytoprotective effects of ethanolic crude extract from Clerodendrum cyrtophyllum leaves (ECE) five derived fractions (namely, petroleum ether fraction (PEF), dichloromethane (DMF), ethyl acetate (EAF), n-butyl alcohol (BAF) remaining (RF)), as well acteoside (Ac, a major phenolic component in EAF) on oxidative damage caused by tert-butyl hydroperoxide (t-BHP) HepG2 cells. MTT assay results showed that ECE, EAF, BAF, RF Ac increased viability...
Skeletal muscle differentiation is a precisely coordinated process. While many of the molecular details myogenesis have been investigated extensively, dynamic changes and functions amino acids related transporters remain unknown. In this study, we conducted comprehensive analysis acid levels during different time points C2C12 myoblast using high-performance liquid chromatography (HPLC). Our findings revealed that most exhibited an initial increase at onset differentiation, reaching their...
Introduction: Human topoisomerase 1 (TOP1) is an important target of various anticancer compounds. The design and discovery inhibitors targeting TOP1 are great significance for the development drugs. Evodiamine thieno [2,3-d] pyridine hybrids show potential antitumor activity. Herein, anti-gastric cancer activities these were investigated. Methods: inhibitory effects different concentrations ten evodiamine derivatives on gastric cell line SGC-7901 assessed using a methyl thiazolyl...
The regenerative capacity of muscle, which primarily relies on anabolic processes, diminishes with age, thereby reducing the effectiveness therapeutic interventions aimed at treating age-related muscle atrophy. In this study, we observed a decline in expression methionine adenosine transferase 2A (MAT2A), synthesizes S-adenosylmethionine (SAM), tissues both aged humans and mice. Considering MAT2A’s critical role anabolism, hypothesized that its reduced contributes to impaired aging skeletal...