A5103003594- Angiogenesis and VEGF in Cancer
- Immune Response and Inflammation
- Plant biochemistry and biosynthesis
- Viral Infectious Diseases and Gene Expression in Insects
- Synthesis and biological activity
- Water Quality Monitoring and Analysis
- Neurobiology and Insect Physiology Research
- Synthesis and Biological Evaluation
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Quinazolinone synthesis and applications
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Plant Pathogens and Fungal Diseases
- Invertebrate Immune Response Mechanisms
- Teleoperation and Haptic Systems
- Anodic Oxide Films and Nanostructures
- PI3K/AKT/mTOR signaling in cancer
- Galectins and Cancer Biology
- Biochemical Analysis and Sensing Techniques
- Organic Light-Emitting Diodes Research
- Liver physiology and pathology
- Analytical Chemistry and Chromatography
- FOXO transcription factor regulation
Hubei Cancer Hospital
2022-2024
Southwest University
2018-2024
Shaanxi University of Chinese Medicine
2022-2024
Jiangnan University
2022-2023
State Key Laboratory of Silkworm Genomic Biology
2018-2022
Wenzhou Medical University
2021-2022
Zhejiang Center for Disease Control and Prevention
2022
Peking University
2021
University of Chinese Academy of Sciences
2019
Shenzhen University
2011-2017
Matrix metalloproteinases (MMPs) secreted by ovarian cancer play essential roles in tumor invasion and metastasis. In this study, we investigated the effect of baicalein, which is isolated from traditional Chinese herbal medicine Scutellaria baicalensis Georgi, on human cell lines measuring MMP-2 expression, invasive potential, underlying molecular mechanisms. Analysis was carried out western blots RT-PCR. The ability cells determined using a Transwell assay. Nuclear factor-κB (NF-κB) p38...
Abstract Epithelial barrier integrity is critical to maintain the homeostasis in body. The regulatory mechanism of epithelial function has not been fully understood. This study aims elucidate role TWIK-related potassium channel-1 (Trek1) regulation nasal mucosa. In this study, levels Trek1 were assessed by real time RT-PCR and Western blotting. rat epithelia was evaluated Ussing chamber system. results showed that detected human epithelia, which significantly lower patients rats with...
Platelet-derived growth factor receptors (PDGFRs) are now considered promising targets for the treatment of osteosarcoma. Herein, design, synthesis, and structure–activity relationships (SAR) novel pyrimidine-2,4-diamine derivatives that selectively inhibit PDGFRα/β kinases have been studied. The screening cascades revealed 7m was preferred compound among these derivatives, with IC50 values 2.4 0.9 nM PDGFRα PDGFRβ, respectively. Moreover, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...
Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate mechanism by which epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates inflammatory responses. In this study, production TSP1 cells was evaluated quantitative real-time PCR Western blotting. The Mos were analyzed flow cytometry. A mouse model colitis created assess epithelium-derived suppression results demonstrated that (IECs)...
Evodiamine (EVO) and rutaecarpine (RUT) are the main active compounds of traditional Chinese medicinal herb Evodia rutaecarpa. Here, we fully optimized molecular geometries EVO RUT at B3LYP/6-311++G (d, p) level density functional theory. The natural population analysis (NPA) charges, frontier orbitals, electrostatic potentials, chemical reactivity descriptors for were also investigated. Furthermore, docking, dynamics simulations, binding free energies carried out against anticancer target...
The epithelial barrier dysfunction plays a critical role in the pathogenesis of broad array immune diseases. Alix protein is involved endolysosome system. This study aims to elucidate maintenance function.The results showed that was detected T84 cells at both mRNA and levels. Exposure Staphylococcal enterotoxin B (SEB) markedly suppressed expression cells, which could be blocked by knocking down Toll like receptor 2. exposure SEB did not affect TER, but increased permeability monolayers OVA;...
Saccharomyces cerevisiae has been extensively used as a convenient synthetic biology chassis to reconstitute fungal polyketide biosynthetic pathways. Despite progress in refactoring these pathways for expression and optimization of the yeast production host by metabolic engineering, product yields often remain unsatisfactory. Such problems are especially acute when biological is bioprospecting via genome mining or chimeric synthases (PKSs) employed produce novel bioactive compounds. In this...
Our colleagues have reported previously that human pancreatic progenitor cells can readily differentiate into insulin-containing cells. Particularly, transplantation of these cell clusters upon in vitro induction for 3-4 w partially restores hyperglycemia diabetic nude mice. In this study, we used fetal to identify the forkhead protein FoxO1 as key regulator differentiation. Thus, 1 week led increase <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract The silkworm, Bombyx mori , is one of the world's most economically important insect. Surveying variations in gene expression among multiple tissue/organ samples will provide clues for function assignments and be helpful identifying genes related to economic traits or specific cellular processes. To ensure their accuracy, commonly used quantification methods require a set stable reference data normalization. In this study, 24 candidate were assessed 10 day 3 fifth‐instar B. larvae...
Abstract Isopentenylation at A37 (i 6 A37) of some transfer RNAs (tRNAs) plays a vital role in regulating the efficiency and fidelity protein synthesis. However, whether insects, which are well known for their highly efficient synthesis machinery, employ this regulatory mechanism remains uninvestigated. In current study, candidate tRNA isopentenyltransferase (IPT) gene with three alternative splicing isoforms ( BmIPT1 – BmIPT3 ) was identified Bombyx mori (silkworm). Only could complement...
The design of blue emitters is still desired for high performance organic light-emitting diodes (OLEDs).
Introduction: Human topoisomerase 1 (TOP1) is an important target of various anticancer compounds. The design and discovery inhibitors targeting TOP1 are great significance for the development drugs. Evodiamine thieno [2,3-d] pyridine hybrids show potential antitumor activity. Herein, anti-gastric cancer activities these were investigated. Methods: inhibitory effects different concentrations ten evodiamine derivatives on gastric cell line SGC-7901 assessed using a methyl thiazolyl...
Understanding the evolutionary genetics of food intake regulation in domesticated animals has relevance to biology, animal improvement, and obesity treatment. Here, we observed that fatty acid desaturase gene (Bmdesat5), which regulates intake, is suppressed silkworms, but expressed salivary glands wild silkworm Bombyx mandarina. The content its catalytic product, cis-vaccenic acid, was related expression levels Bmdesat5 strains. These two strains also showed significant differences intake....
The quest to understand how the immune system maintains balance is one of most pressing scientific inquiries highlighted by "Science" magazine. Autoimmune diseases and immune-mediated kidney are primarily attributed dysregulation. Typically, interventions such as steroids, other immunosuppressants, biologics required, but these expose patients a heightened risk infections. We became intrigued category drugs known immunomodulators, specifically Thymosins, which may possess both negative...