A5101799012- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Inflammasome and immune disorders
- Microscopic Colitis
- Extracellular vesicles in disease
- Pediatric health and respiratory diseases
- Phagocytosis and Immune Regulation
- Toxin Mechanisms and Immunotoxins
- Epigenetics and DNA Methylation
- Barrier Structure and Function Studies
- Biochemical Analysis and Sensing Techniques
Shenzhen University
2015-2024
Shenzhen Third People’s Hospital
2023-2024
Guangdong Provincial Center for Disease Control and Prevention
2023-2024
Southern Medical University Shenzhen Hospital
2018-2023
Key Laboratory of Guangdong Province
2022-2023
Precision for Medicine (United States)
2022
Health Sciences Centre
2022
Longgang Central Hospital
2016-2020
Eye & ENT Hospital of Fudan University
2019
Southern Medical University
2019
Dendritic cells (DCs) that express T cell immunoglobulin domain molecule-4 (TIM4), a surface receptor for phosphatidylserine, induce helper 2 (T H 2) responses and allergic reactions. We elucidated the role of transcription factor X-box–binding protein-1 (XBP1) in induction response through its generating TIM4 + DCs. found XBP1 was required mRNA protein expression airway DCs to cytokine interleukin-2 (IL-2) this pathway on allergens PM2.5 Derf1. The IL-2–XBP1–TIM4 axis contributed...
Specific immunotherapy (SIT) is the only specific remedy for treatment of allergic diseases currently. B cells are important immune in immunity. The role regulatory activities has not been fully understood yet. This study aims to elucidate thrombospondin (TSP)1-producing SIT. results showed that after SIT, frequency CD35(+) was increased intestine mice with food allergy. expressed TSP1 exposure antigens. Co-culture TSP1-producing decreased levels CD80/CD86 dendritic cells; convert naïve...
Abstract The pathogenesis of some chronic inflammation such as inflammatory bowel disease is unclear. Insulin-like growth factor-1 (IGF1) has active immune regulatory capability. This study aims to investigate into the mechanism by which IGF1 modulates monocyte (Mo) properties inhibit in intestine. In this study, production intestinal epithelial cells was evaluated real time RT-PCR and Western blotting. Mos were analyzed flow cytometry. A mouse colitis model created with trinitrobenzene...
Abstract Epithelial barrier integrity is critical to maintain the homeostasis in body. The regulatory mechanism of epithelial function has not been fully understood. This study aims elucidate role TWIK-related potassium channel-1 (Trek1) regulation nasal mucosa. In this study, levels Trek1 were assessed by real time RT-PCR and Western blotting. rat epithelia was evaluated Ussing chamber system. results showed that detected human epithelia, which significantly lower patients rats with...
Cancer metastasis is the cause of majority cancer-related deaths. In this study, we demonstrated that no expression or low ATP11B in conjunction with high PTDSS2, which was negatively regulated by BRCA1, markedly accelerates tumor metastasis. Further analysis revealed cells and PTDSS2 (ATP11BloPTDSS2hi cells) were associated poor prognosis enhanced breast cancer patients general. Mechanistically, an ATP11BloPTDSS2hi phenotype increased levels nonapoptotic phosphatidylserine (PS) on outer...
Abstract Interleukin (IL)-33 is a key driver of T helper 2 (Th2) cell polarization. Endoplasmic reticulum (ER) stress plays role in the skewed activation. The objective this project to elucidate IL-33 derived from macrophages inducing Th2 polarization airways. In study, bronchoalveolar lavage fluids (BALF) were collected patients with asthma and healthy control subjects. Macrophages isolated BALF by flow cytometry sorting. An asthmatic mouse model was established using ovalbumin/alum...
CpG oligodeoxynucleotide (CpG-ODN; CpG, in short) has been employed as an adjuvant allergen specific immunotherapy (AIT) to treat allergic diseases. The underlying mechanism needs be further explained. aim of this study is examine the by which and dust mite extracts (DME, a antigen) alleviate experimental airway allergy. DME was used establish allergy mouse model. mice were directly exposed through nasal instillations (the CpG.DME therapy). response DCs responses airways assessed using...
Epithelial barrier dysfunction is involved in a large number of diseases, but the pathogenesis unclear. Integrin alphavbeta6 (avb6) maintenance mucosal homeostasis. We have investigated role avb6 maintaining epithelial function. Using T84 monolayers cultures, transepithelial electric resistance (TER) and permeability to ovalbumin (OVA) were measured as indicators functioning. The antigenicity OVA collected from Transwell basal chambers was assessed using OVA-specific T cell proliferation....
Background The interleukin (IL)‐10 expression in B cells plays an important role immune tolerance. regulation of IL‐10 is not fully understood yet. Tumor necrosis factor (TNF) increased allergic rhinitis (AR) patients. This study tests a hypothesis that TNF enhances histone deacetylase (HDAC)11 to inhibit the AR Methods Peripheral were collected from healthy persons and patients with AR. analyzed by assay molecular biological approaches for IL‐10. Results HDAC11 was higher than persons....
Abstract The abnormality of immune regulation plays a critical role in the pathogenesis cancer; underlying mechanism has not been fully understood yet. This study aims to investigate cancer specific T helper (Th)2 response inhibition colon (Cca) cell growth. results showed that with Cca (CT26 cell) extracts as an antigen, Cca-extract Th2 was induced Cca-bearing mice. mass size significantly reduced, or radically disappeared (5 out 10; 50%); survival rate markedly improved mice immunized...
The mammary gland undergoes fast cell proliferation during early pregnancy, yet the mechanism to ensure genome integrity this highly proliferative stage is largely unknown. We show that pregnancy triggers replicative stresses leading genetic instability in mice carrying a specific disruption of breast cancer associated gene-1 (BRCA1). was correlated with enhanced expression most genes encoding replisomes, which are positively regulated by estrogen/ERα signaling but negatively BRCA1. Our...
Abstract The pathogenesis of intestinal chronic inflammation is unclear. Food allergy plays an important role in the induction inflammation. This study aims to test a hypothesis that food initiates colitis. In this study, BALB/c mice were sensitized common allergen, ovalbumin (OVA) with cholera toxin (CT) as adjuvant. colon epithelial barrier function was assessed Ussing chamber technique. Expression T cell immunoglobulin mucin domain molecule-4 (TIM4) dendritic cells evaluated by flow...
The therapies for food allergy (FA) need to be improved. generation of inducible regulatory T cells (Tregs) can support immune tolerance in the body. This study aims suppress experimental FA by inducing Tregs through employment modified exosomes (mExosomes). In this study, mExosomes were prepared incubating dendritic with interleukin (IL)-2 and ovalbumin (OVA, used as a specific antigen) culture. Exosomes purified from culture supernatant mExosomes. A murine model was developed test effects...
Key Points Nasal secretions of allergic rhinitis patients were analyzed by Olink proteomics. Fifteen differentially expressed proteins (DEPs) identified. The DEPs significantly correlated with the total nasal symptom scores rhinitis.
Interleukin (IL)‐10–expressing B cells play a critical role in the immune homeostasis body; its regulation has not been fully understood. Micro‐RNA (miR)‐17‐92 cluster strong immunity. This study tests hypothesis that miR‐17‐92 suppresses IL‐10 expression cells. In this study, peripheral were collected from patients with allergic rhinitis (AR). The treated specific allergens, dust mite extracts, culture. expressions of and culture assessed by real‐time quantitative reverse transcription...